Analysing the large decline in coronary heart disease mortality in the Icelandic population aged 25-74 between the years 1981 and 2006.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. BACKGROUND: Coronary heart disease (CHD) mortality rates have been decreasing in Iceland since the 1980s. We examined how much of the decrease between 1981 and 2006 could be attributed to...
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Online Access: | http://hdl.handle.net/2336/221829 https://doi.org/10.1371/journal.pone.0013957 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/221829 2023-05-15T16:47:14+02:00 Analysing the large decline in coronary heart disease mortality in the Icelandic population aged 25-74 between the years 1981 and 2006. Aspelund, Thor Gudnason, Vilmundur Magnusdottir, Bergrun Tinna Andersen, Karl Sigurdsson, Gunnar Thorsson, Bolli Steingrimsdottir, Laufey Critchley, Julia Bennett, Kathleen O'Flaherty, Martin Capewell, Simon Icelandic Heart Association, Kopavogur, Iceland. Landspitali National University Hospital, Reykjavik, Iceland. 2012-05-03 http://hdl.handle.net/2336/221829 https://doi.org/10.1371/journal.pone.0013957 en eng Public Library of Science http://dx.doi.org/10.1371/journal.pone.0013957 PLoS. ONE. 2010, 5(11):e13957 1932-6203 21103050 doi:10.1371/journal.pone.0013957 http://hdl.handle.net/2336/221829 PloS one Archived with thanks to PloS one Adult Aged Coronary Disease Female Humans Iceland Incidence Male Middle Aged Models Statistical Mortality Myocardial Infarction RÍN Hjartalæknisfræði Article 2012 ftlandspitaliuni https://doi.org/10.1371/journal.pone.0013957 2022-05-29T08:21:46Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. BACKGROUND: Coronary heart disease (CHD) mortality rates have been decreasing in Iceland since the 1980s. We examined how much of the decrease between 1981 and 2006 could be attributed to medical and surgical treatments and how much to changes in cardiovascular risk factors. METHODOLOGY: The previously validated IMPACT CHD mortality model was applied to the Icelandic population. The data sources were official statistics, national quality registers, published trials and meta-analyses, clinical audits and a series of national population surveys. PRINCIPAL FINDINGS: Between 1981 and 2006, CHD mortality rates in Iceland decreased by 80% in men and women aged 25 to 74 years, which resulted in 295 fewer deaths in 2006 than if the 1981 rates had persisted. Incidence of myocardial infarction (MI) decreased by 66% and resulted in some 500 fewer incident MI cases per year, which is a major determinant of possible deaths from MI. Based on the IMPACT model approximately 73% (lower and upper bound estimates: 54%-93%) of the mortality decrease was attributable to risk factor reductions: cholesterol 32%; smoking 22%; systolic blood pressure 22%, and physical inactivity 5% with adverse trends for diabetes (-5%), and obesity (-4%). Approximately 25% (lower and upper bound estimates: 8%-40%) of the mortality decrease was attributable to treatments in individuals: secondary prevention 8%; heart failure treatments 6%; acute coronary syndrome treatments 5%; revascularisation 3%; hypertension treatments 2%, and statins 0.5%. CONCLUSIONS: Almost three quarters of the large CHD mortality decrease in Iceland between 1981 and 2006 was attributable to reductions in major cardiovascular risk factors in the population. These findings emphasize the value of a comprehensive prevention strategy that promotes tobacco control and a healthier diet to reduce incidence of MI and highlights the potential importance of effective, evidence ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive PLoS ONE 5 11 e13957 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adult Aged Coronary Disease Female Humans Iceland Incidence Male Middle Aged Models Statistical Mortality Myocardial Infarction RÍN Hjartalæknisfræði |
spellingShingle |
Adult Aged Coronary Disease Female Humans Iceland Incidence Male Middle Aged Models Statistical Mortality Myocardial Infarction RÍN Hjartalæknisfræði Aspelund, Thor Gudnason, Vilmundur Magnusdottir, Bergrun Tinna Andersen, Karl Sigurdsson, Gunnar Thorsson, Bolli Steingrimsdottir, Laufey Critchley, Julia Bennett, Kathleen O'Flaherty, Martin Capewell, Simon Analysing the large decline in coronary heart disease mortality in the Icelandic population aged 25-74 between the years 1981 and 2006. |
topic_facet |
Adult Aged Coronary Disease Female Humans Iceland Incidence Male Middle Aged Models Statistical Mortality Myocardial Infarction RÍN Hjartalæknisfræði |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. BACKGROUND: Coronary heart disease (CHD) mortality rates have been decreasing in Iceland since the 1980s. We examined how much of the decrease between 1981 and 2006 could be attributed to medical and surgical treatments and how much to changes in cardiovascular risk factors. METHODOLOGY: The previously validated IMPACT CHD mortality model was applied to the Icelandic population. The data sources were official statistics, national quality registers, published trials and meta-analyses, clinical audits and a series of national population surveys. PRINCIPAL FINDINGS: Between 1981 and 2006, CHD mortality rates in Iceland decreased by 80% in men and women aged 25 to 74 years, which resulted in 295 fewer deaths in 2006 than if the 1981 rates had persisted. Incidence of myocardial infarction (MI) decreased by 66% and resulted in some 500 fewer incident MI cases per year, which is a major determinant of possible deaths from MI. Based on the IMPACT model approximately 73% (lower and upper bound estimates: 54%-93%) of the mortality decrease was attributable to risk factor reductions: cholesterol 32%; smoking 22%; systolic blood pressure 22%, and physical inactivity 5% with adverse trends for diabetes (-5%), and obesity (-4%). Approximately 25% (lower and upper bound estimates: 8%-40%) of the mortality decrease was attributable to treatments in individuals: secondary prevention 8%; heart failure treatments 6%; acute coronary syndrome treatments 5%; revascularisation 3%; hypertension treatments 2%, and statins 0.5%. CONCLUSIONS: Almost three quarters of the large CHD mortality decrease in Iceland between 1981 and 2006 was attributable to reductions in major cardiovascular risk factors in the population. These findings emphasize the value of a comprehensive prevention strategy that promotes tobacco control and a healthier diet to reduce incidence of MI and highlights the potential importance of effective, evidence ... |
author2 |
Icelandic Heart Association, Kopavogur, Iceland. Landspitali National University Hospital, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Aspelund, Thor Gudnason, Vilmundur Magnusdottir, Bergrun Tinna Andersen, Karl Sigurdsson, Gunnar Thorsson, Bolli Steingrimsdottir, Laufey Critchley, Julia Bennett, Kathleen O'Flaherty, Martin Capewell, Simon |
author_facet |
Aspelund, Thor Gudnason, Vilmundur Magnusdottir, Bergrun Tinna Andersen, Karl Sigurdsson, Gunnar Thorsson, Bolli Steingrimsdottir, Laufey Critchley, Julia Bennett, Kathleen O'Flaherty, Martin Capewell, Simon |
author_sort |
Aspelund, Thor |
title |
Analysing the large decline in coronary heart disease mortality in the Icelandic population aged 25-74 between the years 1981 and 2006. |
title_short |
Analysing the large decline in coronary heart disease mortality in the Icelandic population aged 25-74 between the years 1981 and 2006. |
title_full |
Analysing the large decline in coronary heart disease mortality in the Icelandic population aged 25-74 between the years 1981 and 2006. |
title_fullStr |
Analysing the large decline in coronary heart disease mortality in the Icelandic population aged 25-74 between the years 1981 and 2006. |
title_full_unstemmed |
Analysing the large decline in coronary heart disease mortality in the Icelandic population aged 25-74 between the years 1981 and 2006. |
title_sort |
analysing the large decline in coronary heart disease mortality in the icelandic population aged 25-74 between the years 1981 and 2006. |
publisher |
Public Library of Science |
publishDate |
2012 |
url |
http://hdl.handle.net/2336/221829 https://doi.org/10.1371/journal.pone.0013957 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1371/journal.pone.0013957 PLoS. ONE. 2010, 5(11):e13957 1932-6203 21103050 doi:10.1371/journal.pone.0013957 http://hdl.handle.net/2336/221829 PloS one |
op_rights |
Archived with thanks to PloS one |
op_doi |
https://doi.org/10.1371/journal.pone.0013957 |
container_title |
PLoS ONE |
container_volume |
5 |
container_issue |
11 |
container_start_page |
e13957 |
_version_ |
1766037314428993536 |