Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We searched for mutations in the CCK gene in panic disorder with single-strand conformational polymorphism (SSCP) analysis of the three exons and promotor region of the gene. We found a C--...
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/108541 2023-05-15T16:51:28+02:00 Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder Wang, Z Valdes, J Noyes, R Zoega, T Crowe, R R Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242-1000, USA. 2010-07-28 http://hdl.handle.net/2336/108541 https://doi.org/10.1002/(SICI)1096-8628(19980508)81:3<228::AID-AJMG5>3.0.CO;2-S en eng Wiley-Liss http://dx.doi.org/10.1002/(SICI)1096-8628(19980508)81:3<228::AID-AJMG5>3.0.CO;2-S Am. J. Med. Genet. 1998, 81(3):228-34 0148-7299 9603610 doi:10.1002/(SICI)1096-8628(19980508)81:3<228::AID-AJMG5>3.0.CO;2-S http://hdl.handle.net/2336/108541 American journal of medical genetics Adult Cholecystokinin DNA Mutational Analysis Exons Female Gene Frequency Humans Iceland Iowa Linkage (Genetics) Male Middle Aged Panic Disorder Pedigree Point Mutation Polymorphism Single-Stranded Conformational Promoter Regions Genetic Article 2010 ftlandspitaliuni https://doi.org/10.1002/(SICI)1096-8628(19980508)81:3<228::AID-AJMG5>3.0.CO;2-S 2022-05-29T08:21:34Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We searched for mutations in the CCK gene in panic disorder with single-strand conformational polymorphism (SSCP) analysis of the three exons and promotor region of the gene. We found a C-->T transition at position -36 (CCK(-36C-->T)) in a GC box, a binding site for transcription factor Sp1, in the promotor region. The allele frequency was 0.168 (95% CI, 0.116-0.221) in 98 persons with panic disorder and 0.083 (95% CI, 0.059-0.107) in 247 geographically matched, unscreened controls. A transmission disequilibrium test based on panic disorder as the affected phenotype was nonsignificant (chi2 = 0.93), but when panic disorder or attacks were considered as affected, statistically significant transmission disequilibrium was detected (chi2 = 4.00, P < 0.05). Linkage analysis was uninformative. In exploratory analyses to search for clinical correlations, the "T" allele was found in 59% of 22 persons with panic attacks but not panic disorder, compared with 31% of those who met the criteria for panic disorder. An association between the CCK polymorphism and panic disorder cannot be considered established due to the inconsistencies in the results noted above, but if the provisional association can be replicated, the findings are consistent with CCK(-36C-->T) being a disease-susceptibility allele that alone is neither necessary nor sufficient to cause panic disorder but that increases vulnerability by acting epistatically. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive |
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Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adult Cholecystokinin DNA Mutational Analysis Exons Female Gene Frequency Humans Iceland Iowa Linkage (Genetics) Male Middle Aged Panic Disorder Pedigree Point Mutation Polymorphism Single-Stranded Conformational Promoter Regions Genetic |
spellingShingle |
Adult Cholecystokinin DNA Mutational Analysis Exons Female Gene Frequency Humans Iceland Iowa Linkage (Genetics) Male Middle Aged Panic Disorder Pedigree Point Mutation Polymorphism Single-Stranded Conformational Promoter Regions Genetic Wang, Z Valdes, J Noyes, R Zoega, T Crowe, R R Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder |
topic_facet |
Adult Cholecystokinin DNA Mutational Analysis Exons Female Gene Frequency Humans Iceland Iowa Linkage (Genetics) Male Middle Aged Panic Disorder Pedigree Point Mutation Polymorphism Single-Stranded Conformational Promoter Regions Genetic |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We searched for mutations in the CCK gene in panic disorder with single-strand conformational polymorphism (SSCP) analysis of the three exons and promotor region of the gene. We found a C-->T transition at position -36 (CCK(-36C-->T)) in a GC box, a binding site for transcription factor Sp1, in the promotor region. The allele frequency was 0.168 (95% CI, 0.116-0.221) in 98 persons with panic disorder and 0.083 (95% CI, 0.059-0.107) in 247 geographically matched, unscreened controls. A transmission disequilibrium test based on panic disorder as the affected phenotype was nonsignificant (chi2 = 0.93), but when panic disorder or attacks were considered as affected, statistically significant transmission disequilibrium was detected (chi2 = 4.00, P < 0.05). Linkage analysis was uninformative. In exploratory analyses to search for clinical correlations, the "T" allele was found in 59% of 22 persons with panic attacks but not panic disorder, compared with 31% of those who met the criteria for panic disorder. An association between the CCK polymorphism and panic disorder cannot be considered established due to the inconsistencies in the results noted above, but if the provisional association can be replicated, the findings are consistent with CCK(-36C-->T) being a disease-susceptibility allele that alone is neither necessary nor sufficient to cause panic disorder but that increases vulnerability by acting epistatically. |
author2 |
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242-1000, USA. |
format |
Article in Journal/Newspaper |
author |
Wang, Z Valdes, J Noyes, R Zoega, T Crowe, R R |
author_facet |
Wang, Z Valdes, J Noyes, R Zoega, T Crowe, R R |
author_sort |
Wang, Z |
title |
Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder |
title_short |
Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder |
title_full |
Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder |
title_fullStr |
Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder |
title_full_unstemmed |
Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder |
title_sort |
possible association of a cholecystokinin promotor polymorphism (cck-36ct) with panic disorder |
publisher |
Wiley-Liss |
publishDate |
2010 |
url |
http://hdl.handle.net/2336/108541 https://doi.org/10.1002/(SICI)1096-8628(19980508)81:3<228::AID-AJMG5>3.0.CO;2-S |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1002/(SICI)1096-8628(19980508)81:3<228::AID-AJMG5>3.0.CO;2-S Am. J. Med. Genet. 1998, 81(3):228-34 0148-7299 9603610 doi:10.1002/(SICI)1096-8628(19980508)81:3<228::AID-AJMG5>3.0.CO;2-S http://hdl.handle.net/2336/108541 American journal of medical genetics |
op_doi |
https://doi.org/10.1002/(SICI)1096-8628(19980508)81:3<228::AID-AJMG5>3.0.CO;2-S |
_version_ |
1766041576997388288 |