Familiality of kidney stone disease in Iceland.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE:The aetiology of kidney stones is multifactorial, with environmental and genetic factors contributing to the pathogenesis. The aim of this study was to assess the role of genetic...
Published in: | Scandinavian Journal of Urology and Nephrology |
---|---|
Main Authors: | , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2010
|
Subjects: | |
Online Access: | http://hdl.handle.net/2336/112669 https://doi.org/10.3109/00365590903151479 |
id |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/112669 |
---|---|
record_format |
openpolar |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/112669 2023-05-15T16:46:44+02:00 Familiality of kidney stone disease in Iceland. Edvardsson, V O Palsson, R Indridason, O S Thorvaldsson, S Stefansson, K Children's Medical Center, Landspitali University Hospital, Reykjavik, Iceland. 2010-10-08 http://hdl.handle.net/2336/112669 https://doi.org/10.3109/00365590903151479 en eng http://dx.doi.org/10.3109/00365590903151479 Scand. J. Urol. Nephrol. 2009, 43(5):420-4 1651-2065 19921989 doi:10.3109/00365590903151479 http://hdl.handle.net/2336/112669 Scandinavian journal of urology and nephrology Female Genetic Predisposition to Disease Humans Iceland Kidney Calculi Male Middle Aged Pedigree Prevalence Prognosis Recurrence Retrospective Studies Risk Assessment Risk Factors Article 2010 ftlandspitaliuni https://doi.org/10.3109/00365590903151479 2022-05-29T08:21:38Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE:The aetiology of kidney stones is multifactorial, with environmental and genetic factors contributing to the pathogenesis. The aim of this study was to assess the role of genetic factors in kidney stone disease by examining the heritability of the trait in Icelandic patients. MATERIAL AND METHODS: Medical records at all major hospitals and imaging centres in Iceland were searched for diagnostic codes indicative of kidney stones, yielding a cohort of 5954 incident patients with kidney stone disease. The list of patients was cross-matched with a genealogy database that covers the entire Icelandic nation. The risk ratio (RR) and kinship coefficient (KC) were calculated to determine the risk of kidney stones in relatives of stone formers and the relatedness among kidney stone patients. RESULTS: The risk of kidney stones among family members of stone formers was significantly higher than in the general population. In 2959 patients with radiopaque stones, the RR ranged from 2.25 (p<0.001) for first degree relatives of probands (such as parents or siblings) to 1.07 (p<0.01) in fifth degree relatives. Moreover, for confirmed recurrent stone formers the RR of kidney stones in parents and offspring was in excess of 10 (p<0.001). The KC analysis shows that Icelandic patients with kidney stone disease are significantly more related to each other than is the average Icelander, even when considering only relatives separated by four meioses or more (p<0.05). CONCLUSIONS: The results suggest that genetic factors may substantially influence the risk of kidney stone disease in Iceland. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Scandinavian Journal of Urology and Nephrology 43 5 420 424 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Female Genetic Predisposition to Disease Humans Iceland Kidney Calculi Male Middle Aged Pedigree Prevalence Prognosis Recurrence Retrospective Studies Risk Assessment Risk Factors |
spellingShingle |
Female Genetic Predisposition to Disease Humans Iceland Kidney Calculi Male Middle Aged Pedigree Prevalence Prognosis Recurrence Retrospective Studies Risk Assessment Risk Factors Edvardsson, V O Palsson, R Indridason, O S Thorvaldsson, S Stefansson, K Familiality of kidney stone disease in Iceland. |
topic_facet |
Female Genetic Predisposition to Disease Humans Iceland Kidney Calculi Male Middle Aged Pedigree Prevalence Prognosis Recurrence Retrospective Studies Risk Assessment Risk Factors |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE:The aetiology of kidney stones is multifactorial, with environmental and genetic factors contributing to the pathogenesis. The aim of this study was to assess the role of genetic factors in kidney stone disease by examining the heritability of the trait in Icelandic patients. MATERIAL AND METHODS: Medical records at all major hospitals and imaging centres in Iceland were searched for diagnostic codes indicative of kidney stones, yielding a cohort of 5954 incident patients with kidney stone disease. The list of patients was cross-matched with a genealogy database that covers the entire Icelandic nation. The risk ratio (RR) and kinship coefficient (KC) were calculated to determine the risk of kidney stones in relatives of stone formers and the relatedness among kidney stone patients. RESULTS: The risk of kidney stones among family members of stone formers was significantly higher than in the general population. In 2959 patients with radiopaque stones, the RR ranged from 2.25 (p<0.001) for first degree relatives of probands (such as parents or siblings) to 1.07 (p<0.01) in fifth degree relatives. Moreover, for confirmed recurrent stone formers the RR of kidney stones in parents and offspring was in excess of 10 (p<0.001). The KC analysis shows that Icelandic patients with kidney stone disease are significantly more related to each other than is the average Icelander, even when considering only relatives separated by four meioses or more (p<0.05). CONCLUSIONS: The results suggest that genetic factors may substantially influence the risk of kidney stone disease in Iceland. |
author2 |
Children's Medical Center, Landspitali University Hospital, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Edvardsson, V O Palsson, R Indridason, O S Thorvaldsson, S Stefansson, K |
author_facet |
Edvardsson, V O Palsson, R Indridason, O S Thorvaldsson, S Stefansson, K |
author_sort |
Edvardsson, V O |
title |
Familiality of kidney stone disease in Iceland. |
title_short |
Familiality of kidney stone disease in Iceland. |
title_full |
Familiality of kidney stone disease in Iceland. |
title_fullStr |
Familiality of kidney stone disease in Iceland. |
title_full_unstemmed |
Familiality of kidney stone disease in Iceland. |
title_sort |
familiality of kidney stone disease in iceland. |
publishDate |
2010 |
url |
http://hdl.handle.net/2336/112669 https://doi.org/10.3109/00365590903151479 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.3109/00365590903151479 Scand. J. Urol. Nephrol. 2009, 43(5):420-4 1651-2065 19921989 doi:10.3109/00365590903151479 http://hdl.handle.net/2336/112669 Scandinavian journal of urology and nephrology |
op_doi |
https://doi.org/10.3109/00365590903151479 |
container_title |
Scandinavian Journal of Urology and Nephrology |
container_volume |
43 |
container_issue |
5 |
container_start_page |
420 |
op_container_end_page |
424 |
_version_ |
1766036834398240768 |