Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study.
To access publisher full text version of this article. Please click on the hyperlink in Additional Link BACKGROUND: No population-based incidence studies of epilepsy have studied syndrome classification from the outset. We prospectively studied the incidence of a single unprovoked seizure and epilep...
Published in: | The Lancet Neurology |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Lancet Pub. Group
2005
|
Subjects: | |
Online Access: | http://hdl.handle.net/2336/2784 https://doi.org/10.1016/S1474-4422(05)70172-1 |
id |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/2784 |
---|---|
record_format |
openpolar |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/2784 2023-05-15T16:46:44+02:00 Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study. Olafsson, Elias Ludvigsson, Petur Gudmundsson, Gunnar Hesdorffer, Dale Kjartansson, Olafur Hauser, W Allen 2005-10-01 YES http://hdl.handle.net/2336/2784 https://doi.org/10.1016/S1474-4422(05)70172-1 en eng Lancet Pub. Group http://www.sciencedirect.com/science/article/B6X3F-4H27C5G-1/2/f9b2b7ec2da8830e855132683ecfb31a Lancet Neurol 2005, 4(10):627-34 1474-4422 16168931 doi:10.1016/S1474-4422(05)70172-1 http://hdl.handle.net/2336/2784 Adolescent Adult Age Distribution Aged Child Preschool Cohort Studies Epilepsy/*classification/diagnosis/*epidemiology Female Humans Iceland/epidemiology Incidence Infant Newborn Male Middle Aged Prospective Studies Risk Factors Sex Distribution Article 2005 ftlandspitaliuni https://doi.org/10.1016/S1474-4422(05)70172-1 2022-05-29T08:20:50Z To access publisher full text version of this article. Please click on the hyperlink in Additional Link BACKGROUND: No population-based incidence studies of epilepsy have studied syndrome classification from the outset. We prospectively studied the incidence of a single unprovoked seizure and epilepsy in the population of Iceland, and applied the syndrome classification endorsed by the International League Against Epilepsy to this population. METHODS: We used a nationwide surveillance system to prospectively identify all residents of Iceland who presented with a first diagnosis of a single unprovoked seizure or epilepsy between December 1995 and February 1999. All cases were classified by seizure type, cause or risk factors, and epilepsy syndrome. RESULTS: The mean annual incidence of first unprovoked seizures was 56.8 per 100,000 person-years, 23.5 per 100,000 person-years for single unprovoked seizures, and 33.3 per 100,000 person-years for epilepsy (recurrent unprovoked seizures). Incidence was similar in males and females. Partial seizures occurred in 40% and a putative cause was identified in 33%. Age-specific incidence was highest in the first year of life (130 per 100,000 person-years) and in those 65 years and older (110.5 per 100,000 person-years). Using strict diagnostic criteria for epilepsy syndromes, 58% of cases fell into non-informative categories. Idiopathic epilepsy syndromes were identified in 14% of all cases. INTERPRETATION: Findings are consistent with incidence studies from developed countries. Although the epilepsy syndrome classification might be useful in tertiary epilepsy centers, it has limited practicality in population studies and for use by general neurologists. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive The Lancet Neurology 4 10 627 634 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adolescent Adult Age Distribution Aged Child Preschool Cohort Studies Epilepsy/*classification/diagnosis/*epidemiology Female Humans Iceland/epidemiology Incidence Infant Newborn Male Middle Aged Prospective Studies Risk Factors Sex Distribution |
spellingShingle |
Adolescent Adult Age Distribution Aged Child Preschool Cohort Studies Epilepsy/*classification/diagnosis/*epidemiology Female Humans Iceland/epidemiology Incidence Infant Newborn Male Middle Aged Prospective Studies Risk Factors Sex Distribution Olafsson, Elias Ludvigsson, Petur Gudmundsson, Gunnar Hesdorffer, Dale Kjartansson, Olafur Hauser, W Allen Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study. |
topic_facet |
Adolescent Adult Age Distribution Aged Child Preschool Cohort Studies Epilepsy/*classification/diagnosis/*epidemiology Female Humans Iceland/epidemiology Incidence Infant Newborn Male Middle Aged Prospective Studies Risk Factors Sex Distribution |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Link BACKGROUND: No population-based incidence studies of epilepsy have studied syndrome classification from the outset. We prospectively studied the incidence of a single unprovoked seizure and epilepsy in the population of Iceland, and applied the syndrome classification endorsed by the International League Against Epilepsy to this population. METHODS: We used a nationwide surveillance system to prospectively identify all residents of Iceland who presented with a first diagnosis of a single unprovoked seizure or epilepsy between December 1995 and February 1999. All cases were classified by seizure type, cause or risk factors, and epilepsy syndrome. RESULTS: The mean annual incidence of first unprovoked seizures was 56.8 per 100,000 person-years, 23.5 per 100,000 person-years for single unprovoked seizures, and 33.3 per 100,000 person-years for epilepsy (recurrent unprovoked seizures). Incidence was similar in males and females. Partial seizures occurred in 40% and a putative cause was identified in 33%. Age-specific incidence was highest in the first year of life (130 per 100,000 person-years) and in those 65 years and older (110.5 per 100,000 person-years). Using strict diagnostic criteria for epilepsy syndromes, 58% of cases fell into non-informative categories. Idiopathic epilepsy syndromes were identified in 14% of all cases. INTERPRETATION: Findings are consistent with incidence studies from developed countries. Although the epilepsy syndrome classification might be useful in tertiary epilepsy centers, it has limited practicality in population studies and for use by general neurologists. |
format |
Article in Journal/Newspaper |
author |
Olafsson, Elias Ludvigsson, Petur Gudmundsson, Gunnar Hesdorffer, Dale Kjartansson, Olafur Hauser, W Allen |
author_facet |
Olafsson, Elias Ludvigsson, Petur Gudmundsson, Gunnar Hesdorffer, Dale Kjartansson, Olafur Hauser, W Allen |
author_sort |
Olafsson, Elias |
title |
Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study. |
title_short |
Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study. |
title_full |
Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study. |
title_fullStr |
Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study. |
title_full_unstemmed |
Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study. |
title_sort |
incidence of unprovoked seizures and epilepsy in iceland and assessment of the epilepsy syndrome classification: a prospective study. |
publisher |
Lancet Pub. Group |
publishDate |
2005 |
url |
http://hdl.handle.net/2336/2784 https://doi.org/10.1016/S1474-4422(05)70172-1 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.sciencedirect.com/science/article/B6X3F-4H27C5G-1/2/f9b2b7ec2da8830e855132683ecfb31a Lancet Neurol 2005, 4(10):627-34 1474-4422 16168931 doi:10.1016/S1474-4422(05)70172-1 http://hdl.handle.net/2336/2784 |
op_doi |
https://doi.org/10.1016/S1474-4422(05)70172-1 |
container_title |
The Lancet Neurology |
container_volume |
4 |
container_issue |
10 |
container_start_page |
627 |
op_container_end_page |
634 |
_version_ |
1766036832912408576 |