Decreasing case fatality in myocardial infarction is explained by improved medical treatment
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Objective Treatment of ST-elevation myocardial infarction (STEMI) has changed signifi cantly over the past two decades. We investigated the eff ect of these changes on one-year mortality. M...
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2011
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Online Access: | http://hdl.handle.net/2336/125248 https://doi.org/10.2143/AC.66.1.2064965 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/125248 2023-05-15T16:50:41+02:00 Decreasing case fatality in myocardial infarction is explained by improved medical treatment Andersen, K Johannesdottir, B K Kristjansson, J M Gudnason, T Landspitali University Hospital, Reykjavik, Iceland 2011-03-21 http://hdl.handle.net/2336/125248 https://doi.org/10.2143/AC.66.1.2064965 en eng Association Royale des Societes Scientifiques Medicales Belges/Koninklijke Vereniging van de Belgische Medische Wetenschappelijke Genootschappen http://poj.peeters-leuven.be/content.php?url=article&id=2064965 Acta Cardiologica. 2011, 66(1):39-46 0001-5385 doi:10.2143/AC.66.1.2064965 http://hdl.handle.net/2336/125248 Acta Cardiologica Myocardial Infarction Cardiovascular Diseases/epidemiology Treatment Outcome Prognosis Article 2011 ftlandspitaliuni https://doi.org/10.2143/AC.66.1.2064965 2022-05-29T08:21:43Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Objective Treatment of ST-elevation myocardial infarction (STEMI) has changed signifi cantly over the past two decades. We investigated the eff ect of these changes on one-year mortality. Methods and results All hospital admissions for STEMI in Reykjavik, Iceland, during the calendar years of 1986, 1996 and 2006 were studied. One-year mortality was related to changes in the use of reperfusion strategies and medication at hospital discharge. One-year mortality decreased from 26.3% in 1986 and 19.7% in 1996 to 12.9% in 2006 (P = 0.001). Cox proportional hazard analysis showed that aspirin (HR 0.29), the use of reperfusion therapy (HR 0.51) and beta-blockers at hospital discharge (HR 0.53) were the strongest factors to explain the mortality reduction while the use of diuretics (HR 1.42) and age (HR 1.06) were related to increased one-year mortality. Conclusions The reduction in one-year mortality after myocardial infarction during the last two decades is explained by improved medical management with aspirin, beta-blockers and aggressive reperfusion therapy. Diuretic therapy, refl ecting congestive heart failure, and increased age have negative eff ects on survival. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Myocardial Infarction Cardiovascular Diseases/epidemiology Treatment Outcome Prognosis |
spellingShingle |
Myocardial Infarction Cardiovascular Diseases/epidemiology Treatment Outcome Prognosis Andersen, K Johannesdottir, B K Kristjansson, J M Gudnason, T Decreasing case fatality in myocardial infarction is explained by improved medical treatment |
topic_facet |
Myocardial Infarction Cardiovascular Diseases/epidemiology Treatment Outcome Prognosis |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Objective Treatment of ST-elevation myocardial infarction (STEMI) has changed signifi cantly over the past two decades. We investigated the eff ect of these changes on one-year mortality. Methods and results All hospital admissions for STEMI in Reykjavik, Iceland, during the calendar years of 1986, 1996 and 2006 were studied. One-year mortality was related to changes in the use of reperfusion strategies and medication at hospital discharge. One-year mortality decreased from 26.3% in 1986 and 19.7% in 1996 to 12.9% in 2006 (P = 0.001). Cox proportional hazard analysis showed that aspirin (HR 0.29), the use of reperfusion therapy (HR 0.51) and beta-blockers at hospital discharge (HR 0.53) were the strongest factors to explain the mortality reduction while the use of diuretics (HR 1.42) and age (HR 1.06) were related to increased one-year mortality. Conclusions The reduction in one-year mortality after myocardial infarction during the last two decades is explained by improved medical management with aspirin, beta-blockers and aggressive reperfusion therapy. Diuretic therapy, refl ecting congestive heart failure, and increased age have negative eff ects on survival. |
author2 |
Landspitali University Hospital, Reykjavik, Iceland |
format |
Article in Journal/Newspaper |
author |
Andersen, K Johannesdottir, B K Kristjansson, J M Gudnason, T |
author_facet |
Andersen, K Johannesdottir, B K Kristjansson, J M Gudnason, T |
author_sort |
Andersen, K |
title |
Decreasing case fatality in myocardial infarction is explained by improved medical treatment |
title_short |
Decreasing case fatality in myocardial infarction is explained by improved medical treatment |
title_full |
Decreasing case fatality in myocardial infarction is explained by improved medical treatment |
title_fullStr |
Decreasing case fatality in myocardial infarction is explained by improved medical treatment |
title_full_unstemmed |
Decreasing case fatality in myocardial infarction is explained by improved medical treatment |
title_sort |
decreasing case fatality in myocardial infarction is explained by improved medical treatment |
publisher |
Association Royale des Societes Scientifiques Medicales Belges/Koninklijke Vereniging van de Belgische Medische Wetenschappelijke Genootschappen |
publishDate |
2011 |
url |
http://hdl.handle.net/2336/125248 https://doi.org/10.2143/AC.66.1.2064965 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://poj.peeters-leuven.be/content.php?url=article&id=2064965 Acta Cardiologica. 2011, 66(1):39-46 0001-5385 doi:10.2143/AC.66.1.2064965 http://hdl.handle.net/2336/125248 Acta Cardiologica |
op_doi |
https://doi.org/10.2143/AC.66.1.2064965 |
_version_ |
1766040806002524160 |