Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma.
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field PURPOSE: Lung cancer is the leading cause of cancer related mortality in the world. Bronchioloalveolar carcinoma (BAC) is a subset of NSCLC that has recently gained attention because of dist...
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/13085 2023-05-15T16:52:20+02:00 Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma. Tsurutani, Junji Steinberg, Seth M Ballas, Marc Robertson, Matthew LoPiccolo, Jaclyn Soda, Hiroshi Kohno, Shigeru Egilsson, Valgardur Dennis, Phillip A 2007-08-02 YES http://hdl.handle.net/2336/13085 https://doi.org/10.1016/j.lungcan.2006.09.026 en eng Elsevier Scientific Publishers http://www.sciencedirect.com/science/article/B6T9C-4MBC4SK-1/2/eed1c13e0b920b27da6c966a698b0e10 Lung Cancer 2007, 55(1):115-21 0169-5002 17097759 doi:10.1016/j.lungcan.2006.09.026 PTT12 http://hdl.handle.net/2336/13085 PubMed - in process Article 2007 ftlandspitaliuni https://doi.org/10.1016/j.lungcan.2006.09.026 2022-05-29T08:21:00Z To access publisher full text version of this article. Please click on the hyperlink in Additional Link field PURPOSE: Lung cancer is the leading cause of cancer related mortality in the world. Bronchioloalveolar carcinoma (BAC) is a subset of NSCLC that has recently gained attention because of distinct biological and clinical features, increased incidence, and enhanced responsiveness to new therapies such as epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). However, prognostic features for BAC have not been well defined. Because activation of Akt is highly prevalent and a poor prognostic factor for other types of NSCLC, we assessed the prognostic significance of clinical features and Akt activation in patients with BAC. METHODS: Forty-six cases of BAC in Iceland were classified according to WHO 1999 criteria. Akt activation was assessed using two phospho-specific antibodies against Akt (S473 and T308) in immunohistochemical (IHC) analysis. Associations between ordered Akt levels and other dichotomous parameters were evaluated using an exact Cochran-Armitage test for trend. Survival was analyzed by the Kaplan-Meier method and log-rank test, with hazard ratios (HR) determined by Cox proportional hazard models. The Cox model was also used to assess the joint effect of multiple factors on survival when they are considered simultaneously. RESULTS: Age and histology (mucinous versus non-mucinous) were not associated with survival. Activation of Akt was highly prevalent in BAC, with only 2 out of 46 patients exhibiting negative staining with either antibody. Moderate to high Akt activation was observed in 63% of cases and was associated with non-mucinous histology. Akt activation was not associated with differences in survival or smoking status. In contrast, Cox model analysis revealed that male gender (HR 2.24, 95% CI, 1.07-4.71, p=0.032), advanced stage (III or IV) (HR 2.17, 95% CI, 1.004-4.71, p=0.049) and smoking status (HR 6.89, 95% CI, 1.49-31.88, p=0.013) were associated with a worse ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Meier ENVELOPE(-45.900,-45.900,-60.633,-60.633) Armitage ENVELOPE(166.667,166.667,-77.850,-77.850) Lung Cancer 55 1 115 121 |
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Hirsla - Landspítali University Hospital research archive |
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PubMed - in process Tsurutani, Junji Steinberg, Seth M Ballas, Marc Robertson, Matthew LoPiccolo, Jaclyn Soda, Hiroshi Kohno, Shigeru Egilsson, Valgardur Dennis, Phillip A Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma. |
topic_facet |
PubMed - in process |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field PURPOSE: Lung cancer is the leading cause of cancer related mortality in the world. Bronchioloalveolar carcinoma (BAC) is a subset of NSCLC that has recently gained attention because of distinct biological and clinical features, increased incidence, and enhanced responsiveness to new therapies such as epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). However, prognostic features for BAC have not been well defined. Because activation of Akt is highly prevalent and a poor prognostic factor for other types of NSCLC, we assessed the prognostic significance of clinical features and Akt activation in patients with BAC. METHODS: Forty-six cases of BAC in Iceland were classified according to WHO 1999 criteria. Akt activation was assessed using two phospho-specific antibodies against Akt (S473 and T308) in immunohistochemical (IHC) analysis. Associations between ordered Akt levels and other dichotomous parameters were evaluated using an exact Cochran-Armitage test for trend. Survival was analyzed by the Kaplan-Meier method and log-rank test, with hazard ratios (HR) determined by Cox proportional hazard models. The Cox model was also used to assess the joint effect of multiple factors on survival when they are considered simultaneously. RESULTS: Age and histology (mucinous versus non-mucinous) were not associated with survival. Activation of Akt was highly prevalent in BAC, with only 2 out of 46 patients exhibiting negative staining with either antibody. Moderate to high Akt activation was observed in 63% of cases and was associated with non-mucinous histology. Akt activation was not associated with differences in survival or smoking status. In contrast, Cox model analysis revealed that male gender (HR 2.24, 95% CI, 1.07-4.71, p=0.032), advanced stage (III or IV) (HR 2.17, 95% CI, 1.004-4.71, p=0.049) and smoking status (HR 6.89, 95% CI, 1.49-31.88, p=0.013) were associated with a worse ... |
format |
Article in Journal/Newspaper |
author |
Tsurutani, Junji Steinberg, Seth M Ballas, Marc Robertson, Matthew LoPiccolo, Jaclyn Soda, Hiroshi Kohno, Shigeru Egilsson, Valgardur Dennis, Phillip A |
author_facet |
Tsurutani, Junji Steinberg, Seth M Ballas, Marc Robertson, Matthew LoPiccolo, Jaclyn Soda, Hiroshi Kohno, Shigeru Egilsson, Valgardur Dennis, Phillip A |
author_sort |
Tsurutani, Junji |
title |
Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma. |
title_short |
Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma. |
title_full |
Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma. |
title_fullStr |
Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma. |
title_full_unstemmed |
Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma. |
title_sort |
prognostic significance of clinical factors and akt activation in patients with bronchioloalveolar carcinoma. |
publisher |
Elsevier Scientific Publishers |
publishDate |
2007 |
url |
http://hdl.handle.net/2336/13085 https://doi.org/10.1016/j.lungcan.2006.09.026 |
long_lat |
ENVELOPE(-45.900,-45.900,-60.633,-60.633) ENVELOPE(166.667,166.667,-77.850,-77.850) |
geographic |
Meier Armitage |
geographic_facet |
Meier Armitage |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.sciencedirect.com/science/article/B6T9C-4MBC4SK-1/2/eed1c13e0b920b27da6c966a698b0e10 Lung Cancer 2007, 55(1):115-21 0169-5002 17097759 doi:10.1016/j.lungcan.2006.09.026 PTT12 http://hdl.handle.net/2336/13085 |
op_doi |
https://doi.org/10.1016/j.lungcan.2006.09.026 |
container_title |
Lung Cancer |
container_volume |
55 |
container_issue |
1 |
container_start_page |
115 |
op_container_end_page |
121 |
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1766042470915768320 |