Replication error in human breast cancer: comparison with clinical variables and family history of cancer.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Replication errors (RER) at microsatellite repeats indicate genomic instability in hereditary nonpolyposis colorectal cancer (HNPCC) and in some sporadic cancers. We have studied genomic in...
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/118946 2023-05-15T16:51:12+02:00 Replication error in human breast cancer: comparison with clinical variables and family history of cancer. Huiping, C Johannsdottir, J T Arason, A Olafsdottir, G H Eiriksdottir, G Egilsson, V Ingvarsson, S Department of Pathology, University and National Hospital of Iceland, Reykjavik, Iceland. 2011-01-07 http://hdl.handle.net/2336/118946 en eng D.A. Spandidos http://www.spandidos-publications.com/or/ Oncol. Rep. 1999, 6(1):117-22 1021-335X 9864413 http://hdl.handle.net/2336/118946 Oncology reports Adult Age of Onset Aged 80 and over Aneuploidy BRCA2 Protein Breast Neoplasms Carcinoma Ductal Breast Chromosomes Human DNA Replication DNA Neoplasm Estrogens Family Health Female Heterozygote Humans Iceland Loss of Heterozygosity Male Microsatellite Repeats Middle Aged Neoplasm Proteins Neoplasms Hormone-Dependent Polymerase Chain Reaction Progesterone Sequence Deletion Transcription Factors Article 2011 ftlandspitaliuni 2022-05-29T08:21:41Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Replication errors (RER) at microsatellite repeats indicate genomic instability in hereditary nonpolyposis colorectal cancer (HNPCC) and in some sporadic cancers. We have studied genomic instability in 313 sporadic breast tumors and in 106 tumors from BRCA2, 999del5 carriers at 43 genomic loci on 13 chromosomes. RER was observed in 8/419 (1.9%) of the cases at one or more chromosomal loci. The frequencies of type I and type II RER were similar. The majority of RER+ tumors showed ER+, PgR+, high S-phase fraction, tumor size >2 cm and LOH at 2p, 2q and 3p. All 8 RER+ tumors were of the ductal histotype. The breast cancer cases with RER are not part of an HNPCC syndrome and a family history of colorectal cancer growth is not detected in relatives, with the exception of one case. However, four of the RER+ cases are from individuals carrying the BRCA2, 999del5 mutation. We conclude that RER is a rare somatic event during human breast carcinogenesis and may be associated with progression of breast carcinomas. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive |
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Hirsla - Landspítali University Hospital research archive |
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ftlandspitaliuni |
language |
English |
topic |
Adult Age of Onset Aged 80 and over Aneuploidy BRCA2 Protein Breast Neoplasms Carcinoma Ductal Breast Chromosomes Human DNA Replication DNA Neoplasm Estrogens Family Health Female Heterozygote Humans Iceland Loss of Heterozygosity Male Microsatellite Repeats Middle Aged Neoplasm Proteins Neoplasms Hormone-Dependent Polymerase Chain Reaction Progesterone Sequence Deletion Transcription Factors |
spellingShingle |
Adult Age of Onset Aged 80 and over Aneuploidy BRCA2 Protein Breast Neoplasms Carcinoma Ductal Breast Chromosomes Human DNA Replication DNA Neoplasm Estrogens Family Health Female Heterozygote Humans Iceland Loss of Heterozygosity Male Microsatellite Repeats Middle Aged Neoplasm Proteins Neoplasms Hormone-Dependent Polymerase Chain Reaction Progesterone Sequence Deletion Transcription Factors Huiping, C Johannsdottir, J T Arason, A Olafsdottir, G H Eiriksdottir, G Egilsson, V Ingvarsson, S Replication error in human breast cancer: comparison with clinical variables and family history of cancer. |
topic_facet |
Adult Age of Onset Aged 80 and over Aneuploidy BRCA2 Protein Breast Neoplasms Carcinoma Ductal Breast Chromosomes Human DNA Replication DNA Neoplasm Estrogens Family Health Female Heterozygote Humans Iceland Loss of Heterozygosity Male Microsatellite Repeats Middle Aged Neoplasm Proteins Neoplasms Hormone-Dependent Polymerase Chain Reaction Progesterone Sequence Deletion Transcription Factors |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Replication errors (RER) at microsatellite repeats indicate genomic instability in hereditary nonpolyposis colorectal cancer (HNPCC) and in some sporadic cancers. We have studied genomic instability in 313 sporadic breast tumors and in 106 tumors from BRCA2, 999del5 carriers at 43 genomic loci on 13 chromosomes. RER was observed in 8/419 (1.9%) of the cases at one or more chromosomal loci. The frequencies of type I and type II RER were similar. The majority of RER+ tumors showed ER+, PgR+, high S-phase fraction, tumor size >2 cm and LOH at 2p, 2q and 3p. All 8 RER+ tumors were of the ductal histotype. The breast cancer cases with RER are not part of an HNPCC syndrome and a family history of colorectal cancer growth is not detected in relatives, with the exception of one case. However, four of the RER+ cases are from individuals carrying the BRCA2, 999del5 mutation. We conclude that RER is a rare somatic event during human breast carcinogenesis and may be associated with progression of breast carcinomas. |
author2 |
Department of Pathology, University and National Hospital of Iceland, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Huiping, C Johannsdottir, J T Arason, A Olafsdottir, G H Eiriksdottir, G Egilsson, V Ingvarsson, S |
author_facet |
Huiping, C Johannsdottir, J T Arason, A Olafsdottir, G H Eiriksdottir, G Egilsson, V Ingvarsson, S |
author_sort |
Huiping, C |
title |
Replication error in human breast cancer: comparison with clinical variables and family history of cancer. |
title_short |
Replication error in human breast cancer: comparison with clinical variables and family history of cancer. |
title_full |
Replication error in human breast cancer: comparison with clinical variables and family history of cancer. |
title_fullStr |
Replication error in human breast cancer: comparison with clinical variables and family history of cancer. |
title_full_unstemmed |
Replication error in human breast cancer: comparison with clinical variables and family history of cancer. |
title_sort |
replication error in human breast cancer: comparison with clinical variables and family history of cancer. |
publisher |
D.A. Spandidos |
publishDate |
2011 |
url |
http://hdl.handle.net/2336/118946 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.spandidos-publications.com/or/ Oncol. Rep. 1999, 6(1):117-22 1021-335X 9864413 http://hdl.handle.net/2336/118946 Oncology reports |
_version_ |
1766041312623067136 |