Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory dis...
Published in: | Nature Genetics |
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Online Access: | http://hdl.handle.net/2336/127707 https://doi.org/10.1038/ng.323 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/127707 2023-05-15T16:51:12+02:00 Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction Gudbjartsson, Daniel F Bjornsdottir, Unnur S Halapi, Eva Helgadottir, Anna Sulem, Patrick Jonsdottir, Gudrun M Thorleifsson, Gudmar Helgadottir, Hafdis Steinthorsdottir, Valgerdur Stefansson, Hreinn Williams, Carolyn Hui, Jennie Beilby, John Warrington, Nicole M James, Alan Palmer, Lyle J Koppelman, Gerard H Heinzmann, Andrea Krueger, Marcus Boezen, H Marike Wheatley, Amanda Altmuller, Janine Shin, Hyoung Doo Uh, Soo-Taek Cheong, Hyun Sub Jonsdottir, Brynja Gislason, David Park, Choon-Sik Rasmussen, Linda M Porsbjerg, Celeste Hansen, Jakob W Backer, Vibeke Werge, Thomas Janson, Christer Jönsson, Ulla-Britt Ng, Maggie C Y Chan, Juliana So, Wing Yee Ma, Ronald Shah, Svati H Granger, Christopher B Quyyumi, Arshed A Levey, Allan I Vaccarino, Viola Reilly, Muredach P Rader, Daniel J Williams, Michael J A van Rij, Andre M Jones, Gregory T Trabetti, Elisabetta deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland. daniel.gudbjartsson@decode.is 2011-04-07 http://hdl.handle.net/2336/127707 https://doi.org/10.1038/ng.323 en eng Nature Pub. Co. http://dx.doi.org/10.1038/ng.323 Nat. Genet. 2009, 41 (3):342-7 1546-1718 19198610 doi:10.1038/ng.323 http://hdl.handle.net/2336/127707 Nature genetics Adaptor Proteins Vesicular Transport Algorithms Asthma Case-Control Studies Eosinophils Eye Proteins Genes myb Genetic Predisposition to Disease Genome-Wide Association Study Humans Iceland Interleukins Leukocyte Count Myocardial Infarction Polymorphism Single Nucleotide Proteins Receptors Cell Surface Article 2011 ftlandspitaliuni https://doi.org/10.1038/ng.323 2022-05-29T08:21:45Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls). Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Nature Genetics 41 3 342 347 |
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Hirsla - Landspítali University Hospital research archive |
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ftlandspitaliuni |
language |
English |
topic |
Adaptor Proteins Vesicular Transport Algorithms Asthma Case-Control Studies Eosinophils Eye Proteins Genes myb Genetic Predisposition to Disease Genome-Wide Association Study Humans Iceland Interleukins Leukocyte Count Myocardial Infarction Polymorphism Single Nucleotide Proteins Receptors Cell Surface |
spellingShingle |
Adaptor Proteins Vesicular Transport Algorithms Asthma Case-Control Studies Eosinophils Eye Proteins Genes myb Genetic Predisposition to Disease Genome-Wide Association Study Humans Iceland Interleukins Leukocyte Count Myocardial Infarction Polymorphism Single Nucleotide Proteins Receptors Cell Surface Gudbjartsson, Daniel F Bjornsdottir, Unnur S Halapi, Eva Helgadottir, Anna Sulem, Patrick Jonsdottir, Gudrun M Thorleifsson, Gudmar Helgadottir, Hafdis Steinthorsdottir, Valgerdur Stefansson, Hreinn Williams, Carolyn Hui, Jennie Beilby, John Warrington, Nicole M James, Alan Palmer, Lyle J Koppelman, Gerard H Heinzmann, Andrea Krueger, Marcus Boezen, H Marike Wheatley, Amanda Altmuller, Janine Shin, Hyoung Doo Uh, Soo-Taek Cheong, Hyun Sub Jonsdottir, Brynja Gislason, David Park, Choon-Sik Rasmussen, Linda M Porsbjerg, Celeste Hansen, Jakob W Backer, Vibeke Werge, Thomas Janson, Christer Jönsson, Ulla-Britt Ng, Maggie C Y Chan, Juliana So, Wing Yee Ma, Ronald Shah, Svati H Granger, Christopher B Quyyumi, Arshed A Levey, Allan I Vaccarino, Viola Reilly, Muredach P Rader, Daniel J Williams, Michael J A van Rij, Andre M Jones, Gregory T Trabetti, Elisabetta Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction |
topic_facet |
Adaptor Proteins Vesicular Transport Algorithms Asthma Case-Control Studies Eosinophils Eye Proteins Genes myb Genetic Predisposition to Disease Genome-Wide Association Study Humans Iceland Interleukins Leukocyte Count Myocardial Infarction Polymorphism Single Nucleotide Proteins Receptors Cell Surface |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls). |
author2 |
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland. daniel.gudbjartsson@decode.is |
format |
Article in Journal/Newspaper |
author |
Gudbjartsson, Daniel F Bjornsdottir, Unnur S Halapi, Eva Helgadottir, Anna Sulem, Patrick Jonsdottir, Gudrun M Thorleifsson, Gudmar Helgadottir, Hafdis Steinthorsdottir, Valgerdur Stefansson, Hreinn Williams, Carolyn Hui, Jennie Beilby, John Warrington, Nicole M James, Alan Palmer, Lyle J Koppelman, Gerard H Heinzmann, Andrea Krueger, Marcus Boezen, H Marike Wheatley, Amanda Altmuller, Janine Shin, Hyoung Doo Uh, Soo-Taek Cheong, Hyun Sub Jonsdottir, Brynja Gislason, David Park, Choon-Sik Rasmussen, Linda M Porsbjerg, Celeste Hansen, Jakob W Backer, Vibeke Werge, Thomas Janson, Christer Jönsson, Ulla-Britt Ng, Maggie C Y Chan, Juliana So, Wing Yee Ma, Ronald Shah, Svati H Granger, Christopher B Quyyumi, Arshed A Levey, Allan I Vaccarino, Viola Reilly, Muredach P Rader, Daniel J Williams, Michael J A van Rij, Andre M Jones, Gregory T Trabetti, Elisabetta |
author_facet |
Gudbjartsson, Daniel F Bjornsdottir, Unnur S Halapi, Eva Helgadottir, Anna Sulem, Patrick Jonsdottir, Gudrun M Thorleifsson, Gudmar Helgadottir, Hafdis Steinthorsdottir, Valgerdur Stefansson, Hreinn Williams, Carolyn Hui, Jennie Beilby, John Warrington, Nicole M James, Alan Palmer, Lyle J Koppelman, Gerard H Heinzmann, Andrea Krueger, Marcus Boezen, H Marike Wheatley, Amanda Altmuller, Janine Shin, Hyoung Doo Uh, Soo-Taek Cheong, Hyun Sub Jonsdottir, Brynja Gislason, David Park, Choon-Sik Rasmussen, Linda M Porsbjerg, Celeste Hansen, Jakob W Backer, Vibeke Werge, Thomas Janson, Christer Jönsson, Ulla-Britt Ng, Maggie C Y Chan, Juliana So, Wing Yee Ma, Ronald Shah, Svati H Granger, Christopher B Quyyumi, Arshed A Levey, Allan I Vaccarino, Viola Reilly, Muredach P Rader, Daniel J Williams, Michael J A van Rij, Andre M Jones, Gregory T Trabetti, Elisabetta |
author_sort |
Gudbjartsson, Daniel F |
title |
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction |
title_short |
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction |
title_full |
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction |
title_fullStr |
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction |
title_full_unstemmed |
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction |
title_sort |
sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction |
publisher |
Nature Pub. Co. |
publishDate |
2011 |
url |
http://hdl.handle.net/2336/127707 https://doi.org/10.1038/ng.323 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1038/ng.323 Nat. Genet. 2009, 41 (3):342-7 1546-1718 19198610 doi:10.1038/ng.323 http://hdl.handle.net/2336/127707 Nature genetics |
op_doi |
https://doi.org/10.1038/ng.323 |
container_title |
Nature Genetics |
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41 |
container_issue |
3 |
container_start_page |
342 |
op_container_end_page |
347 |
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1766041313461927936 |