No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. info:eu-repo/grantAgreement/EC/FP7/223423 The Autism Genome Project (AGP) Consortium recently reported genome-wide significant association between autism and an intronic single nucleotide...
Published in: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
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Online Access: | http://hdl.handle.net/2336/223514 https://doi.org/10.1002/ajmg.b.31201 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/223514 2023-05-15T16:51:49+02:00 No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. Curran, Sarah Bolton, Patrick Rozsnyai, Kinga Chiocchetti, Andreas Klauck, Sabine M Duketis, Eftichia Poustka, Fritz Schlitt, Sabine Freitag, Christine M Lee, Irene Muglia, Pierandrea Poot, Martin Staal, Wouter de Jonge, Maretha V Ophoff, Roel A Lewis, Cathryn Skuse, David Mandy, Will Vassos, Evangelos Fossdal, Ragnheidur Magnusson, Páll Hreidarsson, Stefan Saemundsen, Evald Stefansson, Hreinn Stefansson, Kari Collier, David Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Kings College London, UK. sarah.curran@kcl.ac.uk 2012-05-14 http://hdl.handle.net/2336/223514 https://doi.org/10.1002/ajmg.b.31201 en eng Wiley-Blackwell http://dx.doi.org/10.1002/ajmg.b.31201 Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011, 156B(6):633-9 1552-485X 21656903 doi:10.1002/ajmg.b.31201 http://hdl.handle.net/2336/223514 American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics Archived with thanks to American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics openAccess Autistic Disorder Case-Control Studies Europe Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Polymorphism Single Nucleotide Article 2012 ftlandspitaliuni https://doi.org/10.1002/ajmg.b.31201 2022-05-29T08:21:46Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. info:eu-repo/grantAgreement/EC/FP7/223423 The Autism Genome Project (AGP) Consortium recently reported genome-wide significant association between autism and an intronic single nucleotide polymorphism marker, rs4141463, within the MACROD2 gene. In the present study we attempted to replicate this finding using an independent case-control design of 1,170 cases with autism spectrum disorder (ASD) (874 of which fulfilled narrow criteria for Autism (A)) from five centers within Europe (UK, Germany, the Netherlands, Italy, and Iceland), and 35,307 controls. The combined sample size gave us a non-centrality parameter (NCP) of 11.9, with 93% power to detect allelic association of rs4141463 at an alpha of 0.05 with odds ratio of 0.84 (the best odds ratio estimate of the AGP Consortium data), and for the narrow diagnosis of autism, an NCP of 8.9 and power of 85%. Our case-control data were analyzed for association, stratified by each center, and the summary statistics were combined using the meta-analysis program, GWAMA. This resulted in an odds ratio (OR) of 1.03 (95% CI 0.944-1.133), with a P-value of 0.5 for ASD and OR of 0.99 (95% CI 0.88-1.11) with P-value = 0.85 for the Autism (A) sub-group. Therefore, this study does not provide support for the reported association between rs4141463 and autism. UK Medical Research Council G0500079 Deutsche Forschungsgemeinschaft info:eu-repo/grantAgreement/EC/FP7/223423 NIH MH071425 Netherlands Foundation for Brain Research (Hersenstichting) 2008(1).34 F2008(1) Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 6 633 639 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Autistic Disorder Case-Control Studies Europe Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Polymorphism Single Nucleotide |
spellingShingle |
Autistic Disorder Case-Control Studies Europe Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Polymorphism Single Nucleotide Curran, Sarah Bolton, Patrick Rozsnyai, Kinga Chiocchetti, Andreas Klauck, Sabine M Duketis, Eftichia Poustka, Fritz Schlitt, Sabine Freitag, Christine M Lee, Irene Muglia, Pierandrea Poot, Martin Staal, Wouter de Jonge, Maretha V Ophoff, Roel A Lewis, Cathryn Skuse, David Mandy, Will Vassos, Evangelos Fossdal, Ragnheidur Magnusson, Páll Hreidarsson, Stefan Saemundsen, Evald Stefansson, Hreinn Stefansson, Kari Collier, David No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. |
topic_facet |
Autistic Disorder Case-Control Studies Europe Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Polymorphism Single Nucleotide |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. info:eu-repo/grantAgreement/EC/FP7/223423 The Autism Genome Project (AGP) Consortium recently reported genome-wide significant association between autism and an intronic single nucleotide polymorphism marker, rs4141463, within the MACROD2 gene. In the present study we attempted to replicate this finding using an independent case-control design of 1,170 cases with autism spectrum disorder (ASD) (874 of which fulfilled narrow criteria for Autism (A)) from five centers within Europe (UK, Germany, the Netherlands, Italy, and Iceland), and 35,307 controls. The combined sample size gave us a non-centrality parameter (NCP) of 11.9, with 93% power to detect allelic association of rs4141463 at an alpha of 0.05 with odds ratio of 0.84 (the best odds ratio estimate of the AGP Consortium data), and for the narrow diagnosis of autism, an NCP of 8.9 and power of 85%. Our case-control data were analyzed for association, stratified by each center, and the summary statistics were combined using the meta-analysis program, GWAMA. This resulted in an odds ratio (OR) of 1.03 (95% CI 0.944-1.133), with a P-value of 0.5 for ASD and OR of 0.99 (95% CI 0.88-1.11) with P-value = 0.85 for the Autism (A) sub-group. Therefore, this study does not provide support for the reported association between rs4141463 and autism. UK Medical Research Council G0500079 Deutsche Forschungsgemeinschaft info:eu-repo/grantAgreement/EC/FP7/223423 NIH MH071425 Netherlands Foundation for Brain Research (Hersenstichting) 2008(1).34 F2008(1) |
author2 |
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Kings College London, UK. sarah.curran@kcl.ac.uk |
format |
Article in Journal/Newspaper |
author |
Curran, Sarah Bolton, Patrick Rozsnyai, Kinga Chiocchetti, Andreas Klauck, Sabine M Duketis, Eftichia Poustka, Fritz Schlitt, Sabine Freitag, Christine M Lee, Irene Muglia, Pierandrea Poot, Martin Staal, Wouter de Jonge, Maretha V Ophoff, Roel A Lewis, Cathryn Skuse, David Mandy, Will Vassos, Evangelos Fossdal, Ragnheidur Magnusson, Páll Hreidarsson, Stefan Saemundsen, Evald Stefansson, Hreinn Stefansson, Kari Collier, David |
author_facet |
Curran, Sarah Bolton, Patrick Rozsnyai, Kinga Chiocchetti, Andreas Klauck, Sabine M Duketis, Eftichia Poustka, Fritz Schlitt, Sabine Freitag, Christine M Lee, Irene Muglia, Pierandrea Poot, Martin Staal, Wouter de Jonge, Maretha V Ophoff, Roel A Lewis, Cathryn Skuse, David Mandy, Will Vassos, Evangelos Fossdal, Ragnheidur Magnusson, Páll Hreidarsson, Stefan Saemundsen, Evald Stefansson, Hreinn Stefansson, Kari Collier, David |
author_sort |
Curran, Sarah |
title |
No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. |
title_short |
No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. |
title_full |
No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. |
title_fullStr |
No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. |
title_full_unstemmed |
No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. |
title_sort |
no association between a common single nucleotide polymorphism, rs4141463, in the macrod2 gene and autism spectrum disorder. |
publisher |
Wiley-Blackwell |
publishDate |
2012 |
url |
http://hdl.handle.net/2336/223514 https://doi.org/10.1002/ajmg.b.31201 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1002/ajmg.b.31201 Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011, 156B(6):633-9 1552-485X 21656903 doi:10.1002/ajmg.b.31201 http://hdl.handle.net/2336/223514 American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics |
op_rights |
Archived with thanks to American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics openAccess |
op_doi |
https://doi.org/10.1002/ajmg.b.31201 |
container_title |
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
container_volume |
156 |
container_issue |
6 |
container_start_page |
633 |
op_container_end_page |
639 |
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1766041922705555456 |