Cord blood IgE levels are influenced by gestational age but do not predict allergic manifestations in infants
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The predictive value of cord blood IgE (cIgE) for atopy and related disorders was investigated. Samples were collected from 792 infants delivered consecutively at the National University Ho...
Published in: | Pediatric Allergy and Immunology |
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Online Access: | http://hdl.handle.net/2336/122825 https://doi.org/10.1111/j.1399-3038.1994.tb00211.x |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/122825 2023-05-15T18:07:00+02:00 Cord blood IgE levels are influenced by gestational age but do not predict allergic manifestations in infants Eiriksson, T H Sigurgeirsson, B Ardal, B Sigfusson, A Valdimarsson, H Department of Immunology, National University Hospital, Landspítalinn, Reykjavík, Iceland. 2011-02-24 http://hdl.handle.net/2336/122825 https://doi.org/10.1111/j.1399-3038.1994.tb00211.x en eng Blackwell Publishing http://dx.doi.org/10.1111/j.1399-3038.1994.tb00211.x Blackwell Publishing. 1994, 5(1):5-10 0905-6157 8173640 doi:10.1111/j.1399-3038.1994.tb00211.x http://hdl.handle.net/2336/122825 Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Breast Feeding Enzyme-Linked Immunosorbent Assay Fetal Blood Gestational Age Humans Hypersensitivity Immunoglobulin A Immunoglobulin E Infant Newborn Otitis Media Predictive Value of Tests Prospective Studies Radioimmunoassay Risk Factors Article 2011 ftlandspitaliuni https://doi.org/10.1111/j.1399-3038.1994.tb00211.x 2022-05-29T08:21:42Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The predictive value of cord blood IgE (cIgE) for atopy and related disorders was investigated. Samples were collected from 792 infants delivered consecutively at the National University Hospital in Reykjavík in 1987. The concentration of IgE, but not that of IgA, was found to increase with increasing gestational age at birth. There was no correlation between IgE and IgA levels in individual samples. At the age of 18-23 months 180 of these children were studied for manifestations of allergy and related disorders. Included were all available infants with detectable (> or = 0.23 kU/L) cIgE. However, infants born by Cesarean section or with IgA exceeding 10 mg/L were excluded because of potential contamination with maternal blood. The clinical evaluation was made without knowledge of the IgE levels. Sixty-six of the 180 participants (36.6%) were judged to have had definite allergic manifestations. However, no striking correlation was found between allergic symptoms and cIgE levels in this study, nor did high levels of IgE add significantly to the predictive value of family history. Children with atopic features had more frequently been affected by otitis media. Unexpectedly, infants with intermediate cIgE levels (0.2-0.6 kU/L) were significantly less affected by otitis media than children with unmeasurable (< 0.2 kU/L) or high (> or = 0.7 kU/L) cIgE levels. It is concluded that cord blood IgE can not be used to predict allergic manifestations in children under the age of 2 years. Article in Journal/Newspaper Reykjavík Reykjavík Hirsla - Landspítali University Hospital research archive Reykjavík Pediatric Allergy and Immunology 5 1 5 10 |
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Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Breast Feeding Enzyme-Linked Immunosorbent Assay Fetal Blood Gestational Age Humans Hypersensitivity Immunoglobulin A Immunoglobulin E Infant Newborn Otitis Media Predictive Value of Tests Prospective Studies Radioimmunoassay Risk Factors |
spellingShingle |
Breast Feeding Enzyme-Linked Immunosorbent Assay Fetal Blood Gestational Age Humans Hypersensitivity Immunoglobulin A Immunoglobulin E Infant Newborn Otitis Media Predictive Value of Tests Prospective Studies Radioimmunoassay Risk Factors Eiriksson, T H Sigurgeirsson, B Ardal, B Sigfusson, A Valdimarsson, H Cord blood IgE levels are influenced by gestational age but do not predict allergic manifestations in infants |
topic_facet |
Breast Feeding Enzyme-Linked Immunosorbent Assay Fetal Blood Gestational Age Humans Hypersensitivity Immunoglobulin A Immunoglobulin E Infant Newborn Otitis Media Predictive Value of Tests Prospective Studies Radioimmunoassay Risk Factors |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The predictive value of cord blood IgE (cIgE) for atopy and related disorders was investigated. Samples were collected from 792 infants delivered consecutively at the National University Hospital in Reykjavík in 1987. The concentration of IgE, but not that of IgA, was found to increase with increasing gestational age at birth. There was no correlation between IgE and IgA levels in individual samples. At the age of 18-23 months 180 of these children were studied for manifestations of allergy and related disorders. Included were all available infants with detectable (> or = 0.23 kU/L) cIgE. However, infants born by Cesarean section or with IgA exceeding 10 mg/L were excluded because of potential contamination with maternal blood. The clinical evaluation was made without knowledge of the IgE levels. Sixty-six of the 180 participants (36.6%) were judged to have had definite allergic manifestations. However, no striking correlation was found between allergic symptoms and cIgE levels in this study, nor did high levels of IgE add significantly to the predictive value of family history. Children with atopic features had more frequently been affected by otitis media. Unexpectedly, infants with intermediate cIgE levels (0.2-0.6 kU/L) were significantly less affected by otitis media than children with unmeasurable (< 0.2 kU/L) or high (> or = 0.7 kU/L) cIgE levels. It is concluded that cord blood IgE can not be used to predict allergic manifestations in children under the age of 2 years. |
author2 |
Department of Immunology, National University Hospital, Landspítalinn, Reykjavík, Iceland. |
format |
Article in Journal/Newspaper |
author |
Eiriksson, T H Sigurgeirsson, B Ardal, B Sigfusson, A Valdimarsson, H |
author_facet |
Eiriksson, T H Sigurgeirsson, B Ardal, B Sigfusson, A Valdimarsson, H |
author_sort |
Eiriksson, T H |
title |
Cord blood IgE levels are influenced by gestational age but do not predict allergic manifestations in infants |
title_short |
Cord blood IgE levels are influenced by gestational age but do not predict allergic manifestations in infants |
title_full |
Cord blood IgE levels are influenced by gestational age but do not predict allergic manifestations in infants |
title_fullStr |
Cord blood IgE levels are influenced by gestational age but do not predict allergic manifestations in infants |
title_full_unstemmed |
Cord blood IgE levels are influenced by gestational age but do not predict allergic manifestations in infants |
title_sort |
cord blood ige levels are influenced by gestational age but do not predict allergic manifestations in infants |
publisher |
Blackwell Publishing |
publishDate |
2011 |
url |
http://hdl.handle.net/2336/122825 https://doi.org/10.1111/j.1399-3038.1994.tb00211.x |
geographic |
Reykjavík |
geographic_facet |
Reykjavík |
genre |
Reykjavík Reykjavík |
genre_facet |
Reykjavík Reykjavík |
op_relation |
http://dx.doi.org/10.1111/j.1399-3038.1994.tb00211.x Blackwell Publishing. 1994, 5(1):5-10 0905-6157 8173640 doi:10.1111/j.1399-3038.1994.tb00211.x http://hdl.handle.net/2336/122825 Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology |
op_doi |
https://doi.org/10.1111/j.1399-3038.1994.tb00211.x |
container_title |
Pediatric Allergy and Immunology |
container_volume |
5 |
container_issue |
1 |
container_start_page |
5 |
op_container_end_page |
10 |
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1766178835023265792 |