Early and treatment-related deaths in childhood acute myeloid leukaemia in the Nordic countries: 1984-2003
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Despite major improvements in the cure rate of childhood acute myeloid leukaemia (AML), 5-15% of patients still die from treatment-related complications. In a historical prospective cohort...
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Online Access: | http://hdl.handle.net/2336/119047 https://doi.org/10.1111/j.1365-2141.2010.08389.x |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/119047 2023-05-15T16:51:12+02:00 Early and treatment-related deaths in childhood acute myeloid leukaemia in the Nordic countries: 1984-2003 Molgaard-Hansen, Lene Möttönen, Merja Glosli, Heidi Jonmundsson, Gudmundur K Abrahamsson, Jonas Hasle, Henrik Department of Paediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark. lene.molgaard@dadlnet.dk 2011-01-10 http://hdl.handle.net/2336/119047 https://doi.org/10.1111/j.1365-2141.2010.08389.x en eng Wiley-Blackwell http://dx.doi.org/10.1111/j.1365-2141.2010.08389.x Br. J. Haematol. 2010, 151(5):447-59 1365-2141 20955398 doi:10.1111/j.1365-2141.2010.08389.x http://hdl.handle.net/2336/119047 British journal of haematology Adolescent Age Distribution Antineoplastic Combined Chemotherapy Protocols Child Preschool Epidemiologic Methods Finland Heart Failure Humans Iceland Infant Leukemia Myeloid Acute Opportunistic Infections Scandinavia Sex Distribution Time Factors Article 2011 ftlandspitaliuni https://doi.org/10.1111/j.1365-2141.2010.08389.x 2022-05-29T08:21:41Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Despite major improvements in the cure rate of childhood acute myeloid leukaemia (AML), 5-15% of patients still die from treatment-related complications. In a historical prospective cohort study, we analysed the frequency, clinical features and risk factors for early deaths (ED) and treatment-related deaths (TRD) in 525 children included in the Nordic Society of Paediatric Haematology and Oncology (NOPHO)-AML-84, -88 and -93 trials. Seventy patients (13%) died before starting treatment or from treatment-related complications. The death rate rose from 11% in NOPHO-AML-84 to 29% in -88, but then fell to 8% in -93. Sixteen patients (3%) died within the first 2 weeks, mainly from bleeding or leucostasis. Hyperleucocytosis, age <2 or ≥10 years were risk factors. After day 15, 10% of patients died from treatment-related complications with infection as the main cause of death. Risk factors were age <2 or ≥10 years and treatment according to the NOPHO-AML-88 protocol. The number of EDs and TRDs in AML is high. Therefore optimal antifungal prophylaxis is essential, and studies on the benefit of antibacterial prophylaxis and individual risk factors for ED and TRD are needed. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive British Journal of Haematology 151 5 447 459 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adolescent Age Distribution Antineoplastic Combined Chemotherapy Protocols Child Preschool Epidemiologic Methods Finland Heart Failure Humans Iceland Infant Leukemia Myeloid Acute Opportunistic Infections Scandinavia Sex Distribution Time Factors |
spellingShingle |
Adolescent Age Distribution Antineoplastic Combined Chemotherapy Protocols Child Preschool Epidemiologic Methods Finland Heart Failure Humans Iceland Infant Leukemia Myeloid Acute Opportunistic Infections Scandinavia Sex Distribution Time Factors Molgaard-Hansen, Lene Möttönen, Merja Glosli, Heidi Jonmundsson, Gudmundur K Abrahamsson, Jonas Hasle, Henrik Early and treatment-related deaths in childhood acute myeloid leukaemia in the Nordic countries: 1984-2003 |
topic_facet |
Adolescent Age Distribution Antineoplastic Combined Chemotherapy Protocols Child Preschool Epidemiologic Methods Finland Heart Failure Humans Iceland Infant Leukemia Myeloid Acute Opportunistic Infections Scandinavia Sex Distribution Time Factors |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Despite major improvements in the cure rate of childhood acute myeloid leukaemia (AML), 5-15% of patients still die from treatment-related complications. In a historical prospective cohort study, we analysed the frequency, clinical features and risk factors for early deaths (ED) and treatment-related deaths (TRD) in 525 children included in the Nordic Society of Paediatric Haematology and Oncology (NOPHO)-AML-84, -88 and -93 trials. Seventy patients (13%) died before starting treatment or from treatment-related complications. The death rate rose from 11% in NOPHO-AML-84 to 29% in -88, but then fell to 8% in -93. Sixteen patients (3%) died within the first 2 weeks, mainly from bleeding or leucostasis. Hyperleucocytosis, age <2 or ≥10 years were risk factors. After day 15, 10% of patients died from treatment-related complications with infection as the main cause of death. Risk factors were age <2 or ≥10 years and treatment according to the NOPHO-AML-88 protocol. The number of EDs and TRDs in AML is high. Therefore optimal antifungal prophylaxis is essential, and studies on the benefit of antibacterial prophylaxis and individual risk factors for ED and TRD are needed. |
author2 |
Department of Paediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark. lene.molgaard@dadlnet.dk |
format |
Article in Journal/Newspaper |
author |
Molgaard-Hansen, Lene Möttönen, Merja Glosli, Heidi Jonmundsson, Gudmundur K Abrahamsson, Jonas Hasle, Henrik |
author_facet |
Molgaard-Hansen, Lene Möttönen, Merja Glosli, Heidi Jonmundsson, Gudmundur K Abrahamsson, Jonas Hasle, Henrik |
author_sort |
Molgaard-Hansen, Lene |
title |
Early and treatment-related deaths in childhood acute myeloid leukaemia in the Nordic countries: 1984-2003 |
title_short |
Early and treatment-related deaths in childhood acute myeloid leukaemia in the Nordic countries: 1984-2003 |
title_full |
Early and treatment-related deaths in childhood acute myeloid leukaemia in the Nordic countries: 1984-2003 |
title_fullStr |
Early and treatment-related deaths in childhood acute myeloid leukaemia in the Nordic countries: 1984-2003 |
title_full_unstemmed |
Early and treatment-related deaths in childhood acute myeloid leukaemia in the Nordic countries: 1984-2003 |
title_sort |
early and treatment-related deaths in childhood acute myeloid leukaemia in the nordic countries: 1984-2003 |
publisher |
Wiley-Blackwell |
publishDate |
2011 |
url |
http://hdl.handle.net/2336/119047 https://doi.org/10.1111/j.1365-2141.2010.08389.x |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1111/j.1365-2141.2010.08389.x Br. J. Haematol. 2010, 151(5):447-59 1365-2141 20955398 doi:10.1111/j.1365-2141.2010.08389.x http://hdl.handle.net/2336/119047 British journal of haematology |
op_doi |
https://doi.org/10.1111/j.1365-2141.2010.08389.x |
container_title |
British Journal of Haematology |
container_volume |
151 |
container_issue |
5 |
container_start_page |
447 |
op_container_end_page |
459 |
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1766041312792936448 |