Serum osteoprotegerin and its relationship with bone mineral density and markers of bone turnover
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field INTRODUCTION: The purpose of this study was to compare age-related differences in osteoprotegerin (OPG) in relationship with BMD and the serum bone markers osteocalcin (OC), collagen crossl...
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/2771 2023-05-15T16:52:47+02:00 Serum osteoprotegerin and its relationship with bone mineral density and markers of bone turnover Indridason, Olafur S Franzson, Leifur Sigurdsson, Gunnar 2005-04-01 YES http://hdl.handle.net/2336/2771 https://doi.org/10.1007/s00198-004-1699-x en eng Springer International http://www.springerlink.com/content/rqa99jpc4najj1ry Osteoporos Int 2005, 16(4):417-23 0937-941X 15776220 doi:10.1007/s00198-004-1699-x http://hdl.handle.net/2336/2771 Osteoporosis international Adult Aged 80 and over Aging Biological Markers Bone Density Bone Remodeling Cross-Sectional Studies Female Glycoproteins Hip Joint Humans Lumbar Vertebrae Male Middle Aged Receptors Cytoplasmic and Nuclear Tumor Necrosis Factor Sex Characteristics Article 2005 ftlandspitaliuni https://doi.org/10.1007/s00198-004-1699-x 2022-05-29T08:20:50Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field INTRODUCTION: The purpose of this study was to compare age-related differences in osteoprotegerin (OPG) in relationship with BMD and the serum bone markers osteocalcin (OC), collagen crosslinks (CTX), and tartrate-resistant acid phosphatase 5b (TRACP-5b). METHODS: Data were derived from a cross-sectional study on bone health in a random sample of community-dwelling adults aged 30 to 85 years in the Reykjavik area in Iceland. All subjects had whole body, hip, and lumbar spine BMD measured (by DXA), gave blood samples, and answered a thorough questionnaire on medications and medical history. We assessed relationships using the Spearman correlation coefficient, partial correlation, and multivariable linear regression. Men and women were analyzed separately. RESULTS: Of 2,310 subjects invited over 2 years, 1,630 participated. After excluding individuals with diseases and medications affecting bone metabolism, 517 women (age 56.1 +/- 16.9 years) and 491 men (age 58.7 +/- 14.9 years) remained for analysis. OPG increased steadily with age in both genders without a gender difference. In women, BMD at all sites declined steadily after age 50. In men, BMD remained relatively stable until age 70, after which it declined significantly. After controlling for age, BMI, and other confounding variables, OPG showed only a borderline positive relationship with whole body BMD in men (P = 0.10), but the relationship was nonsignificant in women. In multivariable models, OPG was inversely related to TRACP-5b (P = 0.002) and positively with OC (P = 0.007), the OC/TRACP-5b (P = 0.001) and OC/CTX (P = 0.02) ratios in women. Among men, multivariable models showed a positive association between OPG and OC (P = 0.05) and OC/TRACP-5b (P < 0.009). CONCLUSIONS: We conclude that serum OPG levels are associated with a profile of bone turnover markers favoring bone formation, suggesting that OPG may be protective against ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Osteoporosis International 16 4 417 423 |
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Open Polar |
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Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adult Aged 80 and over Aging Biological Markers Bone Density Bone Remodeling Cross-Sectional Studies Female Glycoproteins Hip Joint Humans Lumbar Vertebrae Male Middle Aged Receptors Cytoplasmic and Nuclear Tumor Necrosis Factor Sex Characteristics |
spellingShingle |
Adult Aged 80 and over Aging Biological Markers Bone Density Bone Remodeling Cross-Sectional Studies Female Glycoproteins Hip Joint Humans Lumbar Vertebrae Male Middle Aged Receptors Cytoplasmic and Nuclear Tumor Necrosis Factor Sex Characteristics Indridason, Olafur S Franzson, Leifur Sigurdsson, Gunnar Serum osteoprotegerin and its relationship with bone mineral density and markers of bone turnover |
topic_facet |
Adult Aged 80 and over Aging Biological Markers Bone Density Bone Remodeling Cross-Sectional Studies Female Glycoproteins Hip Joint Humans Lumbar Vertebrae Male Middle Aged Receptors Cytoplasmic and Nuclear Tumor Necrosis Factor Sex Characteristics |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field INTRODUCTION: The purpose of this study was to compare age-related differences in osteoprotegerin (OPG) in relationship with BMD and the serum bone markers osteocalcin (OC), collagen crosslinks (CTX), and tartrate-resistant acid phosphatase 5b (TRACP-5b). METHODS: Data were derived from a cross-sectional study on bone health in a random sample of community-dwelling adults aged 30 to 85 years in the Reykjavik area in Iceland. All subjects had whole body, hip, and lumbar spine BMD measured (by DXA), gave blood samples, and answered a thorough questionnaire on medications and medical history. We assessed relationships using the Spearman correlation coefficient, partial correlation, and multivariable linear regression. Men and women were analyzed separately. RESULTS: Of 2,310 subjects invited over 2 years, 1,630 participated. After excluding individuals with diseases and medications affecting bone metabolism, 517 women (age 56.1 +/- 16.9 years) and 491 men (age 58.7 +/- 14.9 years) remained for analysis. OPG increased steadily with age in both genders without a gender difference. In women, BMD at all sites declined steadily after age 50. In men, BMD remained relatively stable until age 70, after which it declined significantly. After controlling for age, BMI, and other confounding variables, OPG showed only a borderline positive relationship with whole body BMD in men (P = 0.10), but the relationship was nonsignificant in women. In multivariable models, OPG was inversely related to TRACP-5b (P = 0.002) and positively with OC (P = 0.007), the OC/TRACP-5b (P = 0.001) and OC/CTX (P = 0.02) ratios in women. Among men, multivariable models showed a positive association between OPG and OC (P = 0.05) and OC/TRACP-5b (P < 0.009). CONCLUSIONS: We conclude that serum OPG levels are associated with a profile of bone turnover markers favoring bone formation, suggesting that OPG may be protective against ... |
format |
Article in Journal/Newspaper |
author |
Indridason, Olafur S Franzson, Leifur Sigurdsson, Gunnar |
author_facet |
Indridason, Olafur S Franzson, Leifur Sigurdsson, Gunnar |
author_sort |
Indridason, Olafur S |
title |
Serum osteoprotegerin and its relationship with bone mineral density and markers of bone turnover |
title_short |
Serum osteoprotegerin and its relationship with bone mineral density and markers of bone turnover |
title_full |
Serum osteoprotegerin and its relationship with bone mineral density and markers of bone turnover |
title_fullStr |
Serum osteoprotegerin and its relationship with bone mineral density and markers of bone turnover |
title_full_unstemmed |
Serum osteoprotegerin and its relationship with bone mineral density and markers of bone turnover |
title_sort |
serum osteoprotegerin and its relationship with bone mineral density and markers of bone turnover |
publisher |
Springer International |
publishDate |
2005 |
url |
http://hdl.handle.net/2336/2771 https://doi.org/10.1007/s00198-004-1699-x |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.springerlink.com/content/rqa99jpc4najj1ry Osteoporos Int 2005, 16(4):417-23 0937-941X 15776220 doi:10.1007/s00198-004-1699-x http://hdl.handle.net/2336/2771 Osteoporosis international |
op_doi |
https://doi.org/10.1007/s00198-004-1699-x |
container_title |
Osteoporosis International |
container_volume |
16 |
container_issue |
4 |
container_start_page |
417 |
op_container_end_page |
423 |
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1766043161071714304 |