Smoking and a complement gene polymorphism interact in promoting cardiovascular disease morbidity and mortality
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We have demonstrated previously that carriers of a genotype called C4B*Q0 (silent allele of the C4B gene) have a substantially increased risk to suffer from myocardial infarction or stroke,...
Published in: | Clinical and Experimental Immunology |
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Online Access: | http://hdl.handle.net/2336/12493 https://doi.org/10.1111/j.1365-2249.2007.03391.x |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/12493 2023-05-15T16:48:32+02:00 Smoking and a complement gene polymorphism interact in promoting cardiovascular disease morbidity and mortality Arason, G J Kramer, J Blaskó, B Kolka, R Thorbjornsdottir, P Einarsdottir, K Sigfusdottir, A Sigurdarson, S T Sigurdsson, G Rónai, Z Prohászka, Z Sasvari-Székely, M Bodvarsson, S Thorgeirsson, G Füst, G 2007-07-02 YES http://hdl.handle.net/2336/12493 https://doi.org/10.1111/j.1365-2249.2007.03391.x en eng Blackwell Scientific Publications http://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2249.2007.03391.x Clin Exp Immunol 2007, 149(1):132-38 0009-9104 17425651 doi:10.1111/j.1365-2249.2007.03391.x http://hdl.handle.net/2336/12493 Cardiovascular Diseases Polymorphism Genetic Smoking Article 2007 ftlandspitaliuni https://doi.org/10.1111/j.1365-2249.2007.03391.x 2022-05-29T08:20:59Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We have demonstrated previously that carriers of a genotype called C4B*Q0 (silent allele of the C4B gene) have a substantially increased risk to suffer from myocardial infarction or stroke, and are selected out from the healthy elderly population. Because smoking carries a major risk for cardiovascular disease (CVD), it seemed worthwhile to study if these two factors interact. Study 1 involved 74 patients with angina pectoris (AP), 85 patients with recent acute myocardial infarction (AMI) and 112 survivors of a previous AMI and 382 controls from Iceland. Study 2 involved 233 patients with severe CVD and 274 controls from Hungary. Smoking habits were registered for each subject. The number of C4A and C4B genes was determined by phenotyping or genotyping. Compared to controls, C4B*Q0 carrier frequency was significantly higher at diagnosis in Icelandic smokers with AP (P = 0.005) and AMI (P = 0.0003) and Hungarian smokers with severe coronary artery disease (P = 0.023), while no such difference was observed in non-smoking subjects. Age-associated decrease in C4B*Q0 observed previously in two remote Caucasian populations was found, in the present study, to be associated strongly with smoking, and to already occur in smokers after age 50 years both in Iceland and Hungary. Our findings indicate that the C4B*Q0 genotype can be considered as a major covariate of smoking in precipitating the risk for AMI and associated deaths. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Clinical and Experimental Immunology 149 1 132 138 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Cardiovascular Diseases Polymorphism Genetic Smoking |
spellingShingle |
Cardiovascular Diseases Polymorphism Genetic Smoking Arason, G J Kramer, J Blaskó, B Kolka, R Thorbjornsdottir, P Einarsdottir, K Sigfusdottir, A Sigurdarson, S T Sigurdsson, G Rónai, Z Prohászka, Z Sasvari-Székely, M Bodvarsson, S Thorgeirsson, G Füst, G Smoking and a complement gene polymorphism interact in promoting cardiovascular disease morbidity and mortality |
topic_facet |
Cardiovascular Diseases Polymorphism Genetic Smoking |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We have demonstrated previously that carriers of a genotype called C4B*Q0 (silent allele of the C4B gene) have a substantially increased risk to suffer from myocardial infarction or stroke, and are selected out from the healthy elderly population. Because smoking carries a major risk for cardiovascular disease (CVD), it seemed worthwhile to study if these two factors interact. Study 1 involved 74 patients with angina pectoris (AP), 85 patients with recent acute myocardial infarction (AMI) and 112 survivors of a previous AMI and 382 controls from Iceland. Study 2 involved 233 patients with severe CVD and 274 controls from Hungary. Smoking habits were registered for each subject. The number of C4A and C4B genes was determined by phenotyping or genotyping. Compared to controls, C4B*Q0 carrier frequency was significantly higher at diagnosis in Icelandic smokers with AP (P = 0.005) and AMI (P = 0.0003) and Hungarian smokers with severe coronary artery disease (P = 0.023), while no such difference was observed in non-smoking subjects. Age-associated decrease in C4B*Q0 observed previously in two remote Caucasian populations was found, in the present study, to be associated strongly with smoking, and to already occur in smokers after age 50 years both in Iceland and Hungary. Our findings indicate that the C4B*Q0 genotype can be considered as a major covariate of smoking in precipitating the risk for AMI and associated deaths. |
format |
Article in Journal/Newspaper |
author |
Arason, G J Kramer, J Blaskó, B Kolka, R Thorbjornsdottir, P Einarsdottir, K Sigfusdottir, A Sigurdarson, S T Sigurdsson, G Rónai, Z Prohászka, Z Sasvari-Székely, M Bodvarsson, S Thorgeirsson, G Füst, G |
author_facet |
Arason, G J Kramer, J Blaskó, B Kolka, R Thorbjornsdottir, P Einarsdottir, K Sigfusdottir, A Sigurdarson, S T Sigurdsson, G Rónai, Z Prohászka, Z Sasvari-Székely, M Bodvarsson, S Thorgeirsson, G Füst, G |
author_sort |
Arason, G J |
title |
Smoking and a complement gene polymorphism interact in promoting cardiovascular disease morbidity and mortality |
title_short |
Smoking and a complement gene polymorphism interact in promoting cardiovascular disease morbidity and mortality |
title_full |
Smoking and a complement gene polymorphism interact in promoting cardiovascular disease morbidity and mortality |
title_fullStr |
Smoking and a complement gene polymorphism interact in promoting cardiovascular disease morbidity and mortality |
title_full_unstemmed |
Smoking and a complement gene polymorphism interact in promoting cardiovascular disease morbidity and mortality |
title_sort |
smoking and a complement gene polymorphism interact in promoting cardiovascular disease morbidity and mortality |
publisher |
Blackwell Scientific Publications |
publishDate |
2007 |
url |
http://hdl.handle.net/2336/12493 https://doi.org/10.1111/j.1365-2249.2007.03391.x |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2249.2007.03391.x Clin Exp Immunol 2007, 149(1):132-38 0009-9104 17425651 doi:10.1111/j.1365-2249.2007.03391.x http://hdl.handle.net/2336/12493 |
op_doi |
https://doi.org/10.1111/j.1365-2249.2007.03391.x |
container_title |
Clinical and Experimental Immunology |
container_volume |
149 |
container_issue |
1 |
container_start_page |
132 |
op_container_end_page |
138 |
_version_ |
1766038609610145792 |