Relationships between vitamin D status and cardio-metabolic risk factors in young European adults
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Background/Aims: To explore associations between vitamin D and cardiovascular disease risk factors in young European adults. Methods: This was a cross-sectional analysis of serum 25-hydroxy...
Published in: | Annals of Nutrition and Metabolism |
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Online Access: | http://hdl.handle.net/2336/128052 https://doi.org/10.1159/000324600 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/128052 2023-05-15T16:49:39+02:00 Relationships between vitamin D status and cardio-metabolic risk factors in young European adults Muldowney, S Lucey, A J Paschos, G Martinez, J A Bandarra, N Thorsdottir, I Cashman, K D Kiely, M Vitamin D Research Group, School of Food and Nutritional Sciences, University College Cork, Cork, Ireland. 2011-04-13 http://hdl.handle.net/2336/128052 https://doi.org/10.1159/000324600 ENG n/a eng Krager http://dx.doi.org/10.1159/000324600 Ann Nutr Metab. 2011, 58(2):85-93 1421-9697 21474925 doi:10.1159/000324600 http://hdl.handle.net/2336/128052 Annals of nutrition & metabolism Cardiovascular Diseases Vitamin D Pubmed in process Article 2011 ftlandspitaliuni https://doi.org/10.1159/000324600 2022-05-29T08:21:45Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Background/Aims: To explore associations between vitamin D and cardiovascular disease risk factors in young European adults. Methods: This was a cross-sectional analysis of serum 25-hydroxyvitamin D [s25(OH)D], intact parathyroid hormone (iPTH) and biomarkers of cardiovascular disease risk in 195 healthy 20- to 40-year-olds (109 women) with a BMI between 27.5 and 32.5 from Iceland (64°N; n = 82), Ireland (51°N; n = 37) and Spain (42°N; n = 76) during mid-late winter. Results: The median s25(OH)D was 52.8 nmol/l (IQR 38.1-69.9) or 21.1 ng/ml (IQR 15.2-28.0) with a latitude-dependent gradient (p ≤ 0.0001): Iceland, 41.7 nmol/l (IQR 32.7-54.2) or 16.7 ng/ml (IQR 13.1-21.7); Ireland, 52.9 nmol/l (IQR 35.3-68.6) or 21.2 ng/ml (IQR 14.1-27.4), and Spain, 67.1 nmol/l (IQR 47.1-87.1) or 26.8 ng/ml (IQR 18.8-34.8). Eleven percent of Icelandic participants had s25(OH)D concentrations <25 nmol/l (10 ng/ml) and 66% of Icelandic, 43% of Irish, and 30% of Spanish volunteers had concentrations <50 nmol/l (20 ng/ml), respectively. Overall, 17% met 3 or more of the NCEP/ATP III criteria for cardio-metabolic syndrome (MetS). Participants in the lowest third of s25(OH)D [≤42.5 nmol/l (17 ng/ml)] were more likely to have MetS (OR 2.49, p = 0.045) and elevated TAG (OR 3.46, p = 0.019). Individuals with iPTH concentrations in the lowest third [2.34 pmol/l (22.2 pg/ml)] were more likely to have elevated fasting TAG (OR 4.17, p = 0.039), insulin (OR 3.15, p = 0.029) and HOMA-IR (OR 2.15, p = 0.031), and they were less likely to have elevated IL-6 (OR 0.24, p = 0.003). Conclusion: There were interactions between s25(OH)D, iPTH and cardio-metabolic risk factors which, given the increasing prevalence of overweight and obesity and a low vitamin D status among adults, require randomised controlled vitamin D intervention studies in overweight persons. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Annals of Nutrition and Metabolism 58 2 85 93 |
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Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Cardiovascular Diseases Vitamin D Pubmed in process |
spellingShingle |
Cardiovascular Diseases Vitamin D Pubmed in process Muldowney, S Lucey, A J Paschos, G Martinez, J A Bandarra, N Thorsdottir, I Cashman, K D Kiely, M Relationships between vitamin D status and cardio-metabolic risk factors in young European adults |
topic_facet |
Cardiovascular Diseases Vitamin D Pubmed in process |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Background/Aims: To explore associations between vitamin D and cardiovascular disease risk factors in young European adults. Methods: This was a cross-sectional analysis of serum 25-hydroxyvitamin D [s25(OH)D], intact parathyroid hormone (iPTH) and biomarkers of cardiovascular disease risk in 195 healthy 20- to 40-year-olds (109 women) with a BMI between 27.5 and 32.5 from Iceland (64°N; n = 82), Ireland (51°N; n = 37) and Spain (42°N; n = 76) during mid-late winter. Results: The median s25(OH)D was 52.8 nmol/l (IQR 38.1-69.9) or 21.1 ng/ml (IQR 15.2-28.0) with a latitude-dependent gradient (p ≤ 0.0001): Iceland, 41.7 nmol/l (IQR 32.7-54.2) or 16.7 ng/ml (IQR 13.1-21.7); Ireland, 52.9 nmol/l (IQR 35.3-68.6) or 21.2 ng/ml (IQR 14.1-27.4), and Spain, 67.1 nmol/l (IQR 47.1-87.1) or 26.8 ng/ml (IQR 18.8-34.8). Eleven percent of Icelandic participants had s25(OH)D concentrations <25 nmol/l (10 ng/ml) and 66% of Icelandic, 43% of Irish, and 30% of Spanish volunteers had concentrations <50 nmol/l (20 ng/ml), respectively. Overall, 17% met 3 or more of the NCEP/ATP III criteria for cardio-metabolic syndrome (MetS). Participants in the lowest third of s25(OH)D [≤42.5 nmol/l (17 ng/ml)] were more likely to have MetS (OR 2.49, p = 0.045) and elevated TAG (OR 3.46, p = 0.019). Individuals with iPTH concentrations in the lowest third [2.34 pmol/l (22.2 pg/ml)] were more likely to have elevated fasting TAG (OR 4.17, p = 0.039), insulin (OR 3.15, p = 0.029) and HOMA-IR (OR 2.15, p = 0.031), and they were less likely to have elevated IL-6 (OR 0.24, p = 0.003). Conclusion: There were interactions between s25(OH)D, iPTH and cardio-metabolic risk factors which, given the increasing prevalence of overweight and obesity and a low vitamin D status among adults, require randomised controlled vitamin D intervention studies in overweight persons. |
author2 |
Vitamin D Research Group, School of Food and Nutritional Sciences, University College Cork, Cork, Ireland. |
format |
Article in Journal/Newspaper |
author |
Muldowney, S Lucey, A J Paschos, G Martinez, J A Bandarra, N Thorsdottir, I Cashman, K D Kiely, M |
author_facet |
Muldowney, S Lucey, A J Paschos, G Martinez, J A Bandarra, N Thorsdottir, I Cashman, K D Kiely, M |
author_sort |
Muldowney, S |
title |
Relationships between vitamin D status and cardio-metabolic risk factors in young European adults |
title_short |
Relationships between vitamin D status and cardio-metabolic risk factors in young European adults |
title_full |
Relationships between vitamin D status and cardio-metabolic risk factors in young European adults |
title_fullStr |
Relationships between vitamin D status and cardio-metabolic risk factors in young European adults |
title_full_unstemmed |
Relationships between vitamin D status and cardio-metabolic risk factors in young European adults |
title_sort |
relationships between vitamin d status and cardio-metabolic risk factors in young european adults |
publisher |
Krager |
publishDate |
2011 |
url |
http://hdl.handle.net/2336/128052 https://doi.org/10.1159/000324600 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1159/000324600 Ann Nutr Metab. 2011, 58(2):85-93 1421-9697 21474925 doi:10.1159/000324600 http://hdl.handle.net/2336/128052 Annals of nutrition & metabolism |
op_doi |
https://doi.org/10.1159/000324600 |
container_title |
Annals of Nutrition and Metabolism |
container_volume |
58 |
container_issue |
2 |
container_start_page |
85 |
op_container_end_page |
93 |
_version_ |
1766039809188429824 |