Association of immunoglobulin A deficiency and elevated thyrotropin-receptor autoantibodies in two Nordic countries
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency, with suggested association with various types of autoimmunity, including Graves' disease. This study inv...
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/120045 2023-05-15T16:48:21+02:00 Association of immunoglobulin A deficiency and elevated thyrotropin-receptor autoantibodies in two Nordic countries Jorgensen, Gudmundur H Ornolfsson, Arni E Johannesson, Ari Gudmundsson, Sveinn Janzi, Magdalena Wang, Ning Hammarström, Lennart Ludviksson, Bjorn R Department of Medicine, University of Iceland, Reykjavík, Iceland; Department of Immunology, Landspitali-University Hospital, Reykjavík, Iceland. 2011-01-20 http://hdl.handle.net/2336/120045 https://doi.org/10.1016/j.humimm.2010.10.014 en eng Elsevier/North-Holland http://dx.doi.org/10.1016/j.humimm.2010.10.014 Hum. Immunol. 2011, 72(2):166-72 1879-1166 20977916 doi:10.1016/j.humimm.2010.10.014 http://hdl.handle.net/2336/120045 Human immunology gA Deficiency Immunoglobulins HLA Antigens PubMed in process Article 2011 ftlandspitaliuni https://doi.org/10.1016/j.humimm.2010.10.014 2022-05-29T08:21:41Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency, with suggested association with various types of autoimmunity, including Graves' disease. This study investigated the association of IgAD with elevated thyrotropin-receptor autoantibodies (TRAb). IgA was measured in TRAb-seropositive individuals from both Iceland (N = 299] and Sweden (N = 841]. In addition, TRAb levels were evaluated in 43 Icelandic and 50 Swedish IgAD individuals using Medizym TRA immunoassay, and positive samples were re-evaluated using BRAHMS TRAK human RIA. The IgAD individuals were HLA-genotyped to determine the HLA-B, DR, and DQ alleles. None of the 299 Icelandic TRAb-seropositive individuals had IgAD, whereas, a high prevalence of IgAD (14/841 (1:60)) was observed in the Swedish cohort (p = 0.027). The prevalence of TRAb-seropositivity in IgAD individuals was, however, increased in both cohorts. The HLA-DQ6 allele was associated with TRAb-seronegativity within the Icelandic IgAD cohort (p = 0.037). The prevalence of IgAD in TRAb-seropositive individuals in Sweden is 10 times higher than expected in the general population. Furthermore, TRAb seropositivity is common among IgAD individuals, both in Iceland and Sweden, suggesting a predisposition toward Graves' disease. These findings underline the significant association of IgAD with autoimmunity and its possible association with certain HLA-DQ alleles. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Human Immunology 72 2 166 172 |
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Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
gA Deficiency Immunoglobulins HLA Antigens PubMed in process |
spellingShingle |
gA Deficiency Immunoglobulins HLA Antigens PubMed in process Jorgensen, Gudmundur H Ornolfsson, Arni E Johannesson, Ari Gudmundsson, Sveinn Janzi, Magdalena Wang, Ning Hammarström, Lennart Ludviksson, Bjorn R Association of immunoglobulin A deficiency and elevated thyrotropin-receptor autoantibodies in two Nordic countries |
topic_facet |
gA Deficiency Immunoglobulins HLA Antigens PubMed in process |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency, with suggested association with various types of autoimmunity, including Graves' disease. This study investigated the association of IgAD with elevated thyrotropin-receptor autoantibodies (TRAb). IgA was measured in TRAb-seropositive individuals from both Iceland (N = 299] and Sweden (N = 841]. In addition, TRAb levels were evaluated in 43 Icelandic and 50 Swedish IgAD individuals using Medizym TRA immunoassay, and positive samples were re-evaluated using BRAHMS TRAK human RIA. The IgAD individuals were HLA-genotyped to determine the HLA-B, DR, and DQ alleles. None of the 299 Icelandic TRAb-seropositive individuals had IgAD, whereas, a high prevalence of IgAD (14/841 (1:60)) was observed in the Swedish cohort (p = 0.027). The prevalence of TRAb-seropositivity in IgAD individuals was, however, increased in both cohorts. The HLA-DQ6 allele was associated with TRAb-seronegativity within the Icelandic IgAD cohort (p = 0.037). The prevalence of IgAD in TRAb-seropositive individuals in Sweden is 10 times higher than expected in the general population. Furthermore, TRAb seropositivity is common among IgAD individuals, both in Iceland and Sweden, suggesting a predisposition toward Graves' disease. These findings underline the significant association of IgAD with autoimmunity and its possible association with certain HLA-DQ alleles. |
author2 |
Department of Medicine, University of Iceland, Reykjavík, Iceland; Department of Immunology, Landspitali-University Hospital, Reykjavík, Iceland. |
format |
Article in Journal/Newspaper |
author |
Jorgensen, Gudmundur H Ornolfsson, Arni E Johannesson, Ari Gudmundsson, Sveinn Janzi, Magdalena Wang, Ning Hammarström, Lennart Ludviksson, Bjorn R |
author_facet |
Jorgensen, Gudmundur H Ornolfsson, Arni E Johannesson, Ari Gudmundsson, Sveinn Janzi, Magdalena Wang, Ning Hammarström, Lennart Ludviksson, Bjorn R |
author_sort |
Jorgensen, Gudmundur H |
title |
Association of immunoglobulin A deficiency and elevated thyrotropin-receptor autoantibodies in two Nordic countries |
title_short |
Association of immunoglobulin A deficiency and elevated thyrotropin-receptor autoantibodies in two Nordic countries |
title_full |
Association of immunoglobulin A deficiency and elevated thyrotropin-receptor autoantibodies in two Nordic countries |
title_fullStr |
Association of immunoglobulin A deficiency and elevated thyrotropin-receptor autoantibodies in two Nordic countries |
title_full_unstemmed |
Association of immunoglobulin A deficiency and elevated thyrotropin-receptor autoantibodies in two Nordic countries |
title_sort |
association of immunoglobulin a deficiency and elevated thyrotropin-receptor autoantibodies in two nordic countries |
publisher |
Elsevier/North-Holland |
publishDate |
2011 |
url |
http://hdl.handle.net/2336/120045 https://doi.org/10.1016/j.humimm.2010.10.014 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1016/j.humimm.2010.10.014 Hum. Immunol. 2011, 72(2):166-72 1879-1166 20977916 doi:10.1016/j.humimm.2010.10.014 http://hdl.handle.net/2336/120045 Human immunology |
op_doi |
https://doi.org/10.1016/j.humimm.2010.10.014 |
container_title |
Human Immunology |
container_volume |
72 |
container_issue |
2 |
container_start_page |
166 |
op_container_end_page |
172 |
_version_ |
1766038457302384640 |