High white blood cell count at diagnosis of childhood acute lymphoblastic leukaemia: biological background and prognostic impact. Results from the NOPHO ALL-92 and ALL-2000 studies
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Prognostic impact of peripheral blood white blood cell count (WBC) at the diagnosis of childhood acute lymphoblastic leukaemia (ALL) was evaluated in a population-based consecutive series o...
Published in: | European Journal of Haematology |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Munksgaard
2011
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Online Access: | http://hdl.handle.net/2336/125685 https://doi.org/10.1111/j.1600-0609.2010.01522.x |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/125685 2023-05-15T16:49:08+02:00 High white blood cell count at diagnosis of childhood acute lymphoblastic leukaemia: biological background and prognostic impact. Results from the NOPHO ALL-92 and ALL-2000 studies Vaitkevičienė, Goda Forestier, Erik Hellebostad, Marit Heyman, Mats Jonsson, Olafur G Lähteenmäki, Päivi M Rosthoej, Susanne Söderhäll, Stefan Schmiegelow, Kjeld Centre for Paediatric Oncology and Haematology, University Childrens Hospital, Vilnius, Lithuania. 2011-03-25 http://hdl.handle.net/2336/125685 https://doi.org/10.1111/j.1600-0609.2010.01522.x en eng Munksgaard http://dx.doi.org/10.1111/j.1600-0609.2010.01522.x Eur. J. Haematol. 2011, 86(1):38-46 1600-0609 21077959 doi:10.1111/j.1600-0609.2010.01522.x http://hdl.handle.net/2336/125685 European journal of haematology Adolescent Child Preschool Female Finland Humans Iceland Infant Leukocyte Count Lymphocytes Male Neoplasm Residual Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis Scandinavia Survival Analysis Article 2011 ftlandspitaliuni https://doi.org/10.1111/j.1600-0609.2010.01522.x 2022-05-29T08:21:43Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Prognostic impact of peripheral blood white blood cell count (WBC) at the diagnosis of childhood acute lymphoblastic leukaemia (ALL) was evaluated in a population-based consecutive series of 2666 children aged 1-15 treated for ALL between 1992 and 2008 in the five Nordic countries (Denmark, Finland, Iceland, Norway and Sweden). Ten-year event-free (pEFS(10 y)) survival and overall (pOS(10 y)) survival were 0.75 ± 0.01 and 0.85 ± 0.01, respectively. Although treatment intensity was determined by WBC, non-remission and relapsed patients still had significantly higher WBC than those in remission for B-cell precursor (BCP) (median WBC: 24.8 vs. 14.0 vs. 8.3 × 10(9) /L, P < 0.001), but not for T-lineage (T-ALL) (median WBC: 127.8 vs. 113.0 vs. 86.8 × 10(9) /L, P = 0.22). pEFS was inversely related to WBC for BCP (P < 0.001), but not for T-ALL. WBC was not associated with risk of event for BCP or T-ALL for patients with minimal residual disease at the end of induction (MRD(d29) ) <10(-3). In contrast, for MRD(d29) ≥ 10(-3) and <5% leukaemic blasts in bone marrow at day 29, the pEFS(5 y) for WBC < 100.0 (N = 152) vs. ≥ 100.0 (N = 19) was 0.76 vs. 0.50 (P = 0.001). That was the case both for BCP (pEFS(5 y) 0.76 vs. 0.58) and for T-ALL (pEFS(5 y) 0.71 vs. 0.38). Whether the inferior EFS for the subset of patients with high WBC and slow initial response to treatment reflects rare or overlooked cytogenetic aberrations as well as the factors that determine WBC levels at diagnosis awaits exploration. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Norway European Journal of Haematology 86 1 38 46 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adolescent Child Preschool Female Finland Humans Iceland Infant Leukocyte Count Lymphocytes Male Neoplasm Residual Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis Scandinavia Survival Analysis |
spellingShingle |
Adolescent Child Preschool Female Finland Humans Iceland Infant Leukocyte Count Lymphocytes Male Neoplasm Residual Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis Scandinavia Survival Analysis Vaitkevičienė, Goda Forestier, Erik Hellebostad, Marit Heyman, Mats Jonsson, Olafur G Lähteenmäki, Päivi M Rosthoej, Susanne Söderhäll, Stefan Schmiegelow, Kjeld High white blood cell count at diagnosis of childhood acute lymphoblastic leukaemia: biological background and prognostic impact. Results from the NOPHO ALL-92 and ALL-2000 studies |
topic_facet |
Adolescent Child Preschool Female Finland Humans Iceland Infant Leukocyte Count Lymphocytes Male Neoplasm Residual Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis Scandinavia Survival Analysis |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Prognostic impact of peripheral blood white blood cell count (WBC) at the diagnosis of childhood acute lymphoblastic leukaemia (ALL) was evaluated in a population-based consecutive series of 2666 children aged 1-15 treated for ALL between 1992 and 2008 in the five Nordic countries (Denmark, Finland, Iceland, Norway and Sweden). Ten-year event-free (pEFS(10 y)) survival and overall (pOS(10 y)) survival were 0.75 ± 0.01 and 0.85 ± 0.01, respectively. Although treatment intensity was determined by WBC, non-remission and relapsed patients still had significantly higher WBC than those in remission for B-cell precursor (BCP) (median WBC: 24.8 vs. 14.0 vs. 8.3 × 10(9) /L, P < 0.001), but not for T-lineage (T-ALL) (median WBC: 127.8 vs. 113.0 vs. 86.8 × 10(9) /L, P = 0.22). pEFS was inversely related to WBC for BCP (P < 0.001), but not for T-ALL. WBC was not associated with risk of event for BCP or T-ALL for patients with minimal residual disease at the end of induction (MRD(d29) ) <10(-3). In contrast, for MRD(d29) ≥ 10(-3) and <5% leukaemic blasts in bone marrow at day 29, the pEFS(5 y) for WBC < 100.0 (N = 152) vs. ≥ 100.0 (N = 19) was 0.76 vs. 0.50 (P = 0.001). That was the case both for BCP (pEFS(5 y) 0.76 vs. 0.58) and for T-ALL (pEFS(5 y) 0.71 vs. 0.38). Whether the inferior EFS for the subset of patients with high WBC and slow initial response to treatment reflects rare or overlooked cytogenetic aberrations as well as the factors that determine WBC levels at diagnosis awaits exploration. |
author2 |
Centre for Paediatric Oncology and Haematology, University Childrens Hospital, Vilnius, Lithuania. |
format |
Article in Journal/Newspaper |
author |
Vaitkevičienė, Goda Forestier, Erik Hellebostad, Marit Heyman, Mats Jonsson, Olafur G Lähteenmäki, Päivi M Rosthoej, Susanne Söderhäll, Stefan Schmiegelow, Kjeld |
author_facet |
Vaitkevičienė, Goda Forestier, Erik Hellebostad, Marit Heyman, Mats Jonsson, Olafur G Lähteenmäki, Päivi M Rosthoej, Susanne Söderhäll, Stefan Schmiegelow, Kjeld |
author_sort |
Vaitkevičienė, Goda |
title |
High white blood cell count at diagnosis of childhood acute lymphoblastic leukaemia: biological background and prognostic impact. Results from the NOPHO ALL-92 and ALL-2000 studies |
title_short |
High white blood cell count at diagnosis of childhood acute lymphoblastic leukaemia: biological background and prognostic impact. Results from the NOPHO ALL-92 and ALL-2000 studies |
title_full |
High white blood cell count at diagnosis of childhood acute lymphoblastic leukaemia: biological background and prognostic impact. Results from the NOPHO ALL-92 and ALL-2000 studies |
title_fullStr |
High white blood cell count at diagnosis of childhood acute lymphoblastic leukaemia: biological background and prognostic impact. Results from the NOPHO ALL-92 and ALL-2000 studies |
title_full_unstemmed |
High white blood cell count at diagnosis of childhood acute lymphoblastic leukaemia: biological background and prognostic impact. Results from the NOPHO ALL-92 and ALL-2000 studies |
title_sort |
high white blood cell count at diagnosis of childhood acute lymphoblastic leukaemia: biological background and prognostic impact. results from the nopho all-92 and all-2000 studies |
publisher |
Munksgaard |
publishDate |
2011 |
url |
http://hdl.handle.net/2336/125685 https://doi.org/10.1111/j.1600-0609.2010.01522.x |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1111/j.1600-0609.2010.01522.x Eur. J. Haematol. 2011, 86(1):38-46 1600-0609 21077959 doi:10.1111/j.1600-0609.2010.01522.x http://hdl.handle.net/2336/125685 European journal of haematology |
op_doi |
https://doi.org/10.1111/j.1600-0609.2010.01522.x |
container_title |
European Journal of Haematology |
container_volume |
86 |
container_issue |
1 |
container_start_page |
38 |
op_container_end_page |
46 |
_version_ |
1766039208499085312 |