Risk of prostate, ovarian, and endometrial cancer among relatives of women with breast cancer
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To investigate the risk of prostate, ovarian, and endometrial cancer among relatives of patients with breast cancer. DESIGN: Cohort study of 947 pedigrees in which the proband ha...
Main Authors: | , , , |
---|---|
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
British Medical Association
2011
|
Subjects: | |
Online Access: | http://hdl.handle.net/2336/121944 |
id |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/121944 |
---|---|
record_format |
openpolar |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/121944 2023-05-15T16:48:32+02:00 Risk of prostate, ovarian, and endometrial cancer among relatives of women with breast cancer Tulinius, H Egilsson, V Olafsdottir, G H Sigvaldason, H Icelandic Cancer Registry, Reykjavik. 2011-02-15 http://hdl.handle.net/2336/121944 en eng British Medical Association http://ukpmc.ac.uk/abstract/MED/1422397 BMJ 1992, 305(6858):855-7 0959-8138 1422397 http://hdl.handle.net/2336/121944 BMJ (Clinical research ed.) Aged 80 and over Breast Neoplasms Cohort Studies Endometrial Neoplasms Female Humans Iceland Male Middle Aged Ovarian Neoplasms Prostatic Neoplasms Risk Factors Article 2011 ftlandspitaliuni 2022-05-29T08:21:42Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To investigate the risk of prostate, ovarian, and endometrial cancer among relatives of patients with breast cancer. DESIGN: Cohort study of 947 pedigrees in which the proband had breast cancer, linked with the Icelandic cancer registry. SETTING: Iceland. SUBJECTS: The 947 pedigrees included 29,725 people, of whom 1539 had breast cancer, 467 had prostate cancer, 135 ovarian cancer, and 105 endometrial cancer. MAIN OUTCOME MEASURES: Risk of prostate, ovarian, and endometrial cancer among blood relatives of women with breast cancer compared with risk in spouses. RESULTS: The risk of prostate cancer was significantly raised for all relatives (1.5), first degree relatives (1.4), and second degree relatives (1.3) of women with breast cancer. Risk of ovarian cancer was raised for all relatives (1.9) and first degree relatives (1.9) and risk of endometrial cancer was raised for all relatives only (1.9). The risk of prostate cancer was raised if the proband with breast cancer had a first degree relative with prostate cancer. CONCLUSIONS: Coaggregation exists between breast cancer and cancers of the prostate, ovaries, and endometrium. This risk relation is probably based on genes which act by increasing the risk for cancer at these sites. Environmental factors that are common among relatives may also play a part. Continued research is required into pathophysiological mechanisms that could explain these observations. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Aged 80 and over Breast Neoplasms Cohort Studies Endometrial Neoplasms Female Humans Iceland Male Middle Aged Ovarian Neoplasms Prostatic Neoplasms Risk Factors |
spellingShingle |
Aged 80 and over Breast Neoplasms Cohort Studies Endometrial Neoplasms Female Humans Iceland Male Middle Aged Ovarian Neoplasms Prostatic Neoplasms Risk Factors Tulinius, H Egilsson, V Olafsdottir, G H Sigvaldason, H Risk of prostate, ovarian, and endometrial cancer among relatives of women with breast cancer |
topic_facet |
Aged 80 and over Breast Neoplasms Cohort Studies Endometrial Neoplasms Female Humans Iceland Male Middle Aged Ovarian Neoplasms Prostatic Neoplasms Risk Factors |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To investigate the risk of prostate, ovarian, and endometrial cancer among relatives of patients with breast cancer. DESIGN: Cohort study of 947 pedigrees in which the proband had breast cancer, linked with the Icelandic cancer registry. SETTING: Iceland. SUBJECTS: The 947 pedigrees included 29,725 people, of whom 1539 had breast cancer, 467 had prostate cancer, 135 ovarian cancer, and 105 endometrial cancer. MAIN OUTCOME MEASURES: Risk of prostate, ovarian, and endometrial cancer among blood relatives of women with breast cancer compared with risk in spouses. RESULTS: The risk of prostate cancer was significantly raised for all relatives (1.5), first degree relatives (1.4), and second degree relatives (1.3) of women with breast cancer. Risk of ovarian cancer was raised for all relatives (1.9) and first degree relatives (1.9) and risk of endometrial cancer was raised for all relatives only (1.9). The risk of prostate cancer was raised if the proband with breast cancer had a first degree relative with prostate cancer. CONCLUSIONS: Coaggregation exists between breast cancer and cancers of the prostate, ovaries, and endometrium. This risk relation is probably based on genes which act by increasing the risk for cancer at these sites. Environmental factors that are common among relatives may also play a part. Continued research is required into pathophysiological mechanisms that could explain these observations. |
author2 |
Icelandic Cancer Registry, Reykjavik. |
format |
Article in Journal/Newspaper |
author |
Tulinius, H Egilsson, V Olafsdottir, G H Sigvaldason, H |
author_facet |
Tulinius, H Egilsson, V Olafsdottir, G H Sigvaldason, H |
author_sort |
Tulinius, H |
title |
Risk of prostate, ovarian, and endometrial cancer among relatives of women with breast cancer |
title_short |
Risk of prostate, ovarian, and endometrial cancer among relatives of women with breast cancer |
title_full |
Risk of prostate, ovarian, and endometrial cancer among relatives of women with breast cancer |
title_fullStr |
Risk of prostate, ovarian, and endometrial cancer among relatives of women with breast cancer |
title_full_unstemmed |
Risk of prostate, ovarian, and endometrial cancer among relatives of women with breast cancer |
title_sort |
risk of prostate, ovarian, and endometrial cancer among relatives of women with breast cancer |
publisher |
British Medical Association |
publishDate |
2011 |
url |
http://hdl.handle.net/2336/121944 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://ukpmc.ac.uk/abstract/MED/1422397 BMJ 1992, 305(6858):855-7 0959-8138 1422397 http://hdl.handle.net/2336/121944 BMJ (Clinical research ed.) |
_version_ |
1766038611907575808 |