Population-based incidence of exudative age-related macular degeneration and ranibizumab treatment load.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. BACKGROUND/AIMS: The use of intravitreal vascular endothelial growth factor antibodies for exudative age-related macular degeneration (AMD) has stressed ophthalmology services and drug bud...
Published in: | British Journal of Ophthalmology |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/237953 2023-05-15T16:47:18+02:00 Population-based incidence of exudative age-related macular degeneration and ranibizumab treatment load. Geirsdottir, Asbjorg Jonsson, Oskar Thorisdottir, Sigridur Helgadottir, Gudleif Jonasson, Fridbert Stefansson, Einar Sigurdsson, Haraldur Department of Ophthalmology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. 2012-08-09 http://hdl.handle.net/2336/237953 https://doi.org/10.1136/bjophthalmol-2011-300304 en eng http://dx.doi.org/10.1136/bjophthalmol-2011-300304 Br. J. Ophthalmol. 2012, 96(3):444-7 1468-2079 21856691 doi:10.1136/bjophthalmol-2011-300304 http://hdl.handle.net/2336/237953 British journal of ophthalmology Archived with thanks to The British journal of ophthalmology Landspitali Access - LSH-aðgangur Age Distribution Aged 80 and over Antibodies Monoclonal Humanized Drug Utilization Exudates and Transudates Female Follow-Up Studies Humans Iceland Incidence Intravitreal Injections Macular Degeneration Male Middle Aged Population Groups Prospective Studies Visual Acuity Article Augnlækningar 2012 ftlandspitaliuni https://doi.org/10.1136/bjophthalmol-2011-300304 2022-05-29T08:21:49Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. BACKGROUND/AIMS: The use of intravitreal vascular endothelial growth factor antibodies for exudative age-related macular degeneration (AMD) has stressed ophthalmology services and drug budgets throughout the world. The authors study the population-based incidence of exudative AMD in Iceland and the use of intravitreal ranibizumab in a defined population. METHODS: This is a prospective study of 439 consecutive patients aged 60 years and older with exudative AMD starting intravitreal ranibizumab for exudative AMD in Iceland from March 2007 to December 2009. All patients initially received three consecutive ranibizumab injections, with regular follow-up visits and re-treatment as needed. RESULTS: In total, 517 eyes from 439 patients received treatment for exudative AMD (mean age 79 years). The annual incidence of exudative AMD in the population 60 years and older is 0.29%. The incidence increased with advancing age, double for patients 85 years and older compared with those 75-79 years. Approximately 2400 ranibizumab injections per 100,000 persons aged 60 years and older were given each year for exudative AMD. CONCLUSIONS: These data allow an estimation of the incidence of exudative AMD in a Caucasian population and the treatment load with ranibizumab, which may help plan anti-vascular endothelial growth factor treatment programmes and estimate costs. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive British Journal of Ophthalmology 96 3 444 447 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Age Distribution Aged 80 and over Antibodies Monoclonal Humanized Drug Utilization Exudates and Transudates Female Follow-Up Studies Humans Iceland Incidence Intravitreal Injections Macular Degeneration Male Middle Aged Population Groups Prospective Studies Visual Acuity |
spellingShingle |
Age Distribution Aged 80 and over Antibodies Monoclonal Humanized Drug Utilization Exudates and Transudates Female Follow-Up Studies Humans Iceland Incidence Intravitreal Injections Macular Degeneration Male Middle Aged Population Groups Prospective Studies Visual Acuity Geirsdottir, Asbjorg Jonsson, Oskar Thorisdottir, Sigridur Helgadottir, Gudleif Jonasson, Fridbert Stefansson, Einar Sigurdsson, Haraldur Population-based incidence of exudative age-related macular degeneration and ranibizumab treatment load. |
topic_facet |
Age Distribution Aged 80 and over Antibodies Monoclonal Humanized Drug Utilization Exudates and Transudates Female Follow-Up Studies Humans Iceland Incidence Intravitreal Injections Macular Degeneration Male Middle Aged Population Groups Prospective Studies Visual Acuity |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. BACKGROUND/AIMS: The use of intravitreal vascular endothelial growth factor antibodies for exudative age-related macular degeneration (AMD) has stressed ophthalmology services and drug budgets throughout the world. The authors study the population-based incidence of exudative AMD in Iceland and the use of intravitreal ranibizumab in a defined population. METHODS: This is a prospective study of 439 consecutive patients aged 60 years and older with exudative AMD starting intravitreal ranibizumab for exudative AMD in Iceland from March 2007 to December 2009. All patients initially received three consecutive ranibizumab injections, with regular follow-up visits and re-treatment as needed. RESULTS: In total, 517 eyes from 439 patients received treatment for exudative AMD (mean age 79 years). The annual incidence of exudative AMD in the population 60 years and older is 0.29%. The incidence increased with advancing age, double for patients 85 years and older compared with those 75-79 years. Approximately 2400 ranibizumab injections per 100,000 persons aged 60 years and older were given each year for exudative AMD. CONCLUSIONS: These data allow an estimation of the incidence of exudative AMD in a Caucasian population and the treatment load with ranibizumab, which may help plan anti-vascular endothelial growth factor treatment programmes and estimate costs. |
author2 |
Department of Ophthalmology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Geirsdottir, Asbjorg Jonsson, Oskar Thorisdottir, Sigridur Helgadottir, Gudleif Jonasson, Fridbert Stefansson, Einar Sigurdsson, Haraldur |
author_facet |
Geirsdottir, Asbjorg Jonsson, Oskar Thorisdottir, Sigridur Helgadottir, Gudleif Jonasson, Fridbert Stefansson, Einar Sigurdsson, Haraldur |
author_sort |
Geirsdottir, Asbjorg |
title |
Population-based incidence of exudative age-related macular degeneration and ranibizumab treatment load. |
title_short |
Population-based incidence of exudative age-related macular degeneration and ranibizumab treatment load. |
title_full |
Population-based incidence of exudative age-related macular degeneration and ranibizumab treatment load. |
title_fullStr |
Population-based incidence of exudative age-related macular degeneration and ranibizumab treatment load. |
title_full_unstemmed |
Population-based incidence of exudative age-related macular degeneration and ranibizumab treatment load. |
title_sort |
population-based incidence of exudative age-related macular degeneration and ranibizumab treatment load. |
publishDate |
2012 |
url |
http://hdl.handle.net/2336/237953 https://doi.org/10.1136/bjophthalmol-2011-300304 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1136/bjophthalmol-2011-300304 Br. J. Ophthalmol. 2012, 96(3):444-7 1468-2079 21856691 doi:10.1136/bjophthalmol-2011-300304 http://hdl.handle.net/2336/237953 British journal of ophthalmology |
op_rights |
Archived with thanks to The British journal of ophthalmology Landspitali Access - LSH-aðgangur |
op_doi |
https://doi.org/10.1136/bjophthalmol-2011-300304 |
container_title |
British Journal of Ophthalmology |
container_volume |
96 |
container_issue |
3 |
container_start_page |
444 |
op_container_end_page |
447 |
_version_ |
1766037389718847488 |