Prevalence of chronic kidney disease based on estimated glomerular filtration rate and proteinuria in Icelandic adults
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: The purpose of this study was to compare three different equations to calculate estimated glomerular filtration rate (eGFR) based on serum creatinine (SCr) and to estimate the p...
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2005
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Online Access: | http://hdl.handle.net/2336/2805 https://doi.org/10.1093/ndt/gfh914 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/2805 2023-05-15T16:53:01+02:00 Prevalence of chronic kidney disease based on estimated glomerular filtration rate and proteinuria in Icelandic adults Viktorsdottir, Olof Palsson, Runolfur Andresdottir, Margret B Aspelund, Thor Gudnason, Vilmundur Indridason, Olafur S 2005-09-01 YES http://hdl.handle.net/2336/2805 https://doi.org/10.1093/ndt/gfh914 en eng Oxford University Press http://ndt.oxfordjournals.org/cgi/content/full/20/9/1799 Nephrol. Dial. Transplant. 2005, 20(9):1799-807 0931-0509 15928100 doi:10.1093/ndt/gfh914 NEP12 http://hdl.handle.net/2336/2805 Adult Age Distribution Aged 80 and over Body Height Body Weight Chronic Disease Creatinine/blood Female Glomerular Filtration Rate Humans Iceland/epidemiology Kidney Diseases Male Middle Aged Prevalence Proteinuria Sex Characteristics Article 2005 ftlandspitaliuni https://doi.org/10.1093/ndt/gfh914 2022-05-29T08:20:50Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: The purpose of this study was to compare three different equations to calculate estimated glomerular filtration rate (eGFR) based on serum creatinine (SCr) and to estimate the prevalence of chronic kidney disease (CKD) in the Icelandic population. METHODS: This was a cross-sectional study using data from the Reykjavik Heart Study. GFR was estimated with three equations: Equation I was based on 1/SCr; Equation II based on the Cockcroft-Gault equation; and Equation III was the modified MDRD equation. The eGFR calculated with Equation III and proteinuria were used to estimate the prevalence of CKD. The prevalence was age-standardized to the truncated world population. We used chi-square and ANCOVA to compare the group with low eGFR to age-matched controls. RESULTS: The subjects consisted of 9229 males and 10,027 females, aged 33-85 years. The equations performed very differently. Equation I showed women with higher eGFR than men and little change with age. Equation II showed men with higher eGFR than women and marked decline in eGFR with age. Equation III was similar to Equation II but the decline in eGFR with age was not as great. Regardless of the equation used, most subjects (63.7-80.7%) had an eGFR in the range of 60-89 ml/min/1.73 m2. Using Equation III, age-standardized prevalence of low eGFR for the population aged 35-80+ years was estimated to be 4.7 and 11.6% for men and women, respectively. The proportion of subjects with eGFR <60 ml/min/1.73 m2 increased with advancing age. An additional 2.39% of men and 0.89% of women had proteinuria. The prevalence of renal and cardiovascular risk factors including proteinuria, hypertension, lipid abnormalities and markers of inflammation was higher among those with low eGFR than age-matched controls. CONCLUSIONS: GFR estimates and the prevalence of CKD are dependent on the equation used to calculate eGFR. Unexpectedly, a low proportion of the ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Nephrology Dialysis Transplantation 20 9 1799 1807 |
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Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adult Age Distribution Aged 80 and over Body Height Body Weight Chronic Disease Creatinine/blood Female Glomerular Filtration Rate Humans Iceland/epidemiology Kidney Diseases Male Middle Aged Prevalence Proteinuria Sex Characteristics |
spellingShingle |
Adult Age Distribution Aged 80 and over Body Height Body Weight Chronic Disease Creatinine/blood Female Glomerular Filtration Rate Humans Iceland/epidemiology Kidney Diseases Male Middle Aged Prevalence Proteinuria Sex Characteristics Viktorsdottir, Olof Palsson, Runolfur Andresdottir, Margret B Aspelund, Thor Gudnason, Vilmundur Indridason, Olafur S Prevalence of chronic kidney disease based on estimated glomerular filtration rate and proteinuria in Icelandic adults |
topic_facet |
Adult Age Distribution Aged 80 and over Body Height Body Weight Chronic Disease Creatinine/blood Female Glomerular Filtration Rate Humans Iceland/epidemiology Kidney Diseases Male Middle Aged Prevalence Proteinuria Sex Characteristics |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: The purpose of this study was to compare three different equations to calculate estimated glomerular filtration rate (eGFR) based on serum creatinine (SCr) and to estimate the prevalence of chronic kidney disease (CKD) in the Icelandic population. METHODS: This was a cross-sectional study using data from the Reykjavik Heart Study. GFR was estimated with three equations: Equation I was based on 1/SCr; Equation II based on the Cockcroft-Gault equation; and Equation III was the modified MDRD equation. The eGFR calculated with Equation III and proteinuria were used to estimate the prevalence of CKD. The prevalence was age-standardized to the truncated world population. We used chi-square and ANCOVA to compare the group with low eGFR to age-matched controls. RESULTS: The subjects consisted of 9229 males and 10,027 females, aged 33-85 years. The equations performed very differently. Equation I showed women with higher eGFR than men and little change with age. Equation II showed men with higher eGFR than women and marked decline in eGFR with age. Equation III was similar to Equation II but the decline in eGFR with age was not as great. Regardless of the equation used, most subjects (63.7-80.7%) had an eGFR in the range of 60-89 ml/min/1.73 m2. Using Equation III, age-standardized prevalence of low eGFR for the population aged 35-80+ years was estimated to be 4.7 and 11.6% for men and women, respectively. The proportion of subjects with eGFR <60 ml/min/1.73 m2 increased with advancing age. An additional 2.39% of men and 0.89% of women had proteinuria. The prevalence of renal and cardiovascular risk factors including proteinuria, hypertension, lipid abnormalities and markers of inflammation was higher among those with low eGFR than age-matched controls. CONCLUSIONS: GFR estimates and the prevalence of CKD are dependent on the equation used to calculate eGFR. Unexpectedly, a low proportion of the ... |
format |
Article in Journal/Newspaper |
author |
Viktorsdottir, Olof Palsson, Runolfur Andresdottir, Margret B Aspelund, Thor Gudnason, Vilmundur Indridason, Olafur S |
author_facet |
Viktorsdottir, Olof Palsson, Runolfur Andresdottir, Margret B Aspelund, Thor Gudnason, Vilmundur Indridason, Olafur S |
author_sort |
Viktorsdottir, Olof |
title |
Prevalence of chronic kidney disease based on estimated glomerular filtration rate and proteinuria in Icelandic adults |
title_short |
Prevalence of chronic kidney disease based on estimated glomerular filtration rate and proteinuria in Icelandic adults |
title_full |
Prevalence of chronic kidney disease based on estimated glomerular filtration rate and proteinuria in Icelandic adults |
title_fullStr |
Prevalence of chronic kidney disease based on estimated glomerular filtration rate and proteinuria in Icelandic adults |
title_full_unstemmed |
Prevalence of chronic kidney disease based on estimated glomerular filtration rate and proteinuria in Icelandic adults |
title_sort |
prevalence of chronic kidney disease based on estimated glomerular filtration rate and proteinuria in icelandic adults |
publisher |
Oxford University Press |
publishDate |
2005 |
url |
http://hdl.handle.net/2336/2805 https://doi.org/10.1093/ndt/gfh914 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://ndt.oxfordjournals.org/cgi/content/full/20/9/1799 Nephrol. Dial. Transplant. 2005, 20(9):1799-807 0931-0509 15928100 doi:10.1093/ndt/gfh914 NEP12 http://hdl.handle.net/2336/2805 |
op_doi |
https://doi.org/10.1093/ndt/gfh914 |
container_title |
Nephrology Dialysis Transplantation |
container_volume |
20 |
container_issue |
9 |
container_start_page |
1799 |
op_container_end_page |
1807 |
_version_ |
1766043518153785344 |