Anxiety with panic disorder linked to chromosome 9q in Iceland
To access publisher version of this article. Please click on the hyperlink in Additional Links field To access full text version of this article. Please click on the hyperlink "View/Open" at the bottom of this page The results of a genomewide scan for genes conferring susceptibility to anx...
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Online Access: | http://hdl.handle.net/2336/14690 https://doi.org/10.1086/375141 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/14690 2023-05-15T16:48:44+02:00 Anxiety with panic disorder linked to chromosome 9q in Iceland Thorgeirsson, Thorgeir E Oskarsson, Högni Desnica, Natasa Kostic, Jelena Pop Stefansson, Jon G Kolbeinsson, Halldor Lindal, Eirikur Gagunashvili, Nikolai Frigge, Michael L Kong, Augustine Stefansson, Kari Gulcher, Jeffrey R deCode Genetics, Reykjavík, Iceland. thorgeir@decode.is 2007-11-22 YES http://hdl.handle.net/2336/14690 https://doi.org/10.1086/375141 en eng University of Chicago Press http://www.journals.uchicago.edu/doi/abs/10.1086/375141 Am. J. Hum. Genet. 2003, 72(5):1221-30 0002-9297 12679899 doi:10.1086/375141 http://hdl.handle.net/2336/14690 American journal of human genetics Anxiety Chromosomes Human Pair 9 Genetic Predisposition to Disease Iceland Linkage (Genetics) Panic Disorder Microsatellite Repeats Questionnaires Article 2007 ftlandspitaliuni https://doi.org/10.1086/375141 2022-05-29T08:21:03Z To access publisher version of this article. Please click on the hyperlink in Additional Links field To access full text version of this article. Please click on the hyperlink "View/Open" at the bottom of this page The results of a genomewide scan for genes conferring susceptibility to anxiety disorders in the Icelandic population are described. The aim of the study was to locate genes that predispose to anxiety by utilizing the extensive genealogical records and the relative homogeneity of the Icelandic population. Participants were recruited in two stages: (1) Initial case-identification by a population screening for anxiety disorders, using the Stamm Screening Questionnaire, was followed by aggregation into extended families, with the help of our genealogy database; and (2) those who fulfilled the diagnostic and family aggregation criteria underwent a more detailed diagnostic workup based on the Composite International Diagnostic Interview. Screening for anxiety in close relatives also identified additional affected members within the families. After genotyping was performed with 976 microsatellite markers, affected-only linkage analysis was done, and allele-sharing LOD scores were calculated using the program Allegro. Linkage analysis of 25 extended families, in each of which at least one affected individual had panic disorder (PD), resulted in a LOD score of 4.18 at D9S271, on chromosome 9q31. The intermarker distance was 4.4 cM on average, whereas it was 1.5 cM in the linked region as additional markers were added to increase the information content. The linkage results may be relevant not only to PD but also to anxiety in general, since our linkage study included patients with other forms of anxiety. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive The American Journal of Human Genetics 72 5 1221 1230 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Anxiety Chromosomes Human Pair 9 Genetic Predisposition to Disease Iceland Linkage (Genetics) Panic Disorder Microsatellite Repeats Questionnaires |
spellingShingle |
Anxiety Chromosomes Human Pair 9 Genetic Predisposition to Disease Iceland Linkage (Genetics) Panic Disorder Microsatellite Repeats Questionnaires Thorgeirsson, Thorgeir E Oskarsson, Högni Desnica, Natasa Kostic, Jelena Pop Stefansson, Jon G Kolbeinsson, Halldor Lindal, Eirikur Gagunashvili, Nikolai Frigge, Michael L Kong, Augustine Stefansson, Kari Gulcher, Jeffrey R Anxiety with panic disorder linked to chromosome 9q in Iceland |
topic_facet |
Anxiety Chromosomes Human Pair 9 Genetic Predisposition to Disease Iceland Linkage (Genetics) Panic Disorder Microsatellite Repeats Questionnaires |
description |
To access publisher version of this article. Please click on the hyperlink in Additional Links field To access full text version of this article. Please click on the hyperlink "View/Open" at the bottom of this page The results of a genomewide scan for genes conferring susceptibility to anxiety disorders in the Icelandic population are described. The aim of the study was to locate genes that predispose to anxiety by utilizing the extensive genealogical records and the relative homogeneity of the Icelandic population. Participants were recruited in two stages: (1) Initial case-identification by a population screening for anxiety disorders, using the Stamm Screening Questionnaire, was followed by aggregation into extended families, with the help of our genealogy database; and (2) those who fulfilled the diagnostic and family aggregation criteria underwent a more detailed diagnostic workup based on the Composite International Diagnostic Interview. Screening for anxiety in close relatives also identified additional affected members within the families. After genotyping was performed with 976 microsatellite markers, affected-only linkage analysis was done, and allele-sharing LOD scores were calculated using the program Allegro. Linkage analysis of 25 extended families, in each of which at least one affected individual had panic disorder (PD), resulted in a LOD score of 4.18 at D9S271, on chromosome 9q31. The intermarker distance was 4.4 cM on average, whereas it was 1.5 cM in the linked region as additional markers were added to increase the information content. The linkage results may be relevant not only to PD but also to anxiety in general, since our linkage study included patients with other forms of anxiety. |
author2 |
deCode Genetics, Reykjavík, Iceland. thorgeir@decode.is |
format |
Article in Journal/Newspaper |
author |
Thorgeirsson, Thorgeir E Oskarsson, Högni Desnica, Natasa Kostic, Jelena Pop Stefansson, Jon G Kolbeinsson, Halldor Lindal, Eirikur Gagunashvili, Nikolai Frigge, Michael L Kong, Augustine Stefansson, Kari Gulcher, Jeffrey R |
author_facet |
Thorgeirsson, Thorgeir E Oskarsson, Högni Desnica, Natasa Kostic, Jelena Pop Stefansson, Jon G Kolbeinsson, Halldor Lindal, Eirikur Gagunashvili, Nikolai Frigge, Michael L Kong, Augustine Stefansson, Kari Gulcher, Jeffrey R |
author_sort |
Thorgeirsson, Thorgeir E |
title |
Anxiety with panic disorder linked to chromosome 9q in Iceland |
title_short |
Anxiety with panic disorder linked to chromosome 9q in Iceland |
title_full |
Anxiety with panic disorder linked to chromosome 9q in Iceland |
title_fullStr |
Anxiety with panic disorder linked to chromosome 9q in Iceland |
title_full_unstemmed |
Anxiety with panic disorder linked to chromosome 9q in Iceland |
title_sort |
anxiety with panic disorder linked to chromosome 9q in iceland |
publisher |
University of Chicago Press |
publishDate |
2007 |
url |
http://hdl.handle.net/2336/14690 https://doi.org/10.1086/375141 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.journals.uchicago.edu/doi/abs/10.1086/375141 Am. J. Hum. Genet. 2003, 72(5):1221-30 0002-9297 12679899 doi:10.1086/375141 http://hdl.handle.net/2336/14690 American journal of human genetics |
op_doi |
https://doi.org/10.1086/375141 |
container_title |
The American Journal of Human Genetics |
container_volume |
72 |
container_issue |
5 |
container_start_page |
1221 |
op_container_end_page |
1230 |
_version_ |
1766038820378116096 |