Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: Diabetes increases the risk for microvascular disease. The retina and the brain both have intricate microvascular systems that are developmentally similar. We sought to examine w...
Published in: | Diabetes |
---|---|
Main Authors: | , , , , , , , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
American Diabetes Association
2010
|
Subjects: | |
Online Access: | http://hdl.handle.net/2336/113872 https://doi.org/10.2337/db07-1455 |
id |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/113872 |
---|---|
record_format |
openpolar |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/113872 2023-05-15T16:52:20+02:00 Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study Qiu, Chengxuan Cotch, Mary Frances Sigurdsson, Sigurdur Garcia, Melissa Klein, Ronald Jonasson, Fridbert Klein, Barbara E K Eiriksdottir, Gudny Harris, Tamara B van Buchem, Mark A Gudnason, Vilmundur Launer, Lenore J Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health (NIH), Bethesda, Maryland 20892, USA. 2010-10-22 http://hdl.handle.net/2336/113872 https://doi.org/10.2337/db07-1455 en eng American Diabetes Association http://dx.doi.org/10.2337/db07-1455 Diabetes. 2008, 57(6):1645-50 1939-327X 18332097 doi:10.2337/db07-1455 http://hdl.handle.net/2336/113872 Diabetes Aged 80 and over Arterioles Cerebral Hemorrhage Cerebrovascular Circulation Diabetes Mellitus Environment Female Genetic Predisposition to Disease Humans Iceland Magnetic Resonance Imaging Male Microcirculation Middle Aged Retina Retinal Vessels Venules Article 2010 ftlandspitaliuni https://doi.org/10.2337/db07-1455 2022-05-29T08:21:38Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: Diabetes increases the risk for microvascular disease. The retina and the brain both have intricate microvascular systems that are developmentally similar. We sought to examine whether microvascular lesions in the retina and in the brain are associated and whether this association differs among people with and without diabetes. RESEARCH DESIGN AND METHODS: The analysis included 4,218 participants of the Icelandic population-based Age, Gene/Environment Susceptibility-Reykjavik Study who were born in 1907-1935 and who were previously followed as a part of the Reykjavik Study. Retinal focal arteriolar narrowing, arteriovenous (AV) nicking, and microaneurysms/hemorrhages were evaluated on digital retinal images of both eyes. Cerebral microbleeds (CMBs) were evaluated from magnetic resonance images. Data were analyzed with logistic and multinomial logistic regression models controlling for demographics, major cardiovascular risk factors, cerebral infarcts, and white matter lesions. RESULTS: Evidence of brain microbleeds was found in 485 (11.5%) people, including 192 with multiple (>or=2) microbleeds. Subjects with signs of retinal microvascular lesions were at a significantly increased likelihood for having multiple CMBs. People with diabetes in combination with the presence of either retinal AV nicking (odds ratio [OR] 2.47 [95% CI 1.42-4.31]) or retinal microaneurysms/hemorrhages (2.28 [1.24-4.18]) were significantly more likely to have multiple CMBs. CONCLUSIONS: Retinal microvascular abnormalities and brain microbleeds may occur together in older adults. People with both diabetes and signs of retinal microvascular lesions (AV nicking and microaneurysms/hemorrhages) are more likely to have multiple microbleeds in the brain. Microvascular disease in diabetes extends to the brain. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Diabetes 57 6 1645 1650 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Aged 80 and over Arterioles Cerebral Hemorrhage Cerebrovascular Circulation Diabetes Mellitus Environment Female Genetic Predisposition to Disease Humans Iceland Magnetic Resonance Imaging Male Microcirculation Middle Aged Retina Retinal Vessels Venules |
spellingShingle |
Aged 80 and over Arterioles Cerebral Hemorrhage Cerebrovascular Circulation Diabetes Mellitus Environment Female Genetic Predisposition to Disease Humans Iceland Magnetic Resonance Imaging Male Microcirculation Middle Aged Retina Retinal Vessels Venules Qiu, Chengxuan Cotch, Mary Frances Sigurdsson, Sigurdur Garcia, Melissa Klein, Ronald Jonasson, Fridbert Klein, Barbara E K Eiriksdottir, Gudny Harris, Tamara B van Buchem, Mark A Gudnason, Vilmundur Launer, Lenore J Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study |
topic_facet |
Aged 80 and over Arterioles Cerebral Hemorrhage Cerebrovascular Circulation Diabetes Mellitus Environment Female Genetic Predisposition to Disease Humans Iceland Magnetic Resonance Imaging Male Microcirculation Middle Aged Retina Retinal Vessels Venules |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: Diabetes increases the risk for microvascular disease. The retina and the brain both have intricate microvascular systems that are developmentally similar. We sought to examine whether microvascular lesions in the retina and in the brain are associated and whether this association differs among people with and without diabetes. RESEARCH DESIGN AND METHODS: The analysis included 4,218 participants of the Icelandic population-based Age, Gene/Environment Susceptibility-Reykjavik Study who were born in 1907-1935 and who were previously followed as a part of the Reykjavik Study. Retinal focal arteriolar narrowing, arteriovenous (AV) nicking, and microaneurysms/hemorrhages were evaluated on digital retinal images of both eyes. Cerebral microbleeds (CMBs) were evaluated from magnetic resonance images. Data were analyzed with logistic and multinomial logistic regression models controlling for demographics, major cardiovascular risk factors, cerebral infarcts, and white matter lesions. RESULTS: Evidence of brain microbleeds was found in 485 (11.5%) people, including 192 with multiple (>or=2) microbleeds. Subjects with signs of retinal microvascular lesions were at a significantly increased likelihood for having multiple CMBs. People with diabetes in combination with the presence of either retinal AV nicking (odds ratio [OR] 2.47 [95% CI 1.42-4.31]) or retinal microaneurysms/hemorrhages (2.28 [1.24-4.18]) were significantly more likely to have multiple CMBs. CONCLUSIONS: Retinal microvascular abnormalities and brain microbleeds may occur together in older adults. People with both diabetes and signs of retinal microvascular lesions (AV nicking and microaneurysms/hemorrhages) are more likely to have multiple microbleeds in the brain. Microvascular disease in diabetes extends to the brain. |
author2 |
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health (NIH), Bethesda, Maryland 20892, USA. |
format |
Article in Journal/Newspaper |
author |
Qiu, Chengxuan Cotch, Mary Frances Sigurdsson, Sigurdur Garcia, Melissa Klein, Ronald Jonasson, Fridbert Klein, Barbara E K Eiriksdottir, Gudny Harris, Tamara B van Buchem, Mark A Gudnason, Vilmundur Launer, Lenore J |
author_facet |
Qiu, Chengxuan Cotch, Mary Frances Sigurdsson, Sigurdur Garcia, Melissa Klein, Ronald Jonasson, Fridbert Klein, Barbara E K Eiriksdottir, Gudny Harris, Tamara B van Buchem, Mark A Gudnason, Vilmundur Launer, Lenore J |
author_sort |
Qiu, Chengxuan |
title |
Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study |
title_short |
Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study |
title_full |
Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study |
title_fullStr |
Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study |
title_full_unstemmed |
Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study |
title_sort |
retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-reykjavik study |
publisher |
American Diabetes Association |
publishDate |
2010 |
url |
http://hdl.handle.net/2336/113872 https://doi.org/10.2337/db07-1455 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.2337/db07-1455 Diabetes. 2008, 57(6):1645-50 1939-327X 18332097 doi:10.2337/db07-1455 http://hdl.handle.net/2336/113872 Diabetes |
op_doi |
https://doi.org/10.2337/db07-1455 |
container_title |
Diabetes |
container_volume |
57 |
container_issue |
6 |
container_start_page |
1645 |
op_container_end_page |
1650 |
_version_ |
1766042490431864832 |