Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Exacerbation of chronic psoriasis can be associated with streptococcal throat infections, and T cells that respond to peptide sequences common to streptococcal M proteins and skin keratins...
Published in: | The Journal of Immunology |
---|---|
Main Authors: | , , , , , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
American Association of Immunologists
2012
|
Subjects: | |
Online Access: | http://hdl.handle.net/2336/239051 https://doi.org/10.4049/jimmunol.1102834 |
id |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/239051 |
---|---|
record_format |
openpolar |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/239051 2023-05-15T16:48:44+02:00 Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants. Thorleifsdottir, Ragna Hlin Sigurdardottir, Sigrun Laufey Sigurgeirsson, Bardur Olafsson, Jon Hjaltalin Sigurdsson, Martin Ingi Petersen, Hannes Arnadottir, Sigurlaug Gudjonsson, Johann Eli Johnston, Andrew Valdimarsson, Helgi Department of Immunology, Landspitali University Hospital, 101 Reykjavik, Iceland. 2012-08-17 http://hdl.handle.net/2336/239051 https://doi.org/10.4049/jimmunol.1102834 en eng American Association of Immunologists http://dx.doi.org/10.4049/jimmunol.1102834 J. Immunol. 2012, 188(10):5160-5 1550-6606 22491250 doi:10.4049/jimmunol.1102834 http://hdl.handle.net/2336/239051 Journal of immunology (Baltimore, Md. : 1950) Archived with thanks to Journal of immunology (Baltimore, Md. : 1950) Landspitali Access - LSH-aðgangur Adolescent Adult Antigens Bacterial Bacterial Outer Membrane Proteins Carrier Proteins Cell Movement Child Preschool Chronic Disease Epitopes T-Lymphocyte Female Humans Keratins Lymphopenia Male Middle Aged Palatine Tonsil Prospective Studies Psoriasis Skin T-Lymphocyte Subsets Tonsillectomy Young Adult Article Ónæmisfræði, HNE, Húð- og kyn 2012 ftlandspitaliuni https://doi.org/10.4049/jimmunol.1102834 2022-05-29T08:21:49Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Exacerbation of chronic psoriasis can be associated with streptococcal throat infections, and T cells that respond to peptide sequences common to streptococcal M proteins and skin keratins have been detected in patients' blood. To our knowledge, we have conducted the first blinded, prospective study to assess the impact of tonsillectomy on psoriasis. Twenty-nine patients with chronic psoriasis and history of exacerbation after sore throat were randomly assigned to tonsillectomy (n = 15) or control (n = 14) groups and monitored for 2 y clinically and by enumeration of circulating skin homing T cells that respond to short homologous M protein or keratin peptides. Thirteen patients (86%) showed sustained improvement after tonsillectomy ranging from 30 to 90% reduction in disease severity. Furthermore, there was a close correlation between the degree of clinical improvement in individual patients and reduction in the frequency of peptide-reactive skin-homing T cells in their circulation. No corresponding clinical or immunologic changes were observed among the controls. These findings indicate that tonsillectomy may have a beneficial effect on chronic psoriasis because the palatine tonsils generate effector T cells that recognize keratin determinants in the skin. Icelandic Research Fund, Icelandic Research Fund for Graduate Students, University of Iceland, National University Hospital in Iceland Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive The Journal of Immunology 188 10 5160 5165 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adolescent Adult Antigens Bacterial Bacterial Outer Membrane Proteins Carrier Proteins Cell Movement Child Preschool Chronic Disease Epitopes T-Lymphocyte Female Humans Keratins Lymphopenia Male Middle Aged Palatine Tonsil Prospective Studies Psoriasis Skin T-Lymphocyte Subsets Tonsillectomy Young Adult |
spellingShingle |
Adolescent Adult Antigens Bacterial Bacterial Outer Membrane Proteins Carrier Proteins Cell Movement Child Preschool Chronic Disease Epitopes T-Lymphocyte Female Humans Keratins Lymphopenia Male Middle Aged Palatine Tonsil Prospective Studies Psoriasis Skin T-Lymphocyte Subsets Tonsillectomy Young Adult Thorleifsdottir, Ragna Hlin Sigurdardottir, Sigrun Laufey Sigurgeirsson, Bardur Olafsson, Jon Hjaltalin Sigurdsson, Martin Ingi Petersen, Hannes Arnadottir, Sigurlaug Gudjonsson, Johann Eli Johnston, Andrew Valdimarsson, Helgi Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants. |
topic_facet |
Adolescent Adult Antigens Bacterial Bacterial Outer Membrane Proteins Carrier Proteins Cell Movement Child Preschool Chronic Disease Epitopes T-Lymphocyte Female Humans Keratins Lymphopenia Male Middle Aged Palatine Tonsil Prospective Studies Psoriasis Skin T-Lymphocyte Subsets Tonsillectomy Young Adult |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Exacerbation of chronic psoriasis can be associated with streptococcal throat infections, and T cells that respond to peptide sequences common to streptococcal M proteins and skin keratins have been detected in patients' blood. To our knowledge, we have conducted the first blinded, prospective study to assess the impact of tonsillectomy on psoriasis. Twenty-nine patients with chronic psoriasis and history of exacerbation after sore throat were randomly assigned to tonsillectomy (n = 15) or control (n = 14) groups and monitored for 2 y clinically and by enumeration of circulating skin homing T cells that respond to short homologous M protein or keratin peptides. Thirteen patients (86%) showed sustained improvement after tonsillectomy ranging from 30 to 90% reduction in disease severity. Furthermore, there was a close correlation between the degree of clinical improvement in individual patients and reduction in the frequency of peptide-reactive skin-homing T cells in their circulation. No corresponding clinical or immunologic changes were observed among the controls. These findings indicate that tonsillectomy may have a beneficial effect on chronic psoriasis because the palatine tonsils generate effector T cells that recognize keratin determinants in the skin. Icelandic Research Fund, Icelandic Research Fund for Graduate Students, University of Iceland, National University Hospital in Iceland |
author2 |
Department of Immunology, Landspitali University Hospital, 101 Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Thorleifsdottir, Ragna Hlin Sigurdardottir, Sigrun Laufey Sigurgeirsson, Bardur Olafsson, Jon Hjaltalin Sigurdsson, Martin Ingi Petersen, Hannes Arnadottir, Sigurlaug Gudjonsson, Johann Eli Johnston, Andrew Valdimarsson, Helgi |
author_facet |
Thorleifsdottir, Ragna Hlin Sigurdardottir, Sigrun Laufey Sigurgeirsson, Bardur Olafsson, Jon Hjaltalin Sigurdsson, Martin Ingi Petersen, Hannes Arnadottir, Sigurlaug Gudjonsson, Johann Eli Johnston, Andrew Valdimarsson, Helgi |
author_sort |
Thorleifsdottir, Ragna Hlin |
title |
Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants. |
title_short |
Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants. |
title_full |
Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants. |
title_fullStr |
Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants. |
title_full_unstemmed |
Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants. |
title_sort |
improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating t cells that recognize streptococcal determinants and homologous skin determinants. |
publisher |
American Association of Immunologists |
publishDate |
2012 |
url |
http://hdl.handle.net/2336/239051 https://doi.org/10.4049/jimmunol.1102834 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.4049/jimmunol.1102834 J. Immunol. 2012, 188(10):5160-5 1550-6606 22491250 doi:10.4049/jimmunol.1102834 http://hdl.handle.net/2336/239051 Journal of immunology (Baltimore, Md. : 1950) |
op_rights |
Archived with thanks to Journal of immunology (Baltimore, Md. : 1950) Landspitali Access - LSH-aðgangur |
op_doi |
https://doi.org/10.4049/jimmunol.1102834 |
container_title |
The Journal of Immunology |
container_volume |
188 |
container_issue |
10 |
container_start_page |
5160 |
op_container_end_page |
5165 |
_version_ |
1766038827061739520 |