Effect of incidental detection for survival of patients with renal cell carcinoma: results of population-based study of 701 patients
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVES: To conduct a population-based study to evaluate the effect of incidental detection of renal cell carcinoma (RCC) on survival. Incidental detection of RCC has increased significa...
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Online Access: | http://hdl.handle.net/2336/2684 https://doi.org/10.1016/j.urology.2005.07.009 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/2684 2023-05-15T16:49:08+02:00 Effect of incidental detection for survival of patients with renal cell carcinoma: results of population-based study of 701 patients Gudbjartsson, Tomas Thoroddsen, Asgeir Petursdottir, Vigdis Hardarson, Sverrir Magnusson, Jonas Einarsson, Gudmundur V 2005-12-01 YES http://hdl.handle.net/2336/2684 https://doi.org/10.1016/j.urology.2005.07.009 en eng Elsevier Science http://www.sciencedirect.com/science/article/B6VJW-4HTK6CX-C/1/ab52d7a0ee1b7d63147abbbe3c5be567 Urology 2005, 66(6):1186-91 1527-9995 16360438 doi:10.1016/j.urology.2005.07.009 SAG12 URO12 http://hdl.handle.net/2336/2684 Urology Carcinoma Renal Cell Kidney Neoplasms Female Male Humans Middle Aged Aged Incidental Findings Prognosis Retrospective Studies Survival Rate Article 2005 ftlandspitaliuni https://doi.org/10.1016/j.urology.2005.07.009 2022-05-29T08:20:50Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVES: To conduct a population-based study to evaluate the effect of incidental detection of renal cell carcinoma (RCC) on survival. Incidental detection of RCC has increased significantly in recent years because of widespread use of abdominal imaging. The patients with incidentally diagnosed RCC have better survival; however, because of possible "lead time" bias and stage migration, the real implications of incidental detection on survival have been a matter of debate. METHODS: All living patients diagnosed with RCC in Iceland between 1971 and 2000 were included (n = 701). The histologic findings were verified, the stage (extent) of the disease was determined, and the incidence, mortality, and survival were evaluated. RESULTS: The strongest predictors of mortality were stage and nuclear grade. After correcting for these factors in the multivariate analysis, incidental diagnosis, histologic subtype, and gender lost their significance as independent prognostic factors of death. However, the incidentally diagnosed tumors were 2.3 cm smaller on average and at a lower stage and grade than symptomatic tumors, with significantly better patient survival than those with symptomatic tumors on univariate analysis (76% versus 44% 5-year disease-specific survival). An increased incidence of RCC was only seen in men, but incidental detection increased threefold during the study period in both sexes, with significant improvement in survival for the whole group as a result. CONCLUSIONS: The increased frequency of incidental detection has improved the survival of patients with RCC in Iceland. Incidental detection was not an independent prognostic factor of death, indicating that these tumors are of a similar biologic nature as symptomatic RCCs, only diagnosed earlier. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Urology 66 6 1186 1191 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Carcinoma Renal Cell Kidney Neoplasms Female Male Humans Middle Aged Aged Incidental Findings Prognosis Retrospective Studies Survival Rate |
spellingShingle |
Carcinoma Renal Cell Kidney Neoplasms Female Male Humans Middle Aged Aged Incidental Findings Prognosis Retrospective Studies Survival Rate Gudbjartsson, Tomas Thoroddsen, Asgeir Petursdottir, Vigdis Hardarson, Sverrir Magnusson, Jonas Einarsson, Gudmundur V Effect of incidental detection for survival of patients with renal cell carcinoma: results of population-based study of 701 patients |
topic_facet |
Carcinoma Renal Cell Kidney Neoplasms Female Male Humans Middle Aged Aged Incidental Findings Prognosis Retrospective Studies Survival Rate |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVES: To conduct a population-based study to evaluate the effect of incidental detection of renal cell carcinoma (RCC) on survival. Incidental detection of RCC has increased significantly in recent years because of widespread use of abdominal imaging. The patients with incidentally diagnosed RCC have better survival; however, because of possible "lead time" bias and stage migration, the real implications of incidental detection on survival have been a matter of debate. METHODS: All living patients diagnosed with RCC in Iceland between 1971 and 2000 were included (n = 701). The histologic findings were verified, the stage (extent) of the disease was determined, and the incidence, mortality, and survival were evaluated. RESULTS: The strongest predictors of mortality were stage and nuclear grade. After correcting for these factors in the multivariate analysis, incidental diagnosis, histologic subtype, and gender lost their significance as independent prognostic factors of death. However, the incidentally diagnosed tumors were 2.3 cm smaller on average and at a lower stage and grade than symptomatic tumors, with significantly better patient survival than those with symptomatic tumors on univariate analysis (76% versus 44% 5-year disease-specific survival). An increased incidence of RCC was only seen in men, but incidental detection increased threefold during the study period in both sexes, with significant improvement in survival for the whole group as a result. CONCLUSIONS: The increased frequency of incidental detection has improved the survival of patients with RCC in Iceland. Incidental detection was not an independent prognostic factor of death, indicating that these tumors are of a similar biologic nature as symptomatic RCCs, only diagnosed earlier. |
format |
Article in Journal/Newspaper |
author |
Gudbjartsson, Tomas Thoroddsen, Asgeir Petursdottir, Vigdis Hardarson, Sverrir Magnusson, Jonas Einarsson, Gudmundur V |
author_facet |
Gudbjartsson, Tomas Thoroddsen, Asgeir Petursdottir, Vigdis Hardarson, Sverrir Magnusson, Jonas Einarsson, Gudmundur V |
author_sort |
Gudbjartsson, Tomas |
title |
Effect of incidental detection for survival of patients with renal cell carcinoma: results of population-based study of 701 patients |
title_short |
Effect of incidental detection for survival of patients with renal cell carcinoma: results of population-based study of 701 patients |
title_full |
Effect of incidental detection for survival of patients with renal cell carcinoma: results of population-based study of 701 patients |
title_fullStr |
Effect of incidental detection for survival of patients with renal cell carcinoma: results of population-based study of 701 patients |
title_full_unstemmed |
Effect of incidental detection for survival of patients with renal cell carcinoma: results of population-based study of 701 patients |
title_sort |
effect of incidental detection for survival of patients with renal cell carcinoma: results of population-based study of 701 patients |
publisher |
Elsevier Science |
publishDate |
2005 |
url |
http://hdl.handle.net/2336/2684 https://doi.org/10.1016/j.urology.2005.07.009 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.sciencedirect.com/science/article/B6VJW-4HTK6CX-C/1/ab52d7a0ee1b7d63147abbbe3c5be567 Urology 2005, 66(6):1186-91 1527-9995 16360438 doi:10.1016/j.urology.2005.07.009 SAG12 URO12 http://hdl.handle.net/2336/2684 Urology |
op_doi |
https://doi.org/10.1016/j.urology.2005.07.009 |
container_title |
Urology |
container_volume |
66 |
container_issue |
6 |
container_start_page |
1186 |
op_container_end_page |
1191 |
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1766039197124132864 |