Silent ST-T changes in an epidemiologic cohort study--a marker of hypertension or coronary heart disease, or both: the Reykjavik study
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVES: We sought to evaluate the prognostic value and clinical characteristics associated with electrocardiographic (ECG) ST-T changes among men without other manifestations of coronar...
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/112255 2023-05-15T16:52:47+02:00 Silent ST-T changes in an epidemiologic cohort study--a marker of hypertension or coronary heart disease, or both: the Reykjavik study Sigurdsson, E Sigfusson, N Sigvaldason, H Thorgeirsson, G Icelandic Heart Association Heart Preventive Clinic, Reykjavik, Iceland. 2010-10-04 http://hdl.handle.net/2336/112255 https://doi.org/10.1016/0735-1097(95)00614-1 en eng Elsevier BV http://dx.doi.org/10.1016/0735-1097(95)00614-1 J. Am. Coll. Cardiol. 1996, 27(5):1140-7 0735-1097 8609333 doi:10.1016/0735-1097(95)00614-1 http://hdl.handle.net/2336/112255 Journal of the American College of Cardiology Age Factors Aged 80 and over Cohort Studies Coronary Disease Echocardiography Humans Hypertension Iceland Male Middle Aged Prognosis Risk Factors Article 2010 ftlandspitaliuni https://doi.org/10.1016/0735-1097(95)00614-1 2022-05-29T08:21:37Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVES: We sought to evaluate the prognostic value and clinical characteristics associated with electrocardiographic (ECG) ST-T changes among men without other manifestations of coronary heart disease. BACKGROUND: Recent achievements in secondary prevention and treatment of coronary heart disease have highlighted the importance of early diagnosis of both symptomatic and silent forms of the disease. The prognostic and clinical importance of ST-T changes in men with no other manifestations of coronary heart disease is still unclear. Do they reflect silent coronary heart disease or hypertension, or both, and what is their independent contribution to prognosis? METHODS: The subjects were 9,139 men born in the years 1907 to 1934 and followed up for 4 to 24 years. On initial visit they were assigned to different categories of coronary heart disease on the basis of Rose chest pain questionnaire, hospital records, 12-lead ECG, history and physical examination. RESULTS: The prevalence of silent ST-T changes among men without overt coronary heart disease was strongly influenced by age, increasing from 2% at age 40 years to 30% at age 80 years. Men with such ST-T changes were older and had higher serum triglyceride levels and worse glucose tolerance than men without such changes or other evidence of coronary heart disease. Their blood pressure was higher, and they more often had an enlarged heart or left ventricular hypertrophy and more often took antihypertensive medication, digitalis or diuretic drugs. Serum cholesterol levels were not different between the two groups. After adjustment for other risk factors, these silent ST-T changes had a risk ratio of 2.0 for death from coronary heart disease and 1.6 for subsequent myocardial infarction or angina pectoris. CONCLUSIONS: Silent ST-T changes that are ischemic by the Minnesota code are probably both a marker of silent coronary heart disease and high blood ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Journal of the American College of Cardiology 27 5 1140 1147 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Age Factors Aged 80 and over Cohort Studies Coronary Disease Echocardiography Humans Hypertension Iceland Male Middle Aged Prognosis Risk Factors |
spellingShingle |
Age Factors Aged 80 and over Cohort Studies Coronary Disease Echocardiography Humans Hypertension Iceland Male Middle Aged Prognosis Risk Factors Sigurdsson, E Sigfusson, N Sigvaldason, H Thorgeirsson, G Silent ST-T changes in an epidemiologic cohort study--a marker of hypertension or coronary heart disease, or both: the Reykjavik study |
topic_facet |
Age Factors Aged 80 and over Cohort Studies Coronary Disease Echocardiography Humans Hypertension Iceland Male Middle Aged Prognosis Risk Factors |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVES: We sought to evaluate the prognostic value and clinical characteristics associated with electrocardiographic (ECG) ST-T changes among men without other manifestations of coronary heart disease. BACKGROUND: Recent achievements in secondary prevention and treatment of coronary heart disease have highlighted the importance of early diagnosis of both symptomatic and silent forms of the disease. The prognostic and clinical importance of ST-T changes in men with no other manifestations of coronary heart disease is still unclear. Do they reflect silent coronary heart disease or hypertension, or both, and what is their independent contribution to prognosis? METHODS: The subjects were 9,139 men born in the years 1907 to 1934 and followed up for 4 to 24 years. On initial visit they were assigned to different categories of coronary heart disease on the basis of Rose chest pain questionnaire, hospital records, 12-lead ECG, history and physical examination. RESULTS: The prevalence of silent ST-T changes among men without overt coronary heart disease was strongly influenced by age, increasing from 2% at age 40 years to 30% at age 80 years. Men with such ST-T changes were older and had higher serum triglyceride levels and worse glucose tolerance than men without such changes or other evidence of coronary heart disease. Their blood pressure was higher, and they more often had an enlarged heart or left ventricular hypertrophy and more often took antihypertensive medication, digitalis or diuretic drugs. Serum cholesterol levels were not different between the two groups. After adjustment for other risk factors, these silent ST-T changes had a risk ratio of 2.0 for death from coronary heart disease and 1.6 for subsequent myocardial infarction or angina pectoris. CONCLUSIONS: Silent ST-T changes that are ischemic by the Minnesota code are probably both a marker of silent coronary heart disease and high blood ... |
author2 |
Icelandic Heart Association Heart Preventive Clinic, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Sigurdsson, E Sigfusson, N Sigvaldason, H Thorgeirsson, G |
author_facet |
Sigurdsson, E Sigfusson, N Sigvaldason, H Thorgeirsson, G |
author_sort |
Sigurdsson, E |
title |
Silent ST-T changes in an epidemiologic cohort study--a marker of hypertension or coronary heart disease, or both: the Reykjavik study |
title_short |
Silent ST-T changes in an epidemiologic cohort study--a marker of hypertension or coronary heart disease, or both: the Reykjavik study |
title_full |
Silent ST-T changes in an epidemiologic cohort study--a marker of hypertension or coronary heart disease, or both: the Reykjavik study |
title_fullStr |
Silent ST-T changes in an epidemiologic cohort study--a marker of hypertension or coronary heart disease, or both: the Reykjavik study |
title_full_unstemmed |
Silent ST-T changes in an epidemiologic cohort study--a marker of hypertension or coronary heart disease, or both: the Reykjavik study |
title_sort |
silent st-t changes in an epidemiologic cohort study--a marker of hypertension or coronary heart disease, or both: the reykjavik study |
publisher |
Elsevier BV |
publishDate |
2010 |
url |
http://hdl.handle.net/2336/112255 https://doi.org/10.1016/0735-1097(95)00614-1 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1016/0735-1097(95)00614-1 J. Am. Coll. Cardiol. 1996, 27(5):1140-7 0735-1097 8609333 doi:10.1016/0735-1097(95)00614-1 http://hdl.handle.net/2336/112255 Journal of the American College of Cardiology |
op_doi |
https://doi.org/10.1016/0735-1097(95)00614-1 |
container_title |
Journal of the American College of Cardiology |
container_volume |
27 |
container_issue |
5 |
container_start_page |
1140 |
op_container_end_page |
1147 |
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1766043182289649664 |