Plasma n-3 and n-6 fatty acids and the incidence of atrial fibrillation following coronary artery bypass graft surgery.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. BACKGROUND: The anti-inflammatory or anti-arrhythmic effects of n-3 long-chain polyunsaturated fatty acids (LC-PUFA) may decrease the risk of postoperative atrial fibrillation (POAF), but...
Published in: | European Journal of Clinical Investigation |
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Online Access: | http://hdl.handle.net/2336/226474 https://doi.org/10.1111/j.1365-2362.2011.02497.x |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/226474 2023-05-15T16:49:39+02:00 Plasma n-3 and n-6 fatty acids and the incidence of atrial fibrillation following coronary artery bypass graft surgery. Skuladottir, Gudrun V Heidarsdottir, Ragnhildur Arnar, David O Torfason, Bjarni Edvardsson, Vidar Gottskalksson, Gizur Palsson, Runolfur Indridason, Olafur S Department of Physiology, School of Health Sciences, University of Iceland, Reykjavik, Iceland. gudrunvs@hi.is 2012-05-29 http://hdl.handle.net/2336/226474 https://doi.org/10.1111/j.1365-2362.2011.02497.x en eng Wiley http://dx.doi.org/10.1111/j.1365-2362.2011.02497.x Eur. J. Clin. Invest. 2011, 41(9):995-1003 1365-2362 21413975 doi:10.1111/j.1365-2362.2011.02497.x http://hdl.handle.net/2336/226474 European journal of clinical investigation Archived with thanks to European journal of clinical investigation Aged 80 and over Atrial Fibrillation C-Reactive Protein Coronary Artery Bypass Double-Blind Method Fatty Acids Omega-3 Omega-6 Female Humans Incidence Male Middle Aged Phospholipids Postoperative Complications Prospective Studies Article 2012 ftlandspitaliuni https://doi.org/10.1111/j.1365-2362.2011.02497.x 2022-05-29T08:21:48Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. BACKGROUND: The anti-inflammatory or anti-arrhythmic effects of n-3 long-chain polyunsaturated fatty acids (LC-PUFA) may decrease the risk of postoperative atrial fibrillation (POAF), but interventional studies have yielded conflicting results. We examined the association between n-3 LC-PUFA and n-6 LC-PUFA in plasma phospholipids (PL) and POAF in patients undergoing coronary artery bypass grafting (CABG). METHODS: A total of 125 patients undergoing CABG were enrolled in the study. The levels of fatty acids in PL were measured preoperatively and on the third postoperative day. The endpoint was defined as POAF lasting ≥5 min. The incidence of POAF was compared between quartiles of the level of each fatty acid in plasma PL by univariate and multivariable analysis. RESULTS: The incidence of POAF was 49·6%. By univariate analysis, the incidence of POAF increased significantly with each higher quartile of pre- and postoperative docosahexaenoic acid (DHA) and diminished significantly with each higher quartile of pre- and postoperative arachidonic acid (AA). For postoperative total n-3 LC-PUFA, there was a significant U-curve relationship where the second quartile had the lowest incidence of POAF or 25·8%. In multivariable analysis, this U-curve relationship between n-3 LC-PUFA levels and POAF risk was not significant, whereas the association between POAF and DHA or AA remained statistically significant. CONCLUSIONS: This study suggests that n-3 LC-PUFA supplements might prevent POAF in CABG patients with low baseline levels of these fatty acids in plasma PL, but may be harmful in those with high levels. AA may play an important role in electrophysiological processes. Icelandic Centre for Research (RANNIS) 080411021. University of Iceland. Landspitali - The National University Hospital of Iceland. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive European Journal of Clinical Investigation 41 9 995 1003 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Aged 80 and over Atrial Fibrillation C-Reactive Protein Coronary Artery Bypass Double-Blind Method Fatty Acids Omega-3 Omega-6 Female Humans Incidence Male Middle Aged Phospholipids Postoperative Complications Prospective Studies |
spellingShingle |
Aged 80 and over Atrial Fibrillation C-Reactive Protein Coronary Artery Bypass Double-Blind Method Fatty Acids Omega-3 Omega-6 Female Humans Incidence Male Middle Aged Phospholipids Postoperative Complications Prospective Studies Skuladottir, Gudrun V Heidarsdottir, Ragnhildur Arnar, David O Torfason, Bjarni Edvardsson, Vidar Gottskalksson, Gizur Palsson, Runolfur Indridason, Olafur S Plasma n-3 and n-6 fatty acids and the incidence of atrial fibrillation following coronary artery bypass graft surgery. |
topic_facet |
Aged 80 and over Atrial Fibrillation C-Reactive Protein Coronary Artery Bypass Double-Blind Method Fatty Acids Omega-3 Omega-6 Female Humans Incidence Male Middle Aged Phospholipids Postoperative Complications Prospective Studies |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. BACKGROUND: The anti-inflammatory or anti-arrhythmic effects of n-3 long-chain polyunsaturated fatty acids (LC-PUFA) may decrease the risk of postoperative atrial fibrillation (POAF), but interventional studies have yielded conflicting results. We examined the association between n-3 LC-PUFA and n-6 LC-PUFA in plasma phospholipids (PL) and POAF in patients undergoing coronary artery bypass grafting (CABG). METHODS: A total of 125 patients undergoing CABG were enrolled in the study. The levels of fatty acids in PL were measured preoperatively and on the third postoperative day. The endpoint was defined as POAF lasting ≥5 min. The incidence of POAF was compared between quartiles of the level of each fatty acid in plasma PL by univariate and multivariable analysis. RESULTS: The incidence of POAF was 49·6%. By univariate analysis, the incidence of POAF increased significantly with each higher quartile of pre- and postoperative docosahexaenoic acid (DHA) and diminished significantly with each higher quartile of pre- and postoperative arachidonic acid (AA). For postoperative total n-3 LC-PUFA, there was a significant U-curve relationship where the second quartile had the lowest incidence of POAF or 25·8%. In multivariable analysis, this U-curve relationship between n-3 LC-PUFA levels and POAF risk was not significant, whereas the association between POAF and DHA or AA remained statistically significant. CONCLUSIONS: This study suggests that n-3 LC-PUFA supplements might prevent POAF in CABG patients with low baseline levels of these fatty acids in plasma PL, but may be harmful in those with high levels. AA may play an important role in electrophysiological processes. Icelandic Centre for Research (RANNIS) 080411021. University of Iceland. Landspitali - The National University Hospital of Iceland. |
author2 |
Department of Physiology, School of Health Sciences, University of Iceland, Reykjavik, Iceland. gudrunvs@hi.is |
format |
Article in Journal/Newspaper |
author |
Skuladottir, Gudrun V Heidarsdottir, Ragnhildur Arnar, David O Torfason, Bjarni Edvardsson, Vidar Gottskalksson, Gizur Palsson, Runolfur Indridason, Olafur S |
author_facet |
Skuladottir, Gudrun V Heidarsdottir, Ragnhildur Arnar, David O Torfason, Bjarni Edvardsson, Vidar Gottskalksson, Gizur Palsson, Runolfur Indridason, Olafur S |
author_sort |
Skuladottir, Gudrun V |
title |
Plasma n-3 and n-6 fatty acids and the incidence of atrial fibrillation following coronary artery bypass graft surgery. |
title_short |
Plasma n-3 and n-6 fatty acids and the incidence of atrial fibrillation following coronary artery bypass graft surgery. |
title_full |
Plasma n-3 and n-6 fatty acids and the incidence of atrial fibrillation following coronary artery bypass graft surgery. |
title_fullStr |
Plasma n-3 and n-6 fatty acids and the incidence of atrial fibrillation following coronary artery bypass graft surgery. |
title_full_unstemmed |
Plasma n-3 and n-6 fatty acids and the incidence of atrial fibrillation following coronary artery bypass graft surgery. |
title_sort |
plasma n-3 and n-6 fatty acids and the incidence of atrial fibrillation following coronary artery bypass graft surgery. |
publisher |
Wiley |
publishDate |
2012 |
url |
http://hdl.handle.net/2336/226474 https://doi.org/10.1111/j.1365-2362.2011.02497.x |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1111/j.1365-2362.2011.02497.x Eur. J. Clin. Invest. 2011, 41(9):995-1003 1365-2362 21413975 doi:10.1111/j.1365-2362.2011.02497.x http://hdl.handle.net/2336/226474 European journal of clinical investigation |
op_rights |
Archived with thanks to European journal of clinical investigation |
op_doi |
https://doi.org/10.1111/j.1365-2362.2011.02497.x |
container_title |
European Journal of Clinical Investigation |
container_volume |
41 |
container_issue |
9 |
container_start_page |
995 |
op_container_end_page |
1003 |
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1766039809756758016 |