Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Henoch-Schonlein purpura (HSP) is a vasculitis of unknown aetiology, possibly involving immune complexes. The complement system is essential for the clearance of immune complexes. Our aim w...
Published in: | Scandinavian Journal of Immunology |
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Online Access: | http://hdl.handle.net/2336/2845 https://doi.org/10.1111/j.1365-3083.2005.01533.x |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/2845 2023-05-15T16:50:57+02:00 Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura Stefansson Thors, V Kolka, R Sigurdardottir, S L Edvardsson, V O Arason, G Haraldsson, A 2005-03-01 YES http://hdl.handle.net/2336/2845 https://doi.org/10.1111/j.1365-3083.2005.01533.x en eng Blackwell Scientific Publications http://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-3083.2005.01533.x Scand. J. Immunol. 2005, 61(3):274-8 0300-9475 15787745 doi:10.1111/j.1365-3083.2005.01533.x http://hdl.handle.net/2336/2845 Alleles Case-Control Studies Child Complement C4b Gene Frequency Immunoglobulin A Mannose-Binding Lectin Mutation Purpura Schoenlein-Henoch Article 2005 ftlandspitaliuni https://doi.org/10.1111/j.1365-3083.2005.01533.x 2022-05-29T08:20:50Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Henoch-Schonlein purpura (HSP) is a vasculitis of unknown aetiology, possibly involving immune complexes. The complement system is essential for the clearance of immune complexes. Our aim was to explore the hypothesis that patients with HSP have abnormal complements, contributing to the development of the disease. The study included 56 patients diagnosed with HSP at the Children's Hospital, Iceland between 1984 and 2000, and 98 blood donors as controls. Serum levels of immunoglobulin A, C4A, C4B and mannan-binding lectin were measured and compared between the two groups. C4 null alleles were significantly more common in HSP patients than in controls (P = 0.018) and were carried by 66.1% of the patients compared with 41.2% of the controls. This difference was due to an increased frequency of C4B*Q0 allele in the HSP group (0.25 versus 0.11 in the control group; P = 0.002). The fact that the majority of our patients carried a C4 null allele indicates that children with C4 deficiencies may have an increased risk of developing HSP. This may reflect inadequate complement activity and possibly present an opportunity to identify patients at risk of developing serious morbidity associated with HSP. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Scandinavian Journal of Immunology 61 3 274 278 |
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Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Alleles Case-Control Studies Child Complement C4b Gene Frequency Immunoglobulin A Mannose-Binding Lectin Mutation Purpura Schoenlein-Henoch |
spellingShingle |
Alleles Case-Control Studies Child Complement C4b Gene Frequency Immunoglobulin A Mannose-Binding Lectin Mutation Purpura Schoenlein-Henoch Stefansson Thors, V Kolka, R Sigurdardottir, S L Edvardsson, V O Arason, G Haraldsson, A Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura |
topic_facet |
Alleles Case-Control Studies Child Complement C4b Gene Frequency Immunoglobulin A Mannose-Binding Lectin Mutation Purpura Schoenlein-Henoch |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Henoch-Schonlein purpura (HSP) is a vasculitis of unknown aetiology, possibly involving immune complexes. The complement system is essential for the clearance of immune complexes. Our aim was to explore the hypothesis that patients with HSP have abnormal complements, contributing to the development of the disease. The study included 56 patients diagnosed with HSP at the Children's Hospital, Iceland between 1984 and 2000, and 98 blood donors as controls. Serum levels of immunoglobulin A, C4A, C4B and mannan-binding lectin were measured and compared between the two groups. C4 null alleles were significantly more common in HSP patients than in controls (P = 0.018) and were carried by 66.1% of the patients compared with 41.2% of the controls. This difference was due to an increased frequency of C4B*Q0 allele in the HSP group (0.25 versus 0.11 in the control group; P = 0.002). The fact that the majority of our patients carried a C4 null allele indicates that children with C4 deficiencies may have an increased risk of developing HSP. This may reflect inadequate complement activity and possibly present an opportunity to identify patients at risk of developing serious morbidity associated with HSP. |
format |
Article in Journal/Newspaper |
author |
Stefansson Thors, V Kolka, R Sigurdardottir, S L Edvardsson, V O Arason, G Haraldsson, A |
author_facet |
Stefansson Thors, V Kolka, R Sigurdardottir, S L Edvardsson, V O Arason, G Haraldsson, A |
author_sort |
Stefansson Thors, V |
title |
Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura |
title_short |
Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura |
title_full |
Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura |
title_fullStr |
Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura |
title_full_unstemmed |
Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura |
title_sort |
increased frequency of c4b*q0 alleles in patients with henoch-schönlein purpura |
publisher |
Blackwell Scientific Publications |
publishDate |
2005 |
url |
http://hdl.handle.net/2336/2845 https://doi.org/10.1111/j.1365-3083.2005.01533.x |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-3083.2005.01533.x Scand. J. Immunol. 2005, 61(3):274-8 0300-9475 15787745 doi:10.1111/j.1365-3083.2005.01533.x http://hdl.handle.net/2336/2845 |
op_doi |
https://doi.org/10.1111/j.1365-3083.2005.01533.x |
container_title |
Scandinavian Journal of Immunology |
container_volume |
61 |
container_issue |
3 |
container_start_page |
274 |
op_container_end_page |
278 |
_version_ |
1766041063698464768 |