Dyslipoproteinaemia in postmenopausal women with a history of eclampsia
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To test the hypothesis that postmenopausal women with a history of eclampsia manifest a more high risk lipid profile than postmenopausal women with a history of normal pregnancy....
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Online Access: | http://hdl.handle.net/2336/115234 https://doi.org/10.1111/j.1471-0528.2000.tb13340.x |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/115234 2023-05-15T16:51:49+02:00 Dyslipoproteinaemia in postmenopausal women with a history of eclampsia Hubel, C A Snaedal, S Ness, R B Weissfeld, L A Geirsson, R T Roberts, J M Arngrimsson, R Department of Obstetrics and Gynaecology, University of Pittsburgh, USA. 2010-11-10 http://hdl.handle.net/2336/115234 https://doi.org/10.1111/j.1471-0528.2000.tb13340.x en eng Wiley-Blackwell http://dx.doi.org/10.1111/j.1471-0528.2000.tb13340.x BJOG. 2000, 107(6):776-84 1470-0328 10847235 doi:10.1111/j.1471-0528.2000.tb13340.x http://hdl.handle.net/2336/115234 BJOG : an international journal of obstetrics and gynaecology Aged Blood Glucose Cardiovascular Diseases Eclampsia Female Humans Hypolipoproteinemias Insulin Lipids Lipoproteins LDL Middle Aged Postmenopause Pregnancy Risk Factors Article 2010 ftlandspitaliuni https://doi.org/10.1111/j.1471-0528.2000.tb13340.x 2022-05-29T08:21:39Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To test the hypothesis that postmenopausal women with a history of eclampsia manifest a more high risk lipid profile than postmenopausal women with a history of normal pregnancy. SETTING: The Department of Obstetrics and Gynaecology, National University Hospital, Reykjavik, Iceland, and the Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA. PARTICIPANTS: Thirty Icelandic women with a history of eclampsia, aged between 50 and 67 years at the time of re-examination (cases) were individually matched for current age, and for age and parity at index pregnancy, to 30 unrelated Icelandic women with a history of normal pregnancy (controls). METHODS: The participating women completed a health and family history questionnaire and underwent a physical examination. Fasting plasma low density lipoprotein diameter, serum lipids, insulin, and glucose were measured. RESULTS: Mean low density lipoprotein size was significantly smaller and apolipoprotein B concentration was higher in women with prior eclampsia. The percentage of cases receiving blood pressure medication (33%) was significantly greater than controls (6.7%). Thirteen cases had had hypertensive complications in at least one other pregnancy (recurrent subgroup); postmenopausally, these women displayed significantly increased diastolic blood pressures, smaller-sized low density lipoprotein, increased apolipoprotein B, decreased high density lipoprotein2 (HDL2) cholesterol, and increased total cholesterol: HDL cholesterol ratio compared with their controls. Fourteen cases were normotensive in all other pregnancies (nonrecurrent); these showed no differences from their controls. CONCLUSIONS: Dyslipoproteinaemia is more prevalent among postmenopausal women with prior eclampsia, especially with recurrent hypertension in pregnancy, than in postmenopausal women with prior normal pregnancies. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive BJOG: An International Journal of Obstetrics and Gynaecology 107 6 776 784 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Aged Blood Glucose Cardiovascular Diseases Eclampsia Female Humans Hypolipoproteinemias Insulin Lipids Lipoproteins LDL Middle Aged Postmenopause Pregnancy Risk Factors |
spellingShingle |
Aged Blood Glucose Cardiovascular Diseases Eclampsia Female Humans Hypolipoproteinemias Insulin Lipids Lipoproteins LDL Middle Aged Postmenopause Pregnancy Risk Factors Hubel, C A Snaedal, S Ness, R B Weissfeld, L A Geirsson, R T Roberts, J M Arngrimsson, R Dyslipoproteinaemia in postmenopausal women with a history of eclampsia |
topic_facet |
Aged Blood Glucose Cardiovascular Diseases Eclampsia Female Humans Hypolipoproteinemias Insulin Lipids Lipoproteins LDL Middle Aged Postmenopause Pregnancy Risk Factors |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To test the hypothesis that postmenopausal women with a history of eclampsia manifest a more high risk lipid profile than postmenopausal women with a history of normal pregnancy. SETTING: The Department of Obstetrics and Gynaecology, National University Hospital, Reykjavik, Iceland, and the Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA. PARTICIPANTS: Thirty Icelandic women with a history of eclampsia, aged between 50 and 67 years at the time of re-examination (cases) were individually matched for current age, and for age and parity at index pregnancy, to 30 unrelated Icelandic women with a history of normal pregnancy (controls). METHODS: The participating women completed a health and family history questionnaire and underwent a physical examination. Fasting plasma low density lipoprotein diameter, serum lipids, insulin, and glucose were measured. RESULTS: Mean low density lipoprotein size was significantly smaller and apolipoprotein B concentration was higher in women with prior eclampsia. The percentage of cases receiving blood pressure medication (33%) was significantly greater than controls (6.7%). Thirteen cases had had hypertensive complications in at least one other pregnancy (recurrent subgroup); postmenopausally, these women displayed significantly increased diastolic blood pressures, smaller-sized low density lipoprotein, increased apolipoprotein B, decreased high density lipoprotein2 (HDL2) cholesterol, and increased total cholesterol: HDL cholesterol ratio compared with their controls. Fourteen cases were normotensive in all other pregnancies (nonrecurrent); these showed no differences from their controls. CONCLUSIONS: Dyslipoproteinaemia is more prevalent among postmenopausal women with prior eclampsia, especially with recurrent hypertension in pregnancy, than in postmenopausal women with prior normal pregnancies. |
author2 |
Department of Obstetrics and Gynaecology, University of Pittsburgh, USA. |
format |
Article in Journal/Newspaper |
author |
Hubel, C A Snaedal, S Ness, R B Weissfeld, L A Geirsson, R T Roberts, J M Arngrimsson, R |
author_facet |
Hubel, C A Snaedal, S Ness, R B Weissfeld, L A Geirsson, R T Roberts, J M Arngrimsson, R |
author_sort |
Hubel, C A |
title |
Dyslipoproteinaemia in postmenopausal women with a history of eclampsia |
title_short |
Dyslipoproteinaemia in postmenopausal women with a history of eclampsia |
title_full |
Dyslipoproteinaemia in postmenopausal women with a history of eclampsia |
title_fullStr |
Dyslipoproteinaemia in postmenopausal women with a history of eclampsia |
title_full_unstemmed |
Dyslipoproteinaemia in postmenopausal women with a history of eclampsia |
title_sort |
dyslipoproteinaemia in postmenopausal women with a history of eclampsia |
publisher |
Wiley-Blackwell |
publishDate |
2010 |
url |
http://hdl.handle.net/2336/115234 https://doi.org/10.1111/j.1471-0528.2000.tb13340.x |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1111/j.1471-0528.2000.tb13340.x BJOG. 2000, 107(6):776-84 1470-0328 10847235 doi:10.1111/j.1471-0528.2000.tb13340.x http://hdl.handle.net/2336/115234 BJOG : an international journal of obstetrics and gynaecology |
op_doi |
https://doi.org/10.1111/j.1471-0528.2000.tb13340.x |
container_title |
BJOG: An International Journal of Obstetrics and Gynaecology |
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107 |
container_issue |
6 |
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776 |
op_container_end_page |
784 |
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