Beina- og kalkbúskapur sjúklinga með herslismein
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open AIMS: To elucidate bone mineral density (BMD) and bone turnover in an un-selected group of patients with Systemic Sclerosis (SSc) in national based registry. MATERIAL AND METHODS: All patients who have b...
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Læknafélag Íslands, Læknafélag Reykjavíkur
2007
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/13864 2023-05-15T16:47:43+02:00 Beina- og kalkbúskapur sjúklinga með herslismein Bone mineral density and bone turnover in systemic sclerosis Bjarki Þór Alexandersson Árni Jón Geirsson Ísleifur Ólafsson Leifur Franzson Gunnar Sigurðsson Björn Guðbjörnsson 2007-10-01 164432 bytes application/pdf YES http://hdl.handle.net/2336/13864 ice is ice Læknafélag Íslands, Læknafélag Reykjavíkur http://www.laeknabladid.is Læknablaðið 2007, 93(7-8):535-41 0023-7213 17823496 http://hdl.handle.net/2336/13864 Læknablaðið Herslismein Beinþynning LBL12 Bone Density Bone Diseases Metabolic Calcium Densitometry X-Ray Iceland Osteoporosis Scleroderma Systemic Article 2007 ftlandspitaliuni 2022-05-29T08:21:02Z Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open AIMS: To elucidate bone mineral density (BMD) and bone turnover in an un-selected group of patients with Systemic Sclerosis (SSc) in national based registry. MATERIAL AND METHODS: All patients who have been diagnosed with SSc in Iceland were invited to participate in the study. Participants underwent standardized interview and delivered urine and blood samples for measurements of various bone metabolites (e.g. PTH, osteocalcin, Cross Laps, PINP, IGF-1, Cystatin-C and 25-OH-vitamin-D), before they underwent measurement of BMD with DEXA (QDR 4500 Elite). RESULTS: Twenty-four individuals, 20 female and four male, of 29 diagnosed patients with SSc in Iceland accepted to participate in the study (83%). The mean age was 60 +/- 15 years. Seventeen of 20 females were postmenopausal. Twelve patients had history of fractures. Only four patients were on treatment with bisphosphonate. All measured bone metabolites were in normal ranges, but U-calcium was in the lower ranges. According to DEXA, eight patients had osteopenia (T-value = -1.0 - -2.5) and three osteoporosis (T-value <---2.5), while six patients had BMD more than one standard deviation below the mean of age matched controls. CONCLUSION: Although the majority of patients with SSc have normal bone turnover and BMD, every fourth patient may have low BMD. No single pathogenic factor was observed, however, several individuals are in calcium saving stages reflected in low urinary calcium excretion. This may be result of defects in intestinal absorption of calcium due to gastrointestinal involvement of the disease. This study does not give opportunity to evaluate effects of treatment on BMD in this group of patients. Thus, individual evaluation concerning osteoporosis is recommended in patients with SSc. Bakgrunnur: Herslismein (Systemic Sclerosis) er sjaldgæfur fjölkerfasjúkdómur. Fjölmargir þættir í sjúkdómsbirtingu og meðferð sjúkdómsins geta valdið ótímabærri ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Smella ENVELOPE(29.443,29.443,69.896,69.896) |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
Icelandic |
topic |
Herslismein Beinþynning LBL12 Bone Density Bone Diseases Metabolic Calcium Densitometry X-Ray Iceland Osteoporosis Scleroderma Systemic |
spellingShingle |
Herslismein Beinþynning LBL12 Bone Density Bone Diseases Metabolic Calcium Densitometry X-Ray Iceland Osteoporosis Scleroderma Systemic Bjarki Þór Alexandersson Árni Jón Geirsson Ísleifur Ólafsson Leifur Franzson Gunnar Sigurðsson Björn Guðbjörnsson Beina- og kalkbúskapur sjúklinga með herslismein |
topic_facet |
Herslismein Beinþynning LBL12 Bone Density Bone Diseases Metabolic Calcium Densitometry X-Ray Iceland Osteoporosis Scleroderma Systemic |
description |
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open AIMS: To elucidate bone mineral density (BMD) and bone turnover in an un-selected group of patients with Systemic Sclerosis (SSc) in national based registry. MATERIAL AND METHODS: All patients who have been diagnosed with SSc in Iceland were invited to participate in the study. Participants underwent standardized interview and delivered urine and blood samples for measurements of various bone metabolites (e.g. PTH, osteocalcin, Cross Laps, PINP, IGF-1, Cystatin-C and 25-OH-vitamin-D), before they underwent measurement of BMD with DEXA (QDR 4500 Elite). RESULTS: Twenty-four individuals, 20 female and four male, of 29 diagnosed patients with SSc in Iceland accepted to participate in the study (83%). The mean age was 60 +/- 15 years. Seventeen of 20 females were postmenopausal. Twelve patients had history of fractures. Only four patients were on treatment with bisphosphonate. All measured bone metabolites were in normal ranges, but U-calcium was in the lower ranges. According to DEXA, eight patients had osteopenia (T-value = -1.0 - -2.5) and three osteoporosis (T-value <---2.5), while six patients had BMD more than one standard deviation below the mean of age matched controls. CONCLUSION: Although the majority of patients with SSc have normal bone turnover and BMD, every fourth patient may have low BMD. No single pathogenic factor was observed, however, several individuals are in calcium saving stages reflected in low urinary calcium excretion. This may be result of defects in intestinal absorption of calcium due to gastrointestinal involvement of the disease. This study does not give opportunity to evaluate effects of treatment on BMD in this group of patients. Thus, individual evaluation concerning osteoporosis is recommended in patients with SSc. Bakgrunnur: Herslismein (Systemic Sclerosis) er sjaldgæfur fjölkerfasjúkdómur. Fjölmargir þættir í sjúkdómsbirtingu og meðferð sjúkdómsins geta valdið ótímabærri ... |
format |
Article in Journal/Newspaper |
author |
Bjarki Þór Alexandersson Árni Jón Geirsson Ísleifur Ólafsson Leifur Franzson Gunnar Sigurðsson Björn Guðbjörnsson |
author_facet |
Bjarki Þór Alexandersson Árni Jón Geirsson Ísleifur Ólafsson Leifur Franzson Gunnar Sigurðsson Björn Guðbjörnsson |
author_sort |
Bjarki Þór Alexandersson |
title |
Beina- og kalkbúskapur sjúklinga með herslismein |
title_short |
Beina- og kalkbúskapur sjúklinga með herslismein |
title_full |
Beina- og kalkbúskapur sjúklinga með herslismein |
title_fullStr |
Beina- og kalkbúskapur sjúklinga með herslismein |
title_full_unstemmed |
Beina- og kalkbúskapur sjúklinga með herslismein |
title_sort |
beina- og kalkbúskapur sjúklinga með herslismein |
publisher |
Læknafélag Íslands, Læknafélag Reykjavíkur |
publishDate |
2007 |
url |
http://hdl.handle.net/2336/13864 |
long_lat |
ENVELOPE(29.443,29.443,69.896,69.896) |
geographic |
Smella |
geographic_facet |
Smella |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.laeknabladid.is Læknablaðið 2007, 93(7-8):535-41 0023-7213 17823496 http://hdl.handle.net/2336/13864 Læknablaðið |
_version_ |
1766037804905660416 |