The prevalence of the variants of the L-ficolin gene (FCN2) in the arctic populations of East Siberia

• Published in: Immunogenetics
• Main Authors: Smolnikova, Marina, Freydin, Maxim, Tereshchenko, Sergey
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2017
• Subjects: Circumpolar area; L-ficolin; East Siberia; Arctic; Taymyr; Dolgan-Nenets; nenets; Nganasan*; Siberia
• Online Access: https://kclpure.kcl.ac.uk/portal/en/publications/the-prevalence-of-the-variants-of-the-lficolin-gene-fcn2-in-the-arctic-populations-of-east-siberia(cf1d63ed-e719-49cb-b679-907291d4e98c).html; https://doi.org/10.1007/s00251-017-0984-8; https://kclpure.kcl.ac.uk/ws/files/69665699/Smolnikova_Revised_2_ST_3_MF.pdf

L-ficolin encoded by FCN2 gene is a crucial factor of defence against infection in humans. We studied the prevalence of the two common variants (rs17549193 and rs7851696) in aboriginal and alien populations of the Taymyr-Dolgan-Nenets region of Krasnoyarskiy Kray, East Siberia, Russia (Nenets, Dolgans, Nganasans, Russians). We found a decreased prevalence of the rs17549193*T allele in all aboriginal populations as compared to Russians. Also, its frequency was the lowest in the Nenets among the studied populations, while frequency of the rs7851696*T allele was increased in this population. The results suggest that the Arctic populations of East Siberia are characterised by specificity of genetic make-up responsible for the activity of L-ficolin. Clinical and epidemiological studies are required to discover if these genetic features correlate with the infant infectious morbidity in East Siberian populations.