Vertebral bone density in Icelandic women using quantitative computed tomography without an external reference phantom

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Vertebral trabecular bone mineral density (BMD) was measured in 187 healthy Icelandic women, age 35-64 years, by quantitative computed tomography (QCT) with the use of internal references (...

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Bibliographic Details
Published in:Osteoporosis International
Main Authors: Gudmundsdottir, H, Jonsdottir, B, Kristinsson, S, Johannesson, A, Goodenough, D, Sigurdsson, G
Other Authors: Department of Internal Medicine, Reykjavík City Hospital, Iceland.
Format: Article in Journal/Newspaper
Language:English
Published: Springer 2011
Subjects:
Adult
Bone Density
Female
Humans
Iceland
Middle Aged
Spine
Tomography
X-Ray Computed
Online Access:http://hdl.handle.net/2336/121053
https://doi.org/10.1007/BF01623378
Description
Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Vertebral trabecular bone mineral density (BMD) was measured in 187 healthy Icelandic women, age 35-64 years, by quantitative computed tomography (QCT) with the use of internal references (muscle and subcutaneous fat) instead of the traditional external references (phantoms). We found a mean 2.4 mg/cm3 (1.8%) bone loss per year in the age range 35-64 years. There was an accelerated phase (exponential) after menopause, with 4% loss per year for the first 1-5 years after menopause or 5-fold trabecular bone loss compared with the subsequent 11-15 years after menopause. Reproducibility was found to be 1.9%. This method thus compares with traditional QCT measurements and is highly reproducible. We find QCT using internal references a promising method for assessing fracture risk in perimenopausal women and for follow-up in osteoporotic patients.

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