Skjaldkirtilskrabbamein á Íslandi tímabilið 1955-2004 : klínísk og meinafræðileg faraldsfræðirannsókn
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn Skoða/Opna(view/open) Introduction: Thyroid cancer has been unusually common in Iceland. Histological classification and TNM-staging has altered somewhat in the last decades. The aim of this study was to investiga...
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Læknafélag Íslands, Læknafélag Reykjavíkur
2011
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Online Access: | http://hdl.handle.net/2336/122990 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/122990 2023-05-15T16:46:08+02:00 Skjaldkirtilskrabbamein á Íslandi tímabilið 1955-2004 : klínísk og meinafræðileg faraldsfræðirannsókn Thyroid cancer in Iceland in the period 1955-2004 : a clinico-pathological and epidemiological study Jón Gunnlaugur Jónasson Jón Hrafnkelsson Elínborg Ólafsdóttir 2011-02-25 http://hdl.handle.net/2336/122990 ICE is ice Læknafélag Íslands, Læknafélag Reykjavíkur http://www.laeknabladid.is Læknablaðið 2011, 97(2):83-9 0023-7213 21339522 http://hdl.handle.net/2336/122990 Læknablaðið Skjaldkirtill Krabbamein Faraldsfræði Nýgengi Thyroid Neoplasms Epidemiology Iceland Neoplasm Staging Incidence Article 2011 ftlandspitaliuni 2022-05-29T08:21:42Z Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn Skoða/Opna(view/open) Introduction: Thyroid cancer has been unusually common in Iceland. Histological classification and TNM-staging has altered somewhat in the last decades. The aim of this study was to investigate the epidemiology of thyroid cancer in Iceland over half a century and identify factors affecting survival. Material and methods: Information on all thyroid cancers diagnosed in Iceland from 1955 to 2004 was obtained from the Icelandic Cancer Registry. Tumours diagnosed post-mortem were excluded. The date of diagnosis, sex and age at diagnosis was registered. All histopathology material was re-evaluated to reclassify tumours and TNM-stage was determined. The effect of registered parameters on prognosis was determined both in uni- and multivariate analysis. Results: Out of 805 thyroid cancer cases in the study 588 were in women. The mean age was 51 years in women and 58 years in men. The oscillation of incidence was marked in the study period although it did not increase in the last decades of the study. The overall proportion of papillary carcinoma was around 80% and the proportion of T0-T2 tumours was 66%. Neither number has changed significantly in the last 40 years of the study. The overall disease specific 5 year survival was 88% and increased significantly in the study period. In a multivariate analysis patient's age, year of diagnosis, tumour type and TNM-stage were independent significant prognostic variables. Conclusion: Thyroid cancer incidence in Iceland is no longer different to that in many neighbouring countries. Sex was not an independent prognostic parameter. The year of diagnosis was an independent prognostic factor which might indicate a more efficient treatment in later years. Key words: thyroid cancer, histological classification, TNM-staging, incidence, epidemiology. Correspondence: Jon Gunnlaugur Jonasson, jongj@landspitali.is. Inngangur: Krabbamein í skjaldkirtli eru fremur sjaldgæf æxli þó ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive TNM ENVELOPE(-58.100,-58.100,-62.000,-62.000) Smella ENVELOPE(29.443,29.443,69.896,69.896) |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
Icelandic |
topic |
Skjaldkirtill Krabbamein Faraldsfræði Nýgengi Thyroid Neoplasms Epidemiology Iceland Neoplasm Staging Incidence |
spellingShingle |
Skjaldkirtill Krabbamein Faraldsfræði Nýgengi Thyroid Neoplasms Epidemiology Iceland Neoplasm Staging Incidence Jón Gunnlaugur Jónasson Jón Hrafnkelsson Elínborg Ólafsdóttir Skjaldkirtilskrabbamein á Íslandi tímabilið 1955-2004 : klínísk og meinafræðileg faraldsfræðirannsókn |
topic_facet |
Skjaldkirtill Krabbamein Faraldsfræði Nýgengi Thyroid Neoplasms Epidemiology Iceland Neoplasm Staging Incidence |
description |
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn Skoða/Opna(view/open) Introduction: Thyroid cancer has been unusually common in Iceland. Histological classification and TNM-staging has altered somewhat in the last decades. The aim of this study was to investigate the epidemiology of thyroid cancer in Iceland over half a century and identify factors affecting survival. Material and methods: Information on all thyroid cancers diagnosed in Iceland from 1955 to 2004 was obtained from the Icelandic Cancer Registry. Tumours diagnosed post-mortem were excluded. The date of diagnosis, sex and age at diagnosis was registered. All histopathology material was re-evaluated to reclassify tumours and TNM-stage was determined. The effect of registered parameters on prognosis was determined both in uni- and multivariate analysis. Results: Out of 805 thyroid cancer cases in the study 588 were in women. The mean age was 51 years in women and 58 years in men. The oscillation of incidence was marked in the study period although it did not increase in the last decades of the study. The overall proportion of papillary carcinoma was around 80% and the proportion of T0-T2 tumours was 66%. Neither number has changed significantly in the last 40 years of the study. The overall disease specific 5 year survival was 88% and increased significantly in the study period. In a multivariate analysis patient's age, year of diagnosis, tumour type and TNM-stage were independent significant prognostic variables. Conclusion: Thyroid cancer incidence in Iceland is no longer different to that in many neighbouring countries. Sex was not an independent prognostic parameter. The year of diagnosis was an independent prognostic factor which might indicate a more efficient treatment in later years. Key words: thyroid cancer, histological classification, TNM-staging, incidence, epidemiology. Correspondence: Jon Gunnlaugur Jonasson, jongj@landspitali.is. Inngangur: Krabbamein í skjaldkirtli eru fremur sjaldgæf æxli þó ... |
format |
Article in Journal/Newspaper |
author |
Jón Gunnlaugur Jónasson Jón Hrafnkelsson Elínborg Ólafsdóttir |
author_facet |
Jón Gunnlaugur Jónasson Jón Hrafnkelsson Elínborg Ólafsdóttir |
author_sort |
Jón Gunnlaugur Jónasson |
title |
Skjaldkirtilskrabbamein á Íslandi tímabilið 1955-2004 : klínísk og meinafræðileg faraldsfræðirannsókn |
title_short |
Skjaldkirtilskrabbamein á Íslandi tímabilið 1955-2004 : klínísk og meinafræðileg faraldsfræðirannsókn |
title_full |
Skjaldkirtilskrabbamein á Íslandi tímabilið 1955-2004 : klínísk og meinafræðileg faraldsfræðirannsókn |
title_fullStr |
Skjaldkirtilskrabbamein á Íslandi tímabilið 1955-2004 : klínísk og meinafræðileg faraldsfræðirannsókn |
title_full_unstemmed |
Skjaldkirtilskrabbamein á Íslandi tímabilið 1955-2004 : klínísk og meinafræðileg faraldsfræðirannsókn |
title_sort |
skjaldkirtilskrabbamein á íslandi tímabilið 1955-2004 : klínísk og meinafræðileg faraldsfræðirannsókn |
publisher |
Læknafélag Íslands, Læknafélag Reykjavíkur |
publishDate |
2011 |
url |
http://hdl.handle.net/2336/122990 |
long_lat |
ENVELOPE(-58.100,-58.100,-62.000,-62.000) ENVELOPE(29.443,29.443,69.896,69.896) |
geographic |
TNM Smella |
geographic_facet |
TNM Smella |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.laeknabladid.is Læknablaðið 2011, 97(2):83-9 0023-7213 21339522 http://hdl.handle.net/2336/122990 Læknablaðið |
_version_ |
1766036253476651008 |