Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field To determine if neuregulin 1 (NRG1) is associated with schizophrenia in Asian populations, we investigated a Han Chinese population using both a family trio design and a case-control design...
Published in: | Molecular Psychiatry |
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Language: | English |
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Online Access: | http://hdl.handle.net/2336/21992 https://doi.org/10.1038/sj.mp.4001485 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/21992 2023-05-15T16:52:20+02:00 Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. Li, T Stefansson, H Gudfinnsson, E Cai, G Liu, X Murray, R M Steinthorsdottir, V Januel, D Gudnadottir, V G Petursson, H Ingason, A Gulcher, J R Stefansson, K Collier, D A 2008-03-31 http://hdl.handle.net/2336/21992 https://doi.org/10.1038/sj.mp.4001485 en eng Nature Publishing Group Specialist Journals http://dx.doi.org/10.1038/sj.mp.4001485 Mol. Psychiatry 2004, 9(7):698-704 1359-4184 15007393 doi:10.1038/sj.mp.4001485 http://hdl.handle.net/2336/21992 Molecular psychiatry Asian Continental Ancestry Group Case-Control Studies China European Continental Ancestry Group Genetic Markers Genetic Predisposition to Disease Haplotypes Humans Iceland Neuregulin-1 Risk Factors Schizophrenia Scotland Article 2008 ftlandspitaliuni https://doi.org/10.1038/sj.mp.4001485 2022-05-29T08:21:07Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field To determine if neuregulin 1 (NRG1) is associated with schizophrenia in Asian populations, we investigated a Han Chinese population using both a family trio design and a case-control design. A total of 25 microsatellite markers and single nucleotide polymorphisms (SNPs) were genotyped spanning the 1.1 Mb NRG1 gene including markers of a seven-marker haplotype at the 5' end of the gene found to be in excess in Icelandic and Scottish schizophrenia patients. The alleles of the individual markers forming the seven marker at-risk haplotype are not likely to be causative as they are not in excess in patients in the Chinese population studied here. However using unrelated patients, we find a novel haplotype (HAP(China 1)), immediately upstream of the Icelandic haplotype, in excess in patients (11.9% in patients vs 4.2% in controls; P=0.0000065, risk ratio (rr) 3.1), which was not significant when parental controls were used. Another haplotype (HAP(China 2)) overlapping the Icelandic risk haplotype was found in excess in the Chinese (8.5% of patients vs 4.0% of unrelated controls; P=0.003, rr 2.2) and was also significant using parental controls only (P=0.0047, rr 2.1). A four-marker haplotype at the 3' end of the NRG1 gene, HAP(China 3), was found at a frequency of 23.8% in patients and 13.7% in nontransmitted parental haplotypes (P=0.000042, rr=2.0) but was not significant in the case-control comparison. We conclude that different haplotypes within the boundaries of the NRG1 gene may be associated with schizophrenia in the Han Chinese. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Molecular Psychiatry 9 7 698 704 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Asian Continental Ancestry Group Case-Control Studies China European Continental Ancestry Group Genetic Markers Genetic Predisposition to Disease Haplotypes Humans Iceland Neuregulin-1 Risk Factors Schizophrenia Scotland |
spellingShingle |
Asian Continental Ancestry Group Case-Control Studies China European Continental Ancestry Group Genetic Markers Genetic Predisposition to Disease Haplotypes Humans Iceland Neuregulin-1 Risk Factors Schizophrenia Scotland Li, T Stefansson, H Gudfinnsson, E Cai, G Liu, X Murray, R M Steinthorsdottir, V Januel, D Gudnadottir, V G Petursson, H Ingason, A Gulcher, J R Stefansson, K Collier, D A Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. |
topic_facet |
Asian Continental Ancestry Group Case-Control Studies China European Continental Ancestry Group Genetic Markers Genetic Predisposition to Disease Haplotypes Humans Iceland Neuregulin-1 Risk Factors Schizophrenia Scotland |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field To determine if neuregulin 1 (NRG1) is associated with schizophrenia in Asian populations, we investigated a Han Chinese population using both a family trio design and a case-control design. A total of 25 microsatellite markers and single nucleotide polymorphisms (SNPs) were genotyped spanning the 1.1 Mb NRG1 gene including markers of a seven-marker haplotype at the 5' end of the gene found to be in excess in Icelandic and Scottish schizophrenia patients. The alleles of the individual markers forming the seven marker at-risk haplotype are not likely to be causative as they are not in excess in patients in the Chinese population studied here. However using unrelated patients, we find a novel haplotype (HAP(China 1)), immediately upstream of the Icelandic haplotype, in excess in patients (11.9% in patients vs 4.2% in controls; P=0.0000065, risk ratio (rr) 3.1), which was not significant when parental controls were used. Another haplotype (HAP(China 2)) overlapping the Icelandic risk haplotype was found in excess in the Chinese (8.5% of patients vs 4.0% of unrelated controls; P=0.003, rr 2.2) and was also significant using parental controls only (P=0.0047, rr 2.1). A four-marker haplotype at the 3' end of the NRG1 gene, HAP(China 3), was found at a frequency of 23.8% in patients and 13.7% in nontransmitted parental haplotypes (P=0.000042, rr=2.0) but was not significant in the case-control comparison. We conclude that different haplotypes within the boundaries of the NRG1 gene may be associated with schizophrenia in the Han Chinese. |
format |
Article in Journal/Newspaper |
author |
Li, T Stefansson, H Gudfinnsson, E Cai, G Liu, X Murray, R M Steinthorsdottir, V Januel, D Gudnadottir, V G Petursson, H Ingason, A Gulcher, J R Stefansson, K Collier, D A |
author_facet |
Li, T Stefansson, H Gudfinnsson, E Cai, G Liu, X Murray, R M Steinthorsdottir, V Januel, D Gudnadottir, V G Petursson, H Ingason, A Gulcher, J R Stefansson, K Collier, D A |
author_sort |
Li, T |
title |
Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. |
title_short |
Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. |
title_full |
Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. |
title_fullStr |
Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. |
title_full_unstemmed |
Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. |
title_sort |
identification of a novel neuregulin 1 at-risk haplotype in han schizophrenia chinese patients, but no association with the icelandic/scottish risk haplotype. |
publisher |
Nature Publishing Group Specialist Journals |
publishDate |
2008 |
url |
http://hdl.handle.net/2336/21992 https://doi.org/10.1038/sj.mp.4001485 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1038/sj.mp.4001485 Mol. Psychiatry 2004, 9(7):698-704 1359-4184 15007393 doi:10.1038/sj.mp.4001485 http://hdl.handle.net/2336/21992 Molecular psychiatry |
op_doi |
https://doi.org/10.1038/sj.mp.4001485 |
container_title |
Molecular Psychiatry |
container_volume |
9 |
container_issue |
7 |
container_start_page |
698 |
op_container_end_page |
704 |
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1766042474097147904 |