Excluding linkage between panic disorder and the gamma-aminobutyric acid beta 1 receptor locus in five Icelandic pedigrees.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The GABAA receptor subunits are candidate genes for panic disorder because the receptor is the site of action for the anxiolytic effects of the benzodiazepines. We tested for linkage betwee...
Published in: | Acta Psychiatrica Scandinavica |
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Online Access: | http://hdl.handle.net/2336/122226 https://doi.org/10.1111/j.1600-0447.1993.tb03446.x |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/122226 2023-05-15T16:50:25+02:00 Excluding linkage between panic disorder and the gamma-aminobutyric acid beta 1 receptor locus in five Icelandic pedigrees. Schmidt, S M Zoega, T Crowe, R R Department of Psychiatry, National University Hospital, Reykjavík, Iceland. 2011-02-18 http://hdl.handle.net/2336/122226 https://doi.org/10.1111/j.1600-0447.1993.tb03446.x en eng Wiley-Blackwell http://dx.doi.org/10.1111/j.1600-0447.1993.tb03446.x Acta Psychiatr Scand. 1993, 88(4):225-8 0001-690X 8256635 doi:10.1111/j.1600-0447.1993.tb03446.x http://hdl.handle.net/2336/122226 Acta psychiatrica Scandinavica Adult Female Genetic Linkage Humans Iceland Interviews as Topic Lod Score Male Middle Aged Panic Disorder Pedigree Receptors GABA-A Article 2011 ftlandspitaliuni https://doi.org/10.1111/j.1600-0447.1993.tb03446.x 2022-05-29T08:21:42Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The GABAA receptor subunits are candidate genes for panic disorder because the receptor is the site of action for the anxiolytic effects of the benzodiazepines. We tested for linkage between a tetranucleotide repeat polymorphism at the GABAA beta 1 locus, located on chromosome 4p13-p12, and panic disorder defined by DSM-III-R criteria in 5 Icelandic pedigrees. Both a narrow affection status (definite panic disorder and agoraphobia) and a broad one (including probable cases of these disorders) were tested. With the narrow definition, at a recombination fraction of 0.00, the lod scores in the 5 pedigrees ranged from -3.240 to +0.063, the total score across all 5 pedigrees being -8.299. With the broad definition at the same recombination fraction, the individual lod scores ranged from -2.614 to -0.489, with the total being -8.089. Thus, linkage between panic disorder/agoraphobia and the GABAA beta 1 locus in these pedigrees is exceedingly unlikely. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Acta Psychiatrica Scandinavica 88 4 225 228 |
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Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adult Female Genetic Linkage Humans Iceland Interviews as Topic Lod Score Male Middle Aged Panic Disorder Pedigree Receptors GABA-A |
spellingShingle |
Adult Female Genetic Linkage Humans Iceland Interviews as Topic Lod Score Male Middle Aged Panic Disorder Pedigree Receptors GABA-A Schmidt, S M Zoega, T Crowe, R R Excluding linkage between panic disorder and the gamma-aminobutyric acid beta 1 receptor locus in five Icelandic pedigrees. |
topic_facet |
Adult Female Genetic Linkage Humans Iceland Interviews as Topic Lod Score Male Middle Aged Panic Disorder Pedigree Receptors GABA-A |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The GABAA receptor subunits are candidate genes for panic disorder because the receptor is the site of action for the anxiolytic effects of the benzodiazepines. We tested for linkage between a tetranucleotide repeat polymorphism at the GABAA beta 1 locus, located on chromosome 4p13-p12, and panic disorder defined by DSM-III-R criteria in 5 Icelandic pedigrees. Both a narrow affection status (definite panic disorder and agoraphobia) and a broad one (including probable cases of these disorders) were tested. With the narrow definition, at a recombination fraction of 0.00, the lod scores in the 5 pedigrees ranged from -3.240 to +0.063, the total score across all 5 pedigrees being -8.299. With the broad definition at the same recombination fraction, the individual lod scores ranged from -2.614 to -0.489, with the total being -8.089. Thus, linkage between panic disorder/agoraphobia and the GABAA beta 1 locus in these pedigrees is exceedingly unlikely. |
author2 |
Department of Psychiatry, National University Hospital, Reykjavík, Iceland. |
format |
Article in Journal/Newspaper |
author |
Schmidt, S M Zoega, T Crowe, R R |
author_facet |
Schmidt, S M Zoega, T Crowe, R R |
author_sort |
Schmidt, S M |
title |
Excluding linkage between panic disorder and the gamma-aminobutyric acid beta 1 receptor locus in five Icelandic pedigrees. |
title_short |
Excluding linkage between panic disorder and the gamma-aminobutyric acid beta 1 receptor locus in five Icelandic pedigrees. |
title_full |
Excluding linkage between panic disorder and the gamma-aminobutyric acid beta 1 receptor locus in five Icelandic pedigrees. |
title_fullStr |
Excluding linkage between panic disorder and the gamma-aminobutyric acid beta 1 receptor locus in five Icelandic pedigrees. |
title_full_unstemmed |
Excluding linkage between panic disorder and the gamma-aminobutyric acid beta 1 receptor locus in five Icelandic pedigrees. |
title_sort |
excluding linkage between panic disorder and the gamma-aminobutyric acid beta 1 receptor locus in five icelandic pedigrees. |
publisher |
Wiley-Blackwell |
publishDate |
2011 |
url |
http://hdl.handle.net/2336/122226 https://doi.org/10.1111/j.1600-0447.1993.tb03446.x |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1111/j.1600-0447.1993.tb03446.x Acta Psychiatr Scand. 1993, 88(4):225-8 0001-690X 8256635 doi:10.1111/j.1600-0447.1993.tb03446.x http://hdl.handle.net/2336/122226 Acta psychiatrica Scandinavica |
op_doi |
https://doi.org/10.1111/j.1600-0447.1993.tb03446.x |
container_title |
Acta Psychiatrica Scandinavica |
container_volume |
88 |
container_issue |
4 |
container_start_page |
225 |
op_container_end_page |
228 |
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1766040568727601152 |