Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

• Published in: Nature Genetics
• Main Authors: Gretarsdottir, Solveig, Baas, Annette F, Thorleifsson, Gudmar, Holm, Hilma, den Heijer, Martin, de Vries, Jean-Paul P M, Kranendonk, Steef E, Zeebregts, Clark J A M, van Sterkenburg, Steven M, Geelkerken, Robert H, van Rij, Andre M, Williams, Michael J A, Boll, Albert P M, Kostic, Jelena P, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Walters, G Bragi, Masson, Gisli, Sulem, Patrick, Saemundsdottir, Jona, Mouy, Magali, Magnusson, Kristinn P, Tromp, Gerard, Elmore, James R, Sakalihasan, Natzi, Limet, Raymond, Defraigne, Jean-Olivier, Ferrell, Robert E, Ronkainen, Antti, Ruigrok, Ynte M, Wijmenga, Cisca, Grobbee, Diederick E, Shah, Svati H, Granger, Christopher B, Quyyumi, Arshed A, Vaccarino, Viola, Patel, Riyaz S, Zafari, A Maziar, Levey, Allan I, Austin, Harland, Girelli, Domenico, Pignatti, Pier Franco, Olivieri, Oliviero, Martinelli, Nicola, Malerba, Giovanni, Trabetti, Elisabetta, Becker, Lewis C, Becker, Diane M, Reilly, Muredach P, Rader, Daniel J
• Other Authors: Population Genomics, deCODE Genetics, Reykjavik, Iceland. [e-mail]
• Format: Article in Journal/Newspaper
• Language: English
• Published: Nature Pub. Co. 2011
• Subjects: Alleles; Aortic Aneurysm; Abdominal; Base Sequence; Disease Susceptibility; Genome-Wide Association Study; Humans; Hypertension; Iceland; Myocardial Infarction; Netherlands; Odds Ratio; Risk Factors; ras GTPase-Activating Proteins
• Online Access: http://hdl.handle.net/2336/128783; https://doi.org/10.1038/ng.622

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.