The association between glucose abnormalities and heart failure in the population-based Reykjavik study
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field OBJECTIVE: Diabetes is an independent risk factor for heart failure, whereas the relation between heart failure and abnormal glucose regulation (AGR) needs further evaluation. We studied thi...
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American Diabetes Association
2005
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Online Access: | http://hdl.handle.net/2336/2706 https://doi.org/10.2337/diacare.28.3.612 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/2706 2023-05-15T16:51:49+02:00 The association between glucose abnormalities and heart failure in the population-based Reykjavik study Thrainsdottir, Inga S Aspelund, Thor Thorgeirsson, Gudmundur Gudnason, Vilmundur Hardarson, Thordur Malmberg, Klas Sigurdsson, Gunnar Rydén, Lars 2005-03-01 YES http://hdl.handle.net/2336/2706 https://doi.org/10.2337/diacare.28.3.612 en eng American Diabetes Association http://care.diabetesjournals.org/cgi/content/abstract/28/3/612 Diabetes Care 2005, 28(3):612-6 0149-5992 15735197 doi:10.2337/diacare.28.3.612 CAR12 http://hdl.handle.net/2336/2706 Diabetes care Adult Aged Blood Glucose Diabetes Mellitus Type 2 Female Humans Iceland/epidemiology Male Middle Aged Prevalence Reference Values Heart Failure Congestive Diabetic Angiopathies Article 2005 ftlandspitaliuni https://doi.org/10.2337/diacare.28.3.612 2022-05-29T08:20:50Z To access publisher full text version of this article. Please click on the hyperlink in Additional Link field OBJECTIVE: Diabetes is an independent risk factor for heart failure, whereas the relation between heart failure and abnormal glucose regulation (AGR) needs further evaluation. We studied this combination in the Reykjavik Study. RESEARCH DESIGN AND METHODS: The Reykjavik Study, a population-based cohort study during 1967-1997, recruited 19,381 participants aged 33-84 years who were followed until 2002. Oral glucose tolerance tests and chest X-rays were obtained from all participants. Cases were defined in accordance with World Health Organization criteria for type 2 diabetes or AGR (impaired glucose tolerance or impaired fasting glucose) and European Society of Cardiology guidelines for heart failure. RESULTS: The overall prevalence of type 2 diabetes and heart failure was 0.5% in men and 0.4% in women, while AGR and heart failure were found in 0.7% of men and 0.6% of women. Among participants with normal glucose regulation, heart failure was diagnosed in 3.2% compared with 6.0 and 11.8% among those with AGR and type 2 diabetes, respectively. The prevalence of type 2 diabetes in the age-group 45-65 years increased in both sexes during the period (P for trend = 0.007). The odds ratio was 2.8 (95% CI 2.2-3.6) for the association between type 2 diabetes and heart failure and 1.7 (1.4-2.1) between AGR and heart failure. CONCLUSIONS: There is a strong association between any form of glucometabolic perturbation and heart failure. Future studies in this field should focus on all types of glucose abnormalities rather than previously diagnosed diabetes only. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Diabetes Care 28 3 612 616 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adult Aged Blood Glucose Diabetes Mellitus Type 2 Female Humans Iceland/epidemiology Male Middle Aged Prevalence Reference Values Heart Failure Congestive Diabetic Angiopathies |
spellingShingle |
Adult Aged Blood Glucose Diabetes Mellitus Type 2 Female Humans Iceland/epidemiology Male Middle Aged Prevalence Reference Values Heart Failure Congestive Diabetic Angiopathies Thrainsdottir, Inga S Aspelund, Thor Thorgeirsson, Gudmundur Gudnason, Vilmundur Hardarson, Thordur Malmberg, Klas Sigurdsson, Gunnar Rydén, Lars The association between glucose abnormalities and heart failure in the population-based Reykjavik study |
topic_facet |
Adult Aged Blood Glucose Diabetes Mellitus Type 2 Female Humans Iceland/epidemiology Male Middle Aged Prevalence Reference Values Heart Failure Congestive Diabetic Angiopathies |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field OBJECTIVE: Diabetes is an independent risk factor for heart failure, whereas the relation between heart failure and abnormal glucose regulation (AGR) needs further evaluation. We studied this combination in the Reykjavik Study. RESEARCH DESIGN AND METHODS: The Reykjavik Study, a population-based cohort study during 1967-1997, recruited 19,381 participants aged 33-84 years who were followed until 2002. Oral glucose tolerance tests and chest X-rays were obtained from all participants. Cases were defined in accordance with World Health Organization criteria for type 2 diabetes or AGR (impaired glucose tolerance or impaired fasting glucose) and European Society of Cardiology guidelines for heart failure. RESULTS: The overall prevalence of type 2 diabetes and heart failure was 0.5% in men and 0.4% in women, while AGR and heart failure were found in 0.7% of men and 0.6% of women. Among participants with normal glucose regulation, heart failure was diagnosed in 3.2% compared with 6.0 and 11.8% among those with AGR and type 2 diabetes, respectively. The prevalence of type 2 diabetes in the age-group 45-65 years increased in both sexes during the period (P for trend = 0.007). The odds ratio was 2.8 (95% CI 2.2-3.6) for the association between type 2 diabetes and heart failure and 1.7 (1.4-2.1) between AGR and heart failure. CONCLUSIONS: There is a strong association between any form of glucometabolic perturbation and heart failure. Future studies in this field should focus on all types of glucose abnormalities rather than previously diagnosed diabetes only. |
format |
Article in Journal/Newspaper |
author |
Thrainsdottir, Inga S Aspelund, Thor Thorgeirsson, Gudmundur Gudnason, Vilmundur Hardarson, Thordur Malmberg, Klas Sigurdsson, Gunnar Rydén, Lars |
author_facet |
Thrainsdottir, Inga S Aspelund, Thor Thorgeirsson, Gudmundur Gudnason, Vilmundur Hardarson, Thordur Malmberg, Klas Sigurdsson, Gunnar Rydén, Lars |
author_sort |
Thrainsdottir, Inga S |
title |
The association between glucose abnormalities and heart failure in the population-based Reykjavik study |
title_short |
The association between glucose abnormalities and heart failure in the population-based Reykjavik study |
title_full |
The association between glucose abnormalities and heart failure in the population-based Reykjavik study |
title_fullStr |
The association between glucose abnormalities and heart failure in the population-based Reykjavik study |
title_full_unstemmed |
The association between glucose abnormalities and heart failure in the population-based Reykjavik study |
title_sort |
association between glucose abnormalities and heart failure in the population-based reykjavik study |
publisher |
American Diabetes Association |
publishDate |
2005 |
url |
http://hdl.handle.net/2336/2706 https://doi.org/10.2337/diacare.28.3.612 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://care.diabetesjournals.org/cgi/content/abstract/28/3/612 Diabetes Care 2005, 28(3):612-6 0149-5992 15735197 doi:10.2337/diacare.28.3.612 CAR12 http://hdl.handle.net/2336/2706 Diabetes care |
op_doi |
https://doi.org/10.2337/diacare.28.3.612 |
container_title |
Diabetes Care |
container_volume |
28 |
container_issue |
3 |
container_start_page |
612 |
op_container_end_page |
616 |
_version_ |
1766041905456480256 |