A population-based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field From July 1984 the five Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) have registered all children with acute myeloid leukaemia (AML) and treated them on two consecutive p...
Published in: | British Journal of Haematology |
---|---|
Main Authors: | , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley-Blackwell
2010
|
Subjects: | |
Online Access: | http://hdl.handle.net/2336/115564 https://doi.org/10.1046/j.1365-2141.1996.d01-1761.x |
id |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/115564 |
---|---|
record_format |
openpolar |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/115564 2023-05-15T16:51:28+02:00 A population-based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome. Lie, S O Jonmundsson, G Mellander, L Siimes, M A Yssing, M Gustafsson, G Department of Paediatrics, National Hospital of Norway, Oslo, Norway. 2010-11-15 http://hdl.handle.net/2336/115564 https://doi.org/10.1046/j.1365-2141.1996.d01-1761.x en eng Wiley-Blackwell http://dx.doi.org/10.1046/j.1365-2141.1996.d01-1761.x Br. J. Haematol. 1996, 94(1):82-8 0007-1048 8757513 doi:10.1046/j.1365-2141.1996.d01-1761.x http://hdl.handle.net/2336/115564 British journal of haematology Adolescent Age of Onset Antineoplastic Combined Chemotherapy Protocols Bone Marrow Transplantation Child Preschool Disease-Free Survival Down Syndrome Female Humans Infant Newborn Leukemia Myeloid Male Population Surveillance Scandinavia Treatment Outcome Article 2010 ftlandspitaliuni https://doi.org/10.1046/j.1365-2141.1996.d01-1761.x 2022-05-29T08:21:39Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field From July 1984 the five Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) have registered all children with acute myeloid leukaemia (AML) and treated them on two consecutive protocols of different intensity (NOPHO-84 and NOPHO-88). We probably have information on every child with this diagnosis in our region. We found an annual incidence of AML of 0.7 new cases per 100,000 children < 16 years of age. We observed a distinct peak of incidence in the first 2 years of life. Children with Down's syndrome accounted for 13% of all cases. Eighty of 105 cases treated on NOPHO-84 achieved remission (78%). In NOPHO-88, 100/118 patients entered remission (85%). The overall event-free survival (p-EFS) for the two studies was 0.32 for NOPHO-84 and 0.42 for NOPHO-88. The majority of relapses occurred within 2 years of diagnosis. When looking for prognostic factors the strongest significant adverse factor found was male sex. Children with Down's syndrome (n = 35) had a very favourable outcome if they received therapy according to protocol, and infants (n = 26) had a superior outcome compared to children 1-2 years or > 10 years of age at diagnosis. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Norway British Journal of Haematology 94 1 82 88 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adolescent Age of Onset Antineoplastic Combined Chemotherapy Protocols Bone Marrow Transplantation Child Preschool Disease-Free Survival Down Syndrome Female Humans Infant Newborn Leukemia Myeloid Male Population Surveillance Scandinavia Treatment Outcome |
spellingShingle |
Adolescent Age of Onset Antineoplastic Combined Chemotherapy Protocols Bone Marrow Transplantation Child Preschool Disease-Free Survival Down Syndrome Female Humans Infant Newborn Leukemia Myeloid Male Population Surveillance Scandinavia Treatment Outcome Lie, S O Jonmundsson, G Mellander, L Siimes, M A Yssing, M Gustafsson, G A population-based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome. |
topic_facet |
Adolescent Age of Onset Antineoplastic Combined Chemotherapy Protocols Bone Marrow Transplantation Child Preschool Disease-Free Survival Down Syndrome Female Humans Infant Newborn Leukemia Myeloid Male Population Surveillance Scandinavia Treatment Outcome |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field From July 1984 the five Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) have registered all children with acute myeloid leukaemia (AML) and treated them on two consecutive protocols of different intensity (NOPHO-84 and NOPHO-88). We probably have information on every child with this diagnosis in our region. We found an annual incidence of AML of 0.7 new cases per 100,000 children < 16 years of age. We observed a distinct peak of incidence in the first 2 years of life. Children with Down's syndrome accounted for 13% of all cases. Eighty of 105 cases treated on NOPHO-84 achieved remission (78%). In NOPHO-88, 100/118 patients entered remission (85%). The overall event-free survival (p-EFS) for the two studies was 0.32 for NOPHO-84 and 0.42 for NOPHO-88. The majority of relapses occurred within 2 years of diagnosis. When looking for prognostic factors the strongest significant adverse factor found was male sex. Children with Down's syndrome (n = 35) had a very favourable outcome if they received therapy according to protocol, and infants (n = 26) had a superior outcome compared to children 1-2 years or > 10 years of age at diagnosis. |
author2 |
Department of Paediatrics, National Hospital of Norway, Oslo, Norway. |
format |
Article in Journal/Newspaper |
author |
Lie, S O Jonmundsson, G Mellander, L Siimes, M A Yssing, M Gustafsson, G |
author_facet |
Lie, S O Jonmundsson, G Mellander, L Siimes, M A Yssing, M Gustafsson, G |
author_sort |
Lie, S O |
title |
A population-based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome. |
title_short |
A population-based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome. |
title_full |
A population-based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome. |
title_fullStr |
A population-based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome. |
title_full_unstemmed |
A population-based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome. |
title_sort |
population-based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with down's syndrome. |
publisher |
Wiley-Blackwell |
publishDate |
2010 |
url |
http://hdl.handle.net/2336/115564 https://doi.org/10.1046/j.1365-2141.1996.d01-1761.x |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1046/j.1365-2141.1996.d01-1761.x Br. J. Haematol. 1996, 94(1):82-8 0007-1048 8757513 doi:10.1046/j.1365-2141.1996.d01-1761.x http://hdl.handle.net/2336/115564 British journal of haematology |
op_doi |
https://doi.org/10.1046/j.1365-2141.1996.d01-1761.x |
container_title |
British Journal of Haematology |
container_volume |
94 |
container_issue |
1 |
container_start_page |
82 |
op_container_end_page |
88 |
_version_ |
1766041578430791680 |