Síðkomnar og langvinnar aukaverkanir eftir hvítblæðismeðferð í æsku
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open Introduction: The treatment of childhood leukemia has improved substantially over the last decades and now 65-75% of the patients recover. With increasing number of survivors it is important to know the...
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Læknafélag Íslands, Læknafélag Reykjavíkur
2008
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/16314 2023-05-15T16:48:03+02:00 Síðkomnar og langvinnar aukaverkanir eftir hvítblæðismeðferð í æsku Late and long-term effects of leukaemia treatment in childhood Valur Helgi Kristinsson Jón R. Kristinsson Guðmundur Kr. Jónmundsson Ólafur Gísli Jónsson Árni V. Þórsson Ásgeir Haraldsson 2008-01-18 http://hdl.handle.net/2336/16314 ICE is ice Læknafélag Íslands, Læknafélag Reykjavíkur http://www.laeknabladid.is/2002/1/fraedigreinar/nr/724/ Læknablaðið 2002, 88(1):13-8 0023-7213 16940660 http://hdl.handle.net/2336/16314 Læknablaðið Aukaverkanir Börn Hvítblæði Krabbamein Meðferð LBL12 Leukemia Child Article 2008 ftlandspitaliuni 2022-05-29T08:21:04Z Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open Introduction: The treatment of childhood leukemia has improved substantially over the last decades and now 65-75% of the patients recover. With increasing number of survivors it is important to know the long-term and late effects of leukemia and leukaemia treatment. Patients: Of the 31 children diagnosed with leukemia in Iceland from 1981 to 1990, twenty were enrolled in the study. Average age at enrollment was16 years and 8 months (16:8) and average time since treatment ended was 8:3. Methods: The study was carried out at the Children's Hospital at the University Hospital Iceland where patients were examined and data was gathered on height, weight, hearing, cognitive functions, bloodvalues, immunoglobulins and renal, endocrine, heart, liver and respiratory functions. Results: The children studied were on average 0.48 standard deviations below target height and their body-mass index was higher at the time of study than at diagnosis. Two children had obvious obstructive lung disease. No abnormalities were found in complete blood count nor heart, liver or kidney functions. Two patients were found to have impaired hearing not attributable to acoustic trauma. In some cases abnormal values were found in immunoglobulin classes and 12 patients had decreased serum IgG2. Six needed remedial reading lessons. Three patients needed hormone replacement therapy. Discussion: Minor impact on height and weight was found but the effects on lungs and hearing were inconclusive. Despite markedly decreased serum IgG2 the patients were not more prone to infections. The most obvious effects were on the endocrine system and performance at school. We conclude that the sequelae of childhood leukemia treatment in Iceland are significant and long-lasting, underlining the necessity of a careful long-term follow-up. Inngangur: Fyrir 30 árum var hvítblæði í flestum tilvikum banvænn sjúkdómur í börnum. Síðan þá hefur árangur meðferðar batnað til ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Smella ENVELOPE(29.443,29.443,69.896,69.896) |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
Icelandic |
topic |
Aukaverkanir Börn Hvítblæði Krabbamein Meðferð LBL12 Leukemia Child |
spellingShingle |
Aukaverkanir Börn Hvítblæði Krabbamein Meðferð LBL12 Leukemia Child Valur Helgi Kristinsson Jón R. Kristinsson Guðmundur Kr. Jónmundsson Ólafur Gísli Jónsson Árni V. Þórsson Ásgeir Haraldsson Síðkomnar og langvinnar aukaverkanir eftir hvítblæðismeðferð í æsku |
topic_facet |
Aukaverkanir Börn Hvítblæði Krabbamein Meðferð LBL12 Leukemia Child |
description |
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open Introduction: The treatment of childhood leukemia has improved substantially over the last decades and now 65-75% of the patients recover. With increasing number of survivors it is important to know the long-term and late effects of leukemia and leukaemia treatment. Patients: Of the 31 children diagnosed with leukemia in Iceland from 1981 to 1990, twenty were enrolled in the study. Average age at enrollment was16 years and 8 months (16:8) and average time since treatment ended was 8:3. Methods: The study was carried out at the Children's Hospital at the University Hospital Iceland where patients were examined and data was gathered on height, weight, hearing, cognitive functions, bloodvalues, immunoglobulins and renal, endocrine, heart, liver and respiratory functions. Results: The children studied were on average 0.48 standard deviations below target height and their body-mass index was higher at the time of study than at diagnosis. Two children had obvious obstructive lung disease. No abnormalities were found in complete blood count nor heart, liver or kidney functions. Two patients were found to have impaired hearing not attributable to acoustic trauma. In some cases abnormal values were found in immunoglobulin classes and 12 patients had decreased serum IgG2. Six needed remedial reading lessons. Three patients needed hormone replacement therapy. Discussion: Minor impact on height and weight was found but the effects on lungs and hearing were inconclusive. Despite markedly decreased serum IgG2 the patients were not more prone to infections. The most obvious effects were on the endocrine system and performance at school. We conclude that the sequelae of childhood leukemia treatment in Iceland are significant and long-lasting, underlining the necessity of a careful long-term follow-up. Inngangur: Fyrir 30 árum var hvítblæði í flestum tilvikum banvænn sjúkdómur í börnum. Síðan þá hefur árangur meðferðar batnað til ... |
format |
Article in Journal/Newspaper |
author |
Valur Helgi Kristinsson Jón R. Kristinsson Guðmundur Kr. Jónmundsson Ólafur Gísli Jónsson Árni V. Þórsson Ásgeir Haraldsson |
author_facet |
Valur Helgi Kristinsson Jón R. Kristinsson Guðmundur Kr. Jónmundsson Ólafur Gísli Jónsson Árni V. Þórsson Ásgeir Haraldsson |
author_sort |
Valur Helgi Kristinsson |
title |
Síðkomnar og langvinnar aukaverkanir eftir hvítblæðismeðferð í æsku |
title_short |
Síðkomnar og langvinnar aukaverkanir eftir hvítblæðismeðferð í æsku |
title_full |
Síðkomnar og langvinnar aukaverkanir eftir hvítblæðismeðferð í æsku |
title_fullStr |
Síðkomnar og langvinnar aukaverkanir eftir hvítblæðismeðferð í æsku |
title_full_unstemmed |
Síðkomnar og langvinnar aukaverkanir eftir hvítblæðismeðferð í æsku |
title_sort |
síðkomnar og langvinnar aukaverkanir eftir hvítblæðismeðferð í æsku |
publisher |
Læknafélag Íslands, Læknafélag Reykjavíkur |
publishDate |
2008 |
url |
http://hdl.handle.net/2336/16314 |
long_lat |
ENVELOPE(29.443,29.443,69.896,69.896) |
geographic |
Smella |
geographic_facet |
Smella |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.laeknabladid.is/2002/1/fraedigreinar/nr/724/ Læknablaðið 2002, 88(1):13-8 0023-7213 16940660 http://hdl.handle.net/2336/16314 Læknablaðið |
_version_ |
1766038143957467136 |