The adjuvant LT-K63 can restore delayed maturation of follicular dendritic cells and poor persistence of both protein- and polysaccharide-specific antibody-secreting cells in neonatal mice.

• Published in: The Journal of Immunology
• Main Authors: Bjarnarson, Stefania P, Adarna, Brenda C, Benonisson, Hreinn, Del Giudice, Giuseppe, Jonsdottir, Ingileif
• Other Authors: Department of Immunology, Landspitali, The National University Hospital of Iceland, Hringbraut, 101 Reykjavik, Iceland.
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2012
• Subjects: Adjuvants; Immunologic; Animals; Newborn; Antibodies; Bacterial; Antibody-Producing Cells; Bacterial Toxins; Cell Differentiation; CpG Islands; Dendritic Cells; Follicular; Enterotoxins; Escherichia coli Proteins; Mice; Inbred Strains; Oligodeoxyribonucleotides; Polysaccharides; Tetanus Toxoid; Moma; Iceland
• Online Access: http://hdl.handle.net/2336/249333; https://doi.org/10.4049/jimmunol.1200761

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Ab responses in early life are low and short-lived; therefore, induction of protective immunity requires repeated vaccinations. One of the major limitations in early-life immunity is delay...