Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Persons with type 2 diabetes are at increased risk of cognitive dysfunction. Less is known about which cognitive abilities are affected and how undiagnosed diabetes and impaired fasting glu...
Published in: | American Journal of Epidemiology |
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Online Access: | http://hdl.handle.net/2336/120805 https://doi.org/10.1093/aje/kwn228 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/120805 2023-05-15T16:51:28+02:00 Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study Saczynski, Jane S Jonsdottir, María K Garcia, Melissa E Jonsson, Palmi V Peila, Rita Eiriksdottir, Gudny Olafsdottir, Elin Harris, Tamara B Gudnason, Vilmundur Launer, Lenore J Division of Geriatric Medicine, University of Massachusetts Medical School, Biotech Four, Suite 315, 377 Plantation Street, Worcester, MA 01605, USA. jane.saczynski@umassmed.edu 2011-02-01 http://hdl.handle.net/2336/120805 https://doi.org/10.1093/aje/kwn228 en eng http://dx.doi.org/10.1093/aje/kwn228 Am. J. Epidemiol. 2008, 168(10):1132-9 1476-6256 18836152 doi:10.1093/aje/kwn228 http://hdl.handle.net/2336/120805 American journal of epidemiology Aged Blood Glucose Cognition Disorders Cohort Studies Diabetes Mellitus Type 2 Environment Fasting Female Genetic Predisposition to Disease Glycemic Index Hemoglobin A Glycosylated Humans Iceland Logistic Models Male Psychological Tests Questionnaires Article 2011 ftlandspitaliuni https://doi.org/10.1093/aje/kwn228 2022-05-29T08:21:41Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Persons with type 2 diabetes are at increased risk of cognitive dysfunction. Less is known about which cognitive abilities are affected and how undiagnosed diabetes and impaired fasting glucose relate to cognitive performance. The authors explored this question using data from 1,917 nondemented men and women (average age = 76 years) in the population-based Age, Gene/Environment Susceptibility-Reykjavik Study (2002-2006). Glycemic status groups included diagnosed diabetes (self-reported diabetes or diabetic medication use; n = 163 (8.5%)), undiagnosed diabetes (fasting blood glucose >or=7.0 mmol/L without diagnosed diabetes; n = 55 (2.9%)), and impaired fasting glucose (fasting blood glucose 5.6-6.9 mmol/L; n = 744 (38.8%)). Composites of memory, processing speed (PS), and executive function were constructed from a neuropsychological battery. Linear regression was used to investigate cross-sectional differences in cognitive performance between glycemic groups, adjusted for demographic and health factors. Persons with diagnosed diabetes had slower PS than normoglycemics (beta = -0.12; P < 0.05); diabetes duration of >or=15 years was associated with significantly poorer PS and executive function. Undiagnosed diabetics had slower PS (beta = -0.22; P < 0.01) and poorer memory performance (beta = -0.22; P < 0.05). Persons with type 2 diabetes have poorer cognitive performance than normoglycemics, particularly in PS. Those with undiagnosed diabetes have the lowest cognitive performance. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive American Journal of Epidemiology 168 10 1132 1139 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Aged Blood Glucose Cognition Disorders Cohort Studies Diabetes Mellitus Type 2 Environment Fasting Female Genetic Predisposition to Disease Glycemic Index Hemoglobin A Glycosylated Humans Iceland Logistic Models Male Psychological Tests Questionnaires |
spellingShingle |
Aged Blood Glucose Cognition Disorders Cohort Studies Diabetes Mellitus Type 2 Environment Fasting Female Genetic Predisposition to Disease Glycemic Index Hemoglobin A Glycosylated Humans Iceland Logistic Models Male Psychological Tests Questionnaires Saczynski, Jane S Jonsdottir, María K Garcia, Melissa E Jonsson, Palmi V Peila, Rita Eiriksdottir, Gudny Olafsdottir, Elin Harris, Tamara B Gudnason, Vilmundur Launer, Lenore J Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study |
topic_facet |
Aged Blood Glucose Cognition Disorders Cohort Studies Diabetes Mellitus Type 2 Environment Fasting Female Genetic Predisposition to Disease Glycemic Index Hemoglobin A Glycosylated Humans Iceland Logistic Models Male Psychological Tests Questionnaires |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Persons with type 2 diabetes are at increased risk of cognitive dysfunction. Less is known about which cognitive abilities are affected and how undiagnosed diabetes and impaired fasting glucose relate to cognitive performance. The authors explored this question using data from 1,917 nondemented men and women (average age = 76 years) in the population-based Age, Gene/Environment Susceptibility-Reykjavik Study (2002-2006). Glycemic status groups included diagnosed diabetes (self-reported diabetes or diabetic medication use; n = 163 (8.5%)), undiagnosed diabetes (fasting blood glucose >or=7.0 mmol/L without diagnosed diabetes; n = 55 (2.9%)), and impaired fasting glucose (fasting blood glucose 5.6-6.9 mmol/L; n = 744 (38.8%)). Composites of memory, processing speed (PS), and executive function were constructed from a neuropsychological battery. Linear regression was used to investigate cross-sectional differences in cognitive performance between glycemic groups, adjusted for demographic and health factors. Persons with diagnosed diabetes had slower PS than normoglycemics (beta = -0.12; P < 0.05); diabetes duration of >or=15 years was associated with significantly poorer PS and executive function. Undiagnosed diabetics had slower PS (beta = -0.22; P < 0.01) and poorer memory performance (beta = -0.22; P < 0.05). Persons with type 2 diabetes have poorer cognitive performance than normoglycemics, particularly in PS. Those with undiagnosed diabetes have the lowest cognitive performance. |
author2 |
Division of Geriatric Medicine, University of Massachusetts Medical School, Biotech Four, Suite 315, 377 Plantation Street, Worcester, MA 01605, USA. jane.saczynski@umassmed.edu |
format |
Article in Journal/Newspaper |
author |
Saczynski, Jane S Jonsdottir, María K Garcia, Melissa E Jonsson, Palmi V Peila, Rita Eiriksdottir, Gudny Olafsdottir, Elin Harris, Tamara B Gudnason, Vilmundur Launer, Lenore J |
author_facet |
Saczynski, Jane S Jonsdottir, María K Garcia, Melissa E Jonsson, Palmi V Peila, Rita Eiriksdottir, Gudny Olafsdottir, Elin Harris, Tamara B Gudnason, Vilmundur Launer, Lenore J |
author_sort |
Saczynski, Jane S |
title |
Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study |
title_short |
Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study |
title_full |
Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study |
title_fullStr |
Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study |
title_full_unstemmed |
Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study |
title_sort |
cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--reykjavik study |
publishDate |
2011 |
url |
http://hdl.handle.net/2336/120805 https://doi.org/10.1093/aje/kwn228 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1093/aje/kwn228 Am. J. Epidemiol. 2008, 168(10):1132-9 1476-6256 18836152 doi:10.1093/aje/kwn228 http://hdl.handle.net/2336/120805 American journal of epidemiology |
op_doi |
https://doi.org/10.1093/aje/kwn228 |
container_title |
American Journal of Epidemiology |
container_volume |
168 |
container_issue |
10 |
container_start_page |
1132 |
op_container_end_page |
1139 |
_version_ |
1766041579279089664 |