The acute phase response of Atlantic cod (Gadus morhua): Humoral and cellular response.

• Published in: Fish & Shellfish Immunology
• Main Authors: Magnadottir, Bergljot, Audunsdottir, Sigridur S, Bragason, Birkir Th, Gisladottir, Berglind, Jonsson, Zophonias O, Gudmundsdottir, Sigridur
• Other Authors: Institute for Experimental Pathology, University of Iceland, Keldur v. Vesturlandsveg, 112 Reykjavik, Iceland.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Academic Press 2011
• Subjects: PubMed in process; atlantic cod; Gadus morhua
• Online Access: http://hdl.handle.net/2336/128675; https://doi.org/10.1016/j.fsi.2011.02.010

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Intra-muscular injection of turpentine oil was used to induce acute phase response (APR) in Atlantic cod (Gadus morhua L.). The effects on the serum cortisol, total protein, IgM and pentraxin concentration were examined as well as the effects on natural antibody, anti-trypsin and leukocyte respiratory burst activity. The turpentine injection resulted in a 26 fold increase in the cortisol level after 72 h. Slightly reduced serum protein level in both groups was attributed to the restricted feeding during the experimental period. The IgM serum concentration was significantly reduced after 168 h in the turpentine treated fish while the natural antibody activity was not affected. The anti-trypsin activity was initially suppressed but recovered to normal levels at the end of the experiment. The turpentine injection had little effect on the serum level of the pentraxins, CRP-PI and CRP-PII. The respiratory burst activity was significantly suppressed after 72 h. It is concluded that 1) cod shows a relatively slow humoral and cellular response to APR induction, 2) the increase in serum cortisol level may be the key modulator of the mainly suppressive effects on the immune parameters and 3) pentraxins are not typical acute phase proteins in cod.