Chromophobe renal cell carcinoma in Iceland: an epidemiological and clinicopathological study.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. OBJECTIVE: Numerous studies have suggested that the rare chromophobe renal cell carcinoma (CRCC) has a more favourable prognosis than the other more common subtypes of RCC, clear cell RCC...
Published in: | Scandinavian Journal of Urology and Nephrology |
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Online Access: | http://hdl.handle.net/2336/225817 https://doi.org/10.3109/00365599.2011.579576 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/225817 2023-05-15T16:47:43+02:00 Chromophobe renal cell carcinoma in Iceland: an epidemiological and clinicopathological study. Ingimarsson, Johann P Hardarson, Sverrir Petursdottir, Vigdis Jonsson, Eirikur Einarsson, Gudmundur V Gudbjartsson, Tomas Department of Urology and Surgery, Landspitali University Hospital, Reykjavik, Iceland. 2012-05-24 http://hdl.handle.net/2336/225817 https://doi.org/10.3109/00365599.2011.579576 en eng Informa Healthcare http://dx.doi.org/10.3109/00365599.2011.579576 Scand. J. Urol. Nephrol. 2011, 45(5):306-11 1651-2065 21619417 doi:10.3109/00365599.2011.579576 http://hdl.handle.net/2336/225817 Scandinavian journal of urology and nephrology Archived with thanks to Scandinavian journal of urology and nephrology Carcinoma Renal Cell Female Humans Iceland Incidence Kidney Neoplasms Male Middle Aged Retrospective Studies Survival Rate Article 2012 ftlandspitaliuni https://doi.org/10.3109/00365599.2011.579576 2022-05-29T08:21:46Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. OBJECTIVE: Numerous studies have suggested that the rare chromophobe renal cell carcinoma (CRCC) has a more favourable prognosis than the other more common subtypes of RCC, clear cell RCC (CCRCC) and papillary RCC (PRCC). These studies have, however, usually involved selected patient cohorts and not whole populations. This study compared CRCC patients with patients with the other two major histological subtypes and established a population-based age-standardized incidence rate (ASR). MATERIAL AND METHODS: Of 828 histopathologically confirmed RCCs diagnosed between 1971 and 2005 in Iceland, 15 CRCC cases were identified. Histological material was reviewed, the TNM system was used for staging and cancer-specific survival was estimated. Univariate and multivariate analysis was used to compare CRCC to both CCRCC (n = 740) and PRCC (n = 66). Mean follow-up was 6.7 years. RESULTS: CRCC accounted for 1.8% of RCCs, the ASR being 0.17/100,000 per year. Compared to other subtypes, CRCC was detected incidentally less often (7% vs 29%, p = 0.02), but was more often diagnosed at lower stages (73% vs 45% at stage I + II, p < 0.001). One patient had synchronous metastasis and another developed recurrent CRCC; both died of CRCC. Five-year survival for CRCC, CCRCC and PRCC was 86%, 59% and 50%, respectively (p = 0.004). After correcting for TNM stage (odds ratio 1.98), multivariate analysis did not indicate that CRCC subtype was an independent predictive factor for survival. CONCLUSION: CRCC is a rare neoplasm with an ASR of 0.17/100,000 per year. These tumours often present with symptoms despite being at lower stages than the other RCC subtypes. The more favourable survival of the CRCC subtype appears to be explained by these tumours being diagnosed at low stages. These findings may suggest that CRCC has a different biological behaviour. Landspitali University Hospital Scientific Foundation Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive TNM ENVELOPE(-58.100,-58.100,-62.000,-62.000) Scandinavian Journal of Urology and Nephrology 45 5 306 311 |
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Hirsla - Landspítali University Hospital research archive |
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ftlandspitaliuni |
language |
English |
topic |
Carcinoma Renal Cell Female Humans Iceland Incidence Kidney Neoplasms Male Middle Aged Retrospective Studies Survival Rate |
spellingShingle |
Carcinoma Renal Cell Female Humans Iceland Incidence Kidney Neoplasms Male Middle Aged Retrospective Studies Survival Rate Ingimarsson, Johann P Hardarson, Sverrir Petursdottir, Vigdis Jonsson, Eirikur Einarsson, Gudmundur V Gudbjartsson, Tomas Chromophobe renal cell carcinoma in Iceland: an epidemiological and clinicopathological study. |
topic_facet |
Carcinoma Renal Cell Female Humans Iceland Incidence Kidney Neoplasms Male Middle Aged Retrospective Studies Survival Rate |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. OBJECTIVE: Numerous studies have suggested that the rare chromophobe renal cell carcinoma (CRCC) has a more favourable prognosis than the other more common subtypes of RCC, clear cell RCC (CCRCC) and papillary RCC (PRCC). These studies have, however, usually involved selected patient cohorts and not whole populations. This study compared CRCC patients with patients with the other two major histological subtypes and established a population-based age-standardized incidence rate (ASR). MATERIAL AND METHODS: Of 828 histopathologically confirmed RCCs diagnosed between 1971 and 2005 in Iceland, 15 CRCC cases were identified. Histological material was reviewed, the TNM system was used for staging and cancer-specific survival was estimated. Univariate and multivariate analysis was used to compare CRCC to both CCRCC (n = 740) and PRCC (n = 66). Mean follow-up was 6.7 years. RESULTS: CRCC accounted for 1.8% of RCCs, the ASR being 0.17/100,000 per year. Compared to other subtypes, CRCC was detected incidentally less often (7% vs 29%, p = 0.02), but was more often diagnosed at lower stages (73% vs 45% at stage I + II, p < 0.001). One patient had synchronous metastasis and another developed recurrent CRCC; both died of CRCC. Five-year survival for CRCC, CCRCC and PRCC was 86%, 59% and 50%, respectively (p = 0.004). After correcting for TNM stage (odds ratio 1.98), multivariate analysis did not indicate that CRCC subtype was an independent predictive factor for survival. CONCLUSION: CRCC is a rare neoplasm with an ASR of 0.17/100,000 per year. These tumours often present with symptoms despite being at lower stages than the other RCC subtypes. The more favourable survival of the CRCC subtype appears to be explained by these tumours being diagnosed at low stages. These findings may suggest that CRCC has a different biological behaviour. Landspitali University Hospital Scientific Foundation |
author2 |
Department of Urology and Surgery, Landspitali University Hospital, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Ingimarsson, Johann P Hardarson, Sverrir Petursdottir, Vigdis Jonsson, Eirikur Einarsson, Gudmundur V Gudbjartsson, Tomas |
author_facet |
Ingimarsson, Johann P Hardarson, Sverrir Petursdottir, Vigdis Jonsson, Eirikur Einarsson, Gudmundur V Gudbjartsson, Tomas |
author_sort |
Ingimarsson, Johann P |
title |
Chromophobe renal cell carcinoma in Iceland: an epidemiological and clinicopathological study. |
title_short |
Chromophobe renal cell carcinoma in Iceland: an epidemiological and clinicopathological study. |
title_full |
Chromophobe renal cell carcinoma in Iceland: an epidemiological and clinicopathological study. |
title_fullStr |
Chromophobe renal cell carcinoma in Iceland: an epidemiological and clinicopathological study. |
title_full_unstemmed |
Chromophobe renal cell carcinoma in Iceland: an epidemiological and clinicopathological study. |
title_sort |
chromophobe renal cell carcinoma in iceland: an epidemiological and clinicopathological study. |
publisher |
Informa Healthcare |
publishDate |
2012 |
url |
http://hdl.handle.net/2336/225817 https://doi.org/10.3109/00365599.2011.579576 |
long_lat |
ENVELOPE(-58.100,-58.100,-62.000,-62.000) |
geographic |
TNM |
geographic_facet |
TNM |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.3109/00365599.2011.579576 Scand. J. Urol. Nephrol. 2011, 45(5):306-11 1651-2065 21619417 doi:10.3109/00365599.2011.579576 http://hdl.handle.net/2336/225817 Scandinavian journal of urology and nephrology |
op_rights |
Archived with thanks to Scandinavian journal of urology and nephrology |
op_doi |
https://doi.org/10.3109/00365599.2011.579576 |
container_title |
Scandinavian Journal of Urology and Nephrology |
container_volume |
45 |
container_issue |
5 |
container_start_page |
306 |
op_container_end_page |
311 |
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1766037812085260288 |