Retinopathy in old persons with and without diabetes mellitus: the Age, Gene/Environment Susceptibility--Reykjavik Study (AGES-R).

• Published in: Diabetologia
• Main Authors: Gunnlaugsdottir, E, Halldorsdottir, S, Klein, R, Eiriksdottir, G, Klein, B E, Benediktsson, R, Harris, T B, Launer, L J, Aspelund, T, Gudnason, V, Cotch, M F, Jonasson, F
• Other Authors: University Eye Department, Landspitali The National University Hospital, 101 Reykjavik, Iceland.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Springer 2012
• Subjects: Aged; 80 and over; Aging; Albuminuria; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Type 2; Diabetic Nephropathies; Diabetic Retinopathy; Female; Hemoglobin A; Glycosylated; Humans; Iceland; Macular Edema; Male; Prevalence; Retina; Retinal Diseases; Risk Factors; Severity of Illness Index
• Online Access: http://hdl.handle.net/2336/238396; https://doi.org/10.1007/s00125-011-2395-y

To access full text version of this article. Please click on the hyperlink "View/open" at the bottom of this page We aimed to describe the prevalence of retinopathy in an aged cohort of Icelanders with and without diabetes mellitus. The study population consisted of 4,994 persons aged ≥ 67 years, who participated in the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-R). Type 2 diabetes mellitus was defined as HbA(1c) ≥ 6.5% (>48 mmol/mol). Retinopathy was assessed by grading fundus photographs using the modified Airlie House adaptation of the Early Treatment Diabetic Retinopathy Study protocol. Associations between retinopathy and risk factors were estimated using odds ratios obtained from multivariate analyses. The overall prevalence of retinopathy in AGES-R was 12.4%. Diabetes mellitus was present in 516 persons (10.3%), for 512 of whom gradable fundus photos were available, including 138 persons (27.0%, 95% CI 23.2, 31.0) with any retinopathy. Five persons (1.0%, 95% CI 0.3, 2.3) had proliferative retinopathy. Clinically significant macular oedema was present in five persons (1.0%, 95% CI 0.3, 2.3). Independent risk factors for retinopathy in diabetic patients in a multivariate model included HbA(1c), insulin use and use of oral hypoglycaemic agents, the last two being indicators of longer disease duration. In 4478 participants without diabetes mellitus, gradable fundus photos were available for 4,453 participants, with retinopathy present in 476 (10.7%, 95% CI 9.8, 11.6) and clinically significant macular oedema in three persons. Independent risk factors included increasing age and microalbuminuria. Over three-quarters (78%) of retinopathy cases were found in persons without diabetes and a strong association between microalbuminuria and non-diabetic retinopathy was found. These results may have implications for patient management of the aged. NIH N01-AG-12100 NIH/NIA, National Eye Institute (NEI) of the NIH ZIAEY000401, Hjartavernd (the Icelandic Heart Association), Althingi (the Icelandic ...