High levodopa use in periodically time-clustered, Icelandic birth cohorts. A vestige of parkinsonism etiology? Europarkinson Preparatory Activity Research Group
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We evaluated levodopa use (LDU) by the Icelandic population focusing on: 1) annual gross levodopa (LD) sales from wholesalers to pharmacies for the period 1978-1990, using a reported method...
Published in: | Acta Neurologica Scandinavica |
---|---|
Main Authors: | , , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2011
|
Subjects: | |
Online Access: | http://hdl.handle.net/2336/119385 https://doi.org/10.1111/j.1600-0404.1995.tb00412.x |
id |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/119385 |
---|---|
record_format |
openpolar |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/119385 2023-05-15T16:46:23+02:00 High levodopa use in periodically time-clustered, Icelandic birth cohorts. A vestige of parkinsonism etiology? Europarkinson Preparatory Activity Research Group de Pedro-Cuesta, J Petersen, I J Stawiarz, L Gudmundsson, G Almazán, J Tulinius, H Johansson, H Division of Neurology, Huddinge University Hospital, Karolinska Institute, Sweden. 2011-01-14 http://hdl.handle.net/2336/119385 https://doi.org/10.1111/j.1600-0404.1995.tb00412.x en eng Wiley http://dx.doi.org/10.1111/j.1600-0404.1995.tb00412.x Acta Neurol. Scand. 1995, 91(2):79-88 0001-6314 7785429 doi:10.1111/j.1600-0404.1995.tb00412.x http://hdl.handle.net/2336/119385 Acta neurologica Scandinavica Adult Aged 80 and over Antiparkinson Agents Cluster Analysis Cohort Studies Cross-Cultural Comparison Drug Prescriptions Drug Utilization Female Humans Iceland Levodopa Male Middle Aged Parkinson Disease Sweden Whooping Cough Article 2011 ftlandspitaliuni https://doi.org/10.1111/j.1600-0404.1995.tb00412.x 2022-05-29T08:21:41Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We evaluated levodopa use (LDU) by the Icelandic population focusing on: 1) annual gross levodopa (LD) sales from wholesalers to pharmacies for the period 1978-1990, using a reported method; 2) data from a prescription survey conducted from October 1st, 1990 to March 31st, 1991; and 3)raw and reported data on prevalences of Parkinson's disease (PD) in 1963 in this country. The standard for adjustments and reference population for LDU comparisons was the Swedish in 1984. Crude gross sales of LD in Iceland in 1990 and in Sweden in 1984 amounted to 1.67 and 1.35 DDD/1000 person days respectively. After respective adjustments for age, and for age and the infant mortality rates, taken as an indicator of health care quality, LDU in Iceland in 1990 was found to be 1.82 and 1.63 (95% CI 1.47-1.89) times that for Sweden. Prevalences of LD-prescription recipients in 1990-1991 and of PD in 1963 increased with age; however, those of drug users were higher than those of PD among the elderly. Higher-than-expected prevalences of PD and LD-prescription users (there being a partial overlap between these two categories) were found in periodically-clustered, one-year birth cohorts. These results support the notion that Iceland has a high LDU and suggest that this variation is due to a high prevalence of LD responsive disorders. Cohorts born after registered whooping cough outbreaks in Iceland may account for the magnitude and birth-related pattern of PD prevalences and LDU levels. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Acta Neurologica Scandinavica 91 2 79 88 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adult Aged 80 and over Antiparkinson Agents Cluster Analysis Cohort Studies Cross-Cultural Comparison Drug Prescriptions Drug Utilization Female Humans Iceland Levodopa Male Middle Aged Parkinson Disease Sweden Whooping Cough |
spellingShingle |
Adult Aged 80 and over Antiparkinson Agents Cluster Analysis Cohort Studies Cross-Cultural Comparison Drug Prescriptions Drug Utilization Female Humans Iceland Levodopa Male Middle Aged Parkinson Disease Sweden Whooping Cough de Pedro-Cuesta, J Petersen, I J Stawiarz, L Gudmundsson, G Almazán, J Tulinius, H Johansson, H High levodopa use in periodically time-clustered, Icelandic birth cohorts. A vestige of parkinsonism etiology? Europarkinson Preparatory Activity Research Group |
topic_facet |
Adult Aged 80 and over Antiparkinson Agents Cluster Analysis Cohort Studies Cross-Cultural Comparison Drug Prescriptions Drug Utilization Female Humans Iceland Levodopa Male Middle Aged Parkinson Disease Sweden Whooping Cough |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We evaluated levodopa use (LDU) by the Icelandic population focusing on: 1) annual gross levodopa (LD) sales from wholesalers to pharmacies for the period 1978-1990, using a reported method; 2) data from a prescription survey conducted from October 1st, 1990 to March 31st, 1991; and 3)raw and reported data on prevalences of Parkinson's disease (PD) in 1963 in this country. The standard for adjustments and reference population for LDU comparisons was the Swedish in 1984. Crude gross sales of LD in Iceland in 1990 and in Sweden in 1984 amounted to 1.67 and 1.35 DDD/1000 person days respectively. After respective adjustments for age, and for age and the infant mortality rates, taken as an indicator of health care quality, LDU in Iceland in 1990 was found to be 1.82 and 1.63 (95% CI 1.47-1.89) times that for Sweden. Prevalences of LD-prescription recipients in 1990-1991 and of PD in 1963 increased with age; however, those of drug users were higher than those of PD among the elderly. Higher-than-expected prevalences of PD and LD-prescription users (there being a partial overlap between these two categories) were found in periodically-clustered, one-year birth cohorts. These results support the notion that Iceland has a high LDU and suggest that this variation is due to a high prevalence of LD responsive disorders. Cohorts born after registered whooping cough outbreaks in Iceland may account for the magnitude and birth-related pattern of PD prevalences and LDU levels. |
author2 |
Division of Neurology, Huddinge University Hospital, Karolinska Institute, Sweden. |
format |
Article in Journal/Newspaper |
author |
de Pedro-Cuesta, J Petersen, I J Stawiarz, L Gudmundsson, G Almazán, J Tulinius, H Johansson, H |
author_facet |
de Pedro-Cuesta, J Petersen, I J Stawiarz, L Gudmundsson, G Almazán, J Tulinius, H Johansson, H |
author_sort |
de Pedro-Cuesta, J |
title |
High levodopa use in periodically time-clustered, Icelandic birth cohorts. A vestige of parkinsonism etiology? Europarkinson Preparatory Activity Research Group |
title_short |
High levodopa use in periodically time-clustered, Icelandic birth cohorts. A vestige of parkinsonism etiology? Europarkinson Preparatory Activity Research Group |
title_full |
High levodopa use in periodically time-clustered, Icelandic birth cohorts. A vestige of parkinsonism etiology? Europarkinson Preparatory Activity Research Group |
title_fullStr |
High levodopa use in periodically time-clustered, Icelandic birth cohorts. A vestige of parkinsonism etiology? Europarkinson Preparatory Activity Research Group |
title_full_unstemmed |
High levodopa use in periodically time-clustered, Icelandic birth cohorts. A vestige of parkinsonism etiology? Europarkinson Preparatory Activity Research Group |
title_sort |
high levodopa use in periodically time-clustered, icelandic birth cohorts. a vestige of parkinsonism etiology? europarkinson preparatory activity research group |
publisher |
Wiley |
publishDate |
2011 |
url |
http://hdl.handle.net/2336/119385 https://doi.org/10.1111/j.1600-0404.1995.tb00412.x |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1111/j.1600-0404.1995.tb00412.x Acta Neurol. Scand. 1995, 91(2):79-88 0001-6314 7785429 doi:10.1111/j.1600-0404.1995.tb00412.x http://hdl.handle.net/2336/119385 Acta neurologica Scandinavica |
op_doi |
https://doi.org/10.1111/j.1600-0404.1995.tb00412.x |
container_title |
Acta Neurologica Scandinavica |
container_volume |
91 |
container_issue |
2 |
container_start_page |
79 |
op_container_end_page |
88 |
_version_ |
1766036487612137472 |