The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Antimicrobial peptides are essential elements of epithelial defense against invading micro-organisms. The palatine tonsils are positioned at the entry of the airway and the gut and as such...
Published in: | Clinical Immunology |
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2012
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Online Access: | http://hdl.handle.net/2336/238368 https://doi.org/10.1016/j.clim.2011.09.013 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/238368 2023-05-15T16:51:12+02:00 The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells. Sigurdardottir, Sigrun L Thorleifsdottir, Ragna H Guzman, Andrew M Gudmundsson, Gudmundur H Valdimarsson, Helgi Johnston, Andrew Department of Immunology, Landspitali-University Hospital, Reykjavik, Iceland. 2012-08-14 http://hdl.handle.net/2336/238368 https://doi.org/10.1016/j.clim.2011.09.013 en eng Elsevier Science http://dx.doi.org/10.1016/j.clim.2011.09.013 Clin. Immunol. 2012, 142(2):139-49 1521-7035 22036268 doi:10.1016/j.clim.2011.09.013 http://hdl.handle.net/2336/238368 Clinical immunology (Orlando, Fla.) Archived with thanks to Clinical immunology (Orlando, Fla.) National Consortium - Landsaðgangur Antimicrobial Cationic Peptides Chemokine CXCL5 Chemokine CXCL9 Dendritic Cells Down-Regulation Epithelium GTP-Binding Proteins Humans Interferon-gamma Leukocytes Mononuclear Neutrophils Palatine Tonsil Receptors CCR4 CCR6 Up-Regulation Article Ónæmisfræði 2012 ftlandspitaliuni https://doi.org/10.1016/j.clim.2011.09.013 2022-05-29T08:21:49Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Antimicrobial peptides are essential elements of epithelial defense against invading micro-organisms. The palatine tonsils are positioned at the entry of the airway and the gut and as such are ideally situated to act as immune sentinels in the pharynx protecting against microbial invasion. Tonsils express a number of antimicrobial peptides including hCAP18/LL-37. Here we clearly define the expression of hCAP18/LL-37 in the tonsils showing unequivocally that hCAP18/LL-37 is mainly expressed by infiltrating neutrophils and follicular CD11c+CD13+HLA-DR+ dendritic cells, rarely by macrophages, and never by the epithelium itself. To explore possible functions for follicle-derived LL-37, we stimulated tonsil mononuclear cells with LL-37 in vitro and observed the secretion of the proinflammatory cytokines CCL5 and CXCL9, expression of IFN-γ and MX-1 and down-regulation of chemokine receptors CCR4 and CCR6 which are involved in tissue-selective T cell trafficking. Taken together, these data illustrate new potential immunoregulatory functions for hCAP18/LL-37 in the tonsils. Icelandic Research Fund 080448021-23, Landspitali University Hospital, University of Iceland, Babcock Endowment Fund Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Clinical Immunology 142 2 139 149 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Antimicrobial Cationic Peptides Chemokine CXCL5 Chemokine CXCL9 Dendritic Cells Down-Regulation Epithelium GTP-Binding Proteins Humans Interferon-gamma Leukocytes Mononuclear Neutrophils Palatine Tonsil Receptors CCR4 CCR6 Up-Regulation |
spellingShingle |
Antimicrobial Cationic Peptides Chemokine CXCL5 Chemokine CXCL9 Dendritic Cells Down-Regulation Epithelium GTP-Binding Proteins Humans Interferon-gamma Leukocytes Mononuclear Neutrophils Palatine Tonsil Receptors CCR4 CCR6 Up-Regulation Sigurdardottir, Sigrun L Thorleifsdottir, Ragna H Guzman, Andrew M Gudmundsson, Gudmundur H Valdimarsson, Helgi Johnston, Andrew The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells. |
topic_facet |
Antimicrobial Cationic Peptides Chemokine CXCL5 Chemokine CXCL9 Dendritic Cells Down-Regulation Epithelium GTP-Binding Proteins Humans Interferon-gamma Leukocytes Mononuclear Neutrophils Palatine Tonsil Receptors CCR4 CCR6 Up-Regulation |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Antimicrobial peptides are essential elements of epithelial defense against invading micro-organisms. The palatine tonsils are positioned at the entry of the airway and the gut and as such are ideally situated to act as immune sentinels in the pharynx protecting against microbial invasion. Tonsils express a number of antimicrobial peptides including hCAP18/LL-37. Here we clearly define the expression of hCAP18/LL-37 in the tonsils showing unequivocally that hCAP18/LL-37 is mainly expressed by infiltrating neutrophils and follicular CD11c+CD13+HLA-DR+ dendritic cells, rarely by macrophages, and never by the epithelium itself. To explore possible functions for follicle-derived LL-37, we stimulated tonsil mononuclear cells with LL-37 in vitro and observed the secretion of the proinflammatory cytokines CCL5 and CXCL9, expression of IFN-γ and MX-1 and down-regulation of chemokine receptors CCR4 and CCR6 which are involved in tissue-selective T cell trafficking. Taken together, these data illustrate new potential immunoregulatory functions for hCAP18/LL-37 in the tonsils. Icelandic Research Fund 080448021-23, Landspitali University Hospital, University of Iceland, Babcock Endowment Fund |
author2 |
Department of Immunology, Landspitali-University Hospital, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Sigurdardottir, Sigrun L Thorleifsdottir, Ragna H Guzman, Andrew M Gudmundsson, Gudmundur H Valdimarsson, Helgi Johnston, Andrew |
author_facet |
Sigurdardottir, Sigrun L Thorleifsdottir, Ragna H Guzman, Andrew M Gudmundsson, Gudmundur H Valdimarsson, Helgi Johnston, Andrew |
author_sort |
Sigurdardottir, Sigrun L |
title |
The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells. |
title_short |
The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells. |
title_full |
The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells. |
title_fullStr |
The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells. |
title_full_unstemmed |
The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells. |
title_sort |
anti-microbial peptide ll-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells. |
publisher |
Elsevier Science |
publishDate |
2012 |
url |
http://hdl.handle.net/2336/238368 https://doi.org/10.1016/j.clim.2011.09.013 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1016/j.clim.2011.09.013 Clin. Immunol. 2012, 142(2):139-49 1521-7035 22036268 doi:10.1016/j.clim.2011.09.013 http://hdl.handle.net/2336/238368 Clinical immunology (Orlando, Fla.) |
op_rights |
Archived with thanks to Clinical immunology (Orlando, Fla.) National Consortium - Landsaðgangur |
op_doi |
https://doi.org/10.1016/j.clim.2011.09.013 |
container_title |
Clinical Immunology |
container_volume |
142 |
container_issue |
2 |
container_start_page |
139 |
op_container_end_page |
149 |
_version_ |
1766041314157133824 |