Renal oncocytoma: a clinicopathological analysis of 45 consecutive cases
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To evaluate the clinical behaviour and pathology of renal oncocytoma in a well-defined population over a 30-year period. PATIENTS AND METHODS: In a retrospective population-based...
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2005
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/2680 2023-05-15T16:49:39+02:00 Renal oncocytoma: a clinicopathological analysis of 45 consecutive cases Gudbjartsson, Tomas Hardarson, Sverrir Petursdottir, Vigdis Thoroddsen, Asgeir Magnusson, Jonas Einarsson, Gudmundur V 2005-12-01 YES http://hdl.handle.net/2336/2680 https://doi.org/10.1111/j.1464-410X.2005.05827.x en eng Blackwell Science http://onlinelibrary.wiley.com/doi/abs/10.1111/j.1464-410X.2005.05827.x BJU Int 2005, 96(9):1275-9 1464-4096 16287444 doi:10.1111/j.1464-410X.2005.05827.x URO12 SAG12 TAS12 http://hdl.handle.net/2336/2680 Adenoma Oxyphilic Kidney Neoplasms Neoplasm Staging Adult Aged 80 and over Female Male Middle Aged Follow-Up Studies Research Support Non-U.S. Gov't Retrospective Studies Statistics Nonparametric Survival Analysis Article 2005 ftlandspitaliuni https://doi.org/10.1111/j.1464-410X.2005.05827.x 2022-05-29T08:20:50Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To evaluate the clinical behaviour and pathology of renal oncocytoma in a well-defined population over a 30-year period. PATIENTS AND METHODS: In a retrospective population-based study we assessed relevant clinical and pathological factors in 45 patients (31 men and 14 women) diagnosed with renal oncocytoma in Iceland between 1971 and 2000. Clinical presentation, pathology, survival and causes of death were evaluated. RESULTS: The age-standardized incidence was 0.3 per 100,000 per year for both men and women, the incidence of oncocytomas being 5.5% of renal cell carcinomas (RCCs) diagnosed during the same period in Iceland. Fourteen patients were diagnosed at autopsy for an unrelated disease. Of 31 living patients (mean age 70.5 years), seven were diagnosed incidentally (23%), and the others had presented with haematuria (32%), abdominal pain (29%), and weight loss (10%). All the patients had a radical nephrectomy, except for one with bilateral oncocytoma who had a partial nephrectomy. The mean (range) tumour size was 5.7 (0.9-12) cm. Eighteen patients (58%) were diagnosed at Tumour-Node-Metastasis stage I, 10 at stage II (32%) and three at stage III (10%), all of those at stage III having renal capsular penetration or tumour invasion into perirenal fat tissue (T3aN0M0). No patients were diagnosed with lymph node or distant metastasis. Two cases of coexisting RCC were detected. After a median follow-up of 8.3 years there were no recurrences or deaths from oncocytoma (100% disease-specific survival). The overall 5-year survival was 63%, with most patients dying from cardiovascular diseases or nonrenal cancers. CONCLUSIONS: In most cases renal oncocytoma behaves like a benign tumour; the long-term prognosis is excellent. Thus, in the present patients, radical nephrectomy could be regarded as an over-treatment and nephron-sparing surgery as more appropriate, especially in patients with small ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive BJU International 96 9 1275 1279 |
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Hirsla - Landspítali University Hospital research archive |
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ftlandspitaliuni |
language |
English |
topic |
Adenoma Oxyphilic Kidney Neoplasms Neoplasm Staging Adult Aged 80 and over Female Male Middle Aged Follow-Up Studies Research Support Non-U.S. Gov't Retrospective Studies Statistics Nonparametric Survival Analysis |
spellingShingle |
Adenoma Oxyphilic Kidney Neoplasms Neoplasm Staging Adult Aged 80 and over Female Male Middle Aged Follow-Up Studies Research Support Non-U.S. Gov't Retrospective Studies Statistics Nonparametric Survival Analysis Gudbjartsson, Tomas Hardarson, Sverrir Petursdottir, Vigdis Thoroddsen, Asgeir Magnusson, Jonas Einarsson, Gudmundur V Renal oncocytoma: a clinicopathological analysis of 45 consecutive cases |
topic_facet |
Adenoma Oxyphilic Kidney Neoplasms Neoplasm Staging Adult Aged 80 and over Female Male Middle Aged Follow-Up Studies Research Support Non-U.S. Gov't Retrospective Studies Statistics Nonparametric Survival Analysis |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To evaluate the clinical behaviour and pathology of renal oncocytoma in a well-defined population over a 30-year period. PATIENTS AND METHODS: In a retrospective population-based study we assessed relevant clinical and pathological factors in 45 patients (31 men and 14 women) diagnosed with renal oncocytoma in Iceland between 1971 and 2000. Clinical presentation, pathology, survival and causes of death were evaluated. RESULTS: The age-standardized incidence was 0.3 per 100,000 per year for both men and women, the incidence of oncocytomas being 5.5% of renal cell carcinomas (RCCs) diagnosed during the same period in Iceland. Fourteen patients were diagnosed at autopsy for an unrelated disease. Of 31 living patients (mean age 70.5 years), seven were diagnosed incidentally (23%), and the others had presented with haematuria (32%), abdominal pain (29%), and weight loss (10%). All the patients had a radical nephrectomy, except for one with bilateral oncocytoma who had a partial nephrectomy. The mean (range) tumour size was 5.7 (0.9-12) cm. Eighteen patients (58%) were diagnosed at Tumour-Node-Metastasis stage I, 10 at stage II (32%) and three at stage III (10%), all of those at stage III having renal capsular penetration or tumour invasion into perirenal fat tissue (T3aN0M0). No patients were diagnosed with lymph node or distant metastasis. Two cases of coexisting RCC were detected. After a median follow-up of 8.3 years there were no recurrences or deaths from oncocytoma (100% disease-specific survival). The overall 5-year survival was 63%, with most patients dying from cardiovascular diseases or nonrenal cancers. CONCLUSIONS: In most cases renal oncocytoma behaves like a benign tumour; the long-term prognosis is excellent. Thus, in the present patients, radical nephrectomy could be regarded as an over-treatment and nephron-sparing surgery as more appropriate, especially in patients with small ... |
format |
Article in Journal/Newspaper |
author |
Gudbjartsson, Tomas Hardarson, Sverrir Petursdottir, Vigdis Thoroddsen, Asgeir Magnusson, Jonas Einarsson, Gudmundur V |
author_facet |
Gudbjartsson, Tomas Hardarson, Sverrir Petursdottir, Vigdis Thoroddsen, Asgeir Magnusson, Jonas Einarsson, Gudmundur V |
author_sort |
Gudbjartsson, Tomas |
title |
Renal oncocytoma: a clinicopathological analysis of 45 consecutive cases |
title_short |
Renal oncocytoma: a clinicopathological analysis of 45 consecutive cases |
title_full |
Renal oncocytoma: a clinicopathological analysis of 45 consecutive cases |
title_fullStr |
Renal oncocytoma: a clinicopathological analysis of 45 consecutive cases |
title_full_unstemmed |
Renal oncocytoma: a clinicopathological analysis of 45 consecutive cases |
title_sort |
renal oncocytoma: a clinicopathological analysis of 45 consecutive cases |
publisher |
Blackwell Science |
publishDate |
2005 |
url |
http://hdl.handle.net/2336/2680 https://doi.org/10.1111/j.1464-410X.2005.05827.x |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://onlinelibrary.wiley.com/doi/abs/10.1111/j.1464-410X.2005.05827.x BJU Int 2005, 96(9):1275-9 1464-4096 16287444 doi:10.1111/j.1464-410X.2005.05827.x URO12 SAG12 TAS12 http://hdl.handle.net/2336/2680 |
op_doi |
https://doi.org/10.1111/j.1464-410X.2005.05827.x |
container_title |
BJU International |
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96 |
container_issue |
9 |
container_start_page |
1275 |
op_container_end_page |
1279 |
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1766039787828936704 |