Colon cancer in Iceland - a nationwide comparative study on various pathology parameters with respect to right and left tumor location and patients age.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Increasing evidence suggests genetic, biological and demographical difference between right and left colon cancer. Studies have also indicated age differences in the pathology of colon canc...
Published in: | International Journal of Cancer |
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Online Access: | http://hdl.handle.net/2336/116320 https://doi.org/10.1002/ijc.25258 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/116320 2023-05-15T16:47:43+02:00 Colon cancer in Iceland - a nationwide comparative study on various pathology parameters with respect to right and left tumor location and patients age. Snaebjornsson, Petur Jonasson, Larus Jonsson, Thorvaldur Möller, Pall Helgi Theodors, Asgeir Jonasson, Jon G Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 2010-11-25 http://hdl.handle.net/2336/116320 https://doi.org/10.1002/ijc.25258 en eng Wiley-Liss http://dx.doi.org/10.1002/ijc.25258 Int. J. Cancer. 2010, 127(11):2645-53 1097-0215 20162576 doi:10.1002/ijc.25258 http://hdl.handle.net/2336/116320 International journal of cancer. Journal international du cancer Adolescent Adult Age Factors Aged 80 and over Colonic Neoplasms Female Humans Iceland Male Middle Aged Neoplasm Staging Retrospective Studies Young Adult Article 2010 ftlandspitaliuni https://doi.org/10.1002/ijc.25258 2022-05-29T08:21:39Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Increasing evidence suggests genetic, biological and demographical difference between right and left colon cancer. Studies have also indicated age differences in the pathology of colon cancer. There is a scarcity of large-scale studies that closely examine the pathological differences regarding age and tumor location. The aim of our study was to do an extensive comparison of right- and left- sided colon cancers as well as comparing patients <50 years with older patients. A retrospective, population-based study was carried out on all patients with colon cancer in Iceland between 1955 and 2004. A total of 2293 cases were analyzed (1148 men, 1145 women). All histopathology material was re-evaluated. Differences in tumor characteristics between right and left location and younger (<50) and older (≥50) patients was evaluated in particular. Higher TNM-stage, larger tumors, vessel invasion, mucinous type, high grade and expanding tumor border occurred more frequently in right- versus left-sided lesions while annular and polypoid tumors were more common in left-sided tumors (p < 0.05). Young patients had more frequent lymph node metastases, vessel invasion, nonpolypoid lesions and infiltrating tumor border (p < 0.05). Right-sided lesions show more aggressive features, reflected in morphology and stage. Younger patients present more frequently with adverse features than do older patients. Frequency of right- and left-sided colon cancer differs by age with pronounced age-location differences in females. This supports the assumption of differences in etiology and carcinogenesis of right- and left-sided colon cancer, and between young and old patients. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive TNM ENVELOPE(-58.100,-58.100,-62.000,-62.000) International Journal of Cancer 127 11 2645 2653 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adolescent Adult Age Factors Aged 80 and over Colonic Neoplasms Female Humans Iceland Male Middle Aged Neoplasm Staging Retrospective Studies Young Adult |
spellingShingle |
Adolescent Adult Age Factors Aged 80 and over Colonic Neoplasms Female Humans Iceland Male Middle Aged Neoplasm Staging Retrospective Studies Young Adult Snaebjornsson, Petur Jonasson, Larus Jonsson, Thorvaldur Möller, Pall Helgi Theodors, Asgeir Jonasson, Jon G Colon cancer in Iceland - a nationwide comparative study on various pathology parameters with respect to right and left tumor location and patients age. |
topic_facet |
Adolescent Adult Age Factors Aged 80 and over Colonic Neoplasms Female Humans Iceland Male Middle Aged Neoplasm Staging Retrospective Studies Young Adult |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Increasing evidence suggests genetic, biological and demographical difference between right and left colon cancer. Studies have also indicated age differences in the pathology of colon cancer. There is a scarcity of large-scale studies that closely examine the pathological differences regarding age and tumor location. The aim of our study was to do an extensive comparison of right- and left- sided colon cancers as well as comparing patients <50 years with older patients. A retrospective, population-based study was carried out on all patients with colon cancer in Iceland between 1955 and 2004. A total of 2293 cases were analyzed (1148 men, 1145 women). All histopathology material was re-evaluated. Differences in tumor characteristics between right and left location and younger (<50) and older (≥50) patients was evaluated in particular. Higher TNM-stage, larger tumors, vessel invasion, mucinous type, high grade and expanding tumor border occurred more frequently in right- versus left-sided lesions while annular and polypoid tumors were more common in left-sided tumors (p < 0.05). Young patients had more frequent lymph node metastases, vessel invasion, nonpolypoid lesions and infiltrating tumor border (p < 0.05). Right-sided lesions show more aggressive features, reflected in morphology and stage. Younger patients present more frequently with adverse features than do older patients. Frequency of right- and left-sided colon cancer differs by age with pronounced age-location differences in females. This supports the assumption of differences in etiology and carcinogenesis of right- and left-sided colon cancer, and between young and old patients. |
author2 |
Faculty of Medicine, University of Iceland, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Snaebjornsson, Petur Jonasson, Larus Jonsson, Thorvaldur Möller, Pall Helgi Theodors, Asgeir Jonasson, Jon G |
author_facet |
Snaebjornsson, Petur Jonasson, Larus Jonsson, Thorvaldur Möller, Pall Helgi Theodors, Asgeir Jonasson, Jon G |
author_sort |
Snaebjornsson, Petur |
title |
Colon cancer in Iceland - a nationwide comparative study on various pathology parameters with respect to right and left tumor location and patients age. |
title_short |
Colon cancer in Iceland - a nationwide comparative study on various pathology parameters with respect to right and left tumor location and patients age. |
title_full |
Colon cancer in Iceland - a nationwide comparative study on various pathology parameters with respect to right and left tumor location and patients age. |
title_fullStr |
Colon cancer in Iceland - a nationwide comparative study on various pathology parameters with respect to right and left tumor location and patients age. |
title_full_unstemmed |
Colon cancer in Iceland - a nationwide comparative study on various pathology parameters with respect to right and left tumor location and patients age. |
title_sort |
colon cancer in iceland - a nationwide comparative study on various pathology parameters with respect to right and left tumor location and patients age. |
publisher |
Wiley-Liss |
publishDate |
2010 |
url |
http://hdl.handle.net/2336/116320 https://doi.org/10.1002/ijc.25258 |
long_lat |
ENVELOPE(-58.100,-58.100,-62.000,-62.000) |
geographic |
TNM |
geographic_facet |
TNM |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1002/ijc.25258 Int. J. Cancer. 2010, 127(11):2645-53 1097-0215 20162576 doi:10.1002/ijc.25258 http://hdl.handle.net/2336/116320 International journal of cancer. Journal international du cancer |
op_doi |
https://doi.org/10.1002/ijc.25258 |
container_title |
International Journal of Cancer |
container_volume |
127 |
container_issue |
11 |
container_start_page |
2645 |
op_container_end_page |
2653 |
_version_ |
1766037811356499968 |