Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to assoc...
Published in: | Nature Genetics |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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2010
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Online Access: | https://kclpure.kcl.ac.uk/portal/en/publications/genomewide-association-study-identifies-a-sequence-variant-within-the-dab2ip-gene-conferring-susceptibility-to-abdominal-aortic-aneurysm(67eae939-5a34-44c4-b0e5-1dd63750441d).html https://doi.org/10.1038/ng.622 |
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We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival. |
format |
Article in Journal/Newspaper |
author |
Gretarsdottir, Solveig Baas, Annette F. Thorleifsson, Gudmar Holm, Hilma den Heijer, Martin de Vries, Jean-Paul P. M. Kranendonk, Steef E. Zeebregts, Clark J. A. M. van Sterkenburg, Steven M. Geelkerken, Robert H. van Rij, Andre M. Williams, Michael J. A. Boll, Albert P. M. Kostic, Jelena P. Jonasdottir, Adalbjorg Jonasdottir, Aslaug Walters, G. Bragi Masson, Gisli Sulem, Patrick Saemundsdottir, Jona Mouy, Magali Magnusson, Kristinn P. Tromp, Gerard Elmore, James R. Sakalihasan, Natzi Limet, Raymond Defraigne, Jean-Olivier Ferrell, Robert E. Ronkainen, Antti Ruigrok, Ynte M. Wijmenga, Cisca Grobbee, Diederick E. Shah, Svati H. Granger, Christopher B. Quyyumi, Arshed A. Vaccarino, Viola Patel, Riyaz S. Zafari, A. Maziar Levey, Allan I. Austin, Harland Girelli, Domenico Pignatti, Pier Franco Olivieri, Oliviero Martinelli, Nicola Malerba, Giovanni Trabetti, Elisabetta Becker, Lewis C. Becker, Diane M. Reilly, Muredach P. Rader, Daniel J. |
spellingShingle |
Gretarsdottir, Solveig Baas, Annette F. Thorleifsson, Gudmar Holm, Hilma den Heijer, Martin de Vries, Jean-Paul P. M. Kranendonk, Steef E. Zeebregts, Clark J. A. M. van Sterkenburg, Steven M. Geelkerken, Robert H. van Rij, Andre M. Williams, Michael J. A. Boll, Albert P. M. Kostic, Jelena P. Jonasdottir, Adalbjorg Jonasdottir, Aslaug Walters, G. Bragi Masson, Gisli Sulem, Patrick Saemundsdottir, Jona Mouy, Magali Magnusson, Kristinn P. Tromp, Gerard Elmore, James R. Sakalihasan, Natzi Limet, Raymond Defraigne, Jean-Olivier Ferrell, Robert E. Ronkainen, Antti Ruigrok, Ynte M. Wijmenga, Cisca Grobbee, Diederick E. Shah, Svati H. Granger, Christopher B. Quyyumi, Arshed A. Vaccarino, Viola Patel, Riyaz S. Zafari, A. Maziar Levey, Allan I. Austin, Harland Girelli, Domenico Pignatti, Pier Franco Olivieri, Oliviero Martinelli, Nicola Malerba, Giovanni Trabetti, Elisabetta Becker, Lewis C. Becker, Diane M. Reilly, Muredach P. Rader, Daniel J. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm |
author_facet |
Gretarsdottir, Solveig Baas, Annette F. Thorleifsson, Gudmar Holm, Hilma den Heijer, Martin de Vries, Jean-Paul P. M. Kranendonk, Steef E. Zeebregts, Clark J. A. M. van Sterkenburg, Steven M. Geelkerken, Robert H. van Rij, Andre M. Williams, Michael J. A. Boll, Albert P. M. Kostic, Jelena P. Jonasdottir, Adalbjorg Jonasdottir, Aslaug Walters, G. Bragi Masson, Gisli Sulem, Patrick Saemundsdottir, Jona Mouy, Magali Magnusson, Kristinn P. Tromp, Gerard Elmore, James R. Sakalihasan, Natzi Limet, Raymond Defraigne, Jean-Olivier Ferrell, Robert E. Ronkainen, Antti Ruigrok, Ynte M. Wijmenga, Cisca Grobbee, Diederick E. Shah, Svati H. Granger, Christopher B. Quyyumi, Arshed A. Vaccarino, Viola Patel, Riyaz S. Zafari, A. Maziar Levey, Allan I. Austin, Harland Girelli, Domenico Pignatti, Pier Franco Olivieri, Oliviero Martinelli, Nicola Malerba, Giovanni Trabetti, Elisabetta Becker, Lewis C. Becker, Diane M. Reilly, Muredach P. Rader, Daniel J. |
author_sort |
Gretarsdottir, Solveig |
title |
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm |
title_short |
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm |
title_full |
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm |
title_fullStr |
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm |
title_full_unstemmed |
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm |
title_sort |
genome-wide association study identifies a sequence variant within the dab2ip gene conferring susceptibility to abdominal aortic aneurysm |
publishDate |
2010 |
url |
https://kclpure.kcl.ac.uk/portal/en/publications/genomewide-association-study-identifies-a-sequence-variant-within-the-dab2ip-gene-conferring-susceptibility-to-abdominal-aortic-aneurysm(67eae939-5a34-44c4-b0e5-1dd63750441d).html https://doi.org/10.1038/ng.622 |
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Iceland |
genre_facet |
Iceland |
op_source |
Gretarsdottir , S , Baas , A F , Thorleifsson , G , Holm , H , den Heijer , M , de Vries , J-P P M , Kranendonk , S E , Zeebregts , C J A M , van Sterkenburg , S M , Geelkerken , R H , van Rij , A M , Williams , M J A , Boll , A P M , Kostic , J P , Jonasdottir , A , Jonasdottir , A , Walters , G B , Masson , G , Sulem , P , Saemundsdottir , J , Mouy , M , Magnusson , K P , Tromp , G , Elmore , J R , Sakalihasan , N , Limet , R , Defraigne , J-O , Ferrell , R E , Ronkainen , A , Ruigrok , Y M , Wijmenga , C , Grobbee , D E , Shah , S H , Granger , C B , Quyyumi , A A , Vaccarino , V , Patel , R S , Zafari , A M , Levey , A I , Austin , H , Girelli , D , Pignatti , P F , Olivieri , O , Martinelli , N , Malerba , G , Trabetti , E , Becker , L C , Becker , D M , Reilly , M P , Rader , D J , Mueller , T , Dieplinger , B , Haltmayer , M , Urbonavicius , S , Lindblad , B , Gottsater , A , Gaetani , E , Pola , R , Wells , P , Rodger , M , Forgie , M , Langlois , N , Corral , J , Vicente , V , Fontcuberta , J , Espana , F , Grarup , N , Jorgensen , T , Witte , D R , Hansen , T , Pedersen , O , Aben , K K , de Graaf , J , Holewijn , S , Folkersen , L , Franco-Cereceda , A , Eriksson , P , Collier , D A , Stefansson , H , Steinthorsdottir , V , Rafnar , T , Valdimarsson , E M , Magnadottir , H B , Sveinbjornsdottir , S , Olafsson , I , Magnusson , M K , Palmason , R , Haraldsdottir , V , Andersen , K , Onundarson , P T , Thorgeirsson , G , Kiemeney , L A , Powell , J T , Carey , D J , Kuivaniemi , H , Lindholt , J S , Jones , G T , Kong , A , Blankensteijn , J D , Matthiasson , S E , Thorsteinsdottir , U & Stefansson , K 2010 , ' Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm ' , Nature Genetics , vol. 42 , no. 8 , pp. 692 - U71 . https://doi.org/10.1038/ng.622 |
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ftkingscollondon:oai:pure.atira.dk:publications/67eae939-5a34-44c4-b0e5-1dd63750441d 2023-05-15T16:49:47+02:00 Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm Gretarsdottir, Solveig Baas, Annette F. Thorleifsson, Gudmar Holm, Hilma den Heijer, Martin de Vries, Jean-Paul P. M. Kranendonk, Steef E. Zeebregts, Clark J. A. M. van Sterkenburg, Steven M. Geelkerken, Robert H. van Rij, Andre M. Williams, Michael J. A. Boll, Albert P. M. Kostic, Jelena P. Jonasdottir, Adalbjorg Jonasdottir, Aslaug Walters, G. Bragi Masson, Gisli Sulem, Patrick Saemundsdottir, Jona Mouy, Magali Magnusson, Kristinn P. Tromp, Gerard Elmore, James R. Sakalihasan, Natzi Limet, Raymond Defraigne, Jean-Olivier Ferrell, Robert E. Ronkainen, Antti Ruigrok, Ynte M. Wijmenga, Cisca Grobbee, Diederick E. Shah, Svati H. Granger, Christopher B. Quyyumi, Arshed A. Vaccarino, Viola Patel, Riyaz S. Zafari, A. Maziar Levey, Allan I. Austin, Harland Girelli, Domenico Pignatti, Pier Franco Olivieri, Oliviero Martinelli, Nicola Malerba, Giovanni Trabetti, Elisabetta Becker, Lewis C. Becker, Diane M. Reilly, Muredach P. Rader, Daniel J. 2010-08 https://kclpure.kcl.ac.uk/portal/en/publications/genomewide-association-study-identifies-a-sequence-variant-within-the-dab2ip-gene-conferring-susceptibility-to-abdominal-aortic-aneurysm(67eae939-5a34-44c4-b0e5-1dd63750441d).html https://doi.org/10.1038/ng.622 eng eng info:eu-repo/semantics/restrictedAccess Gretarsdottir , S , Baas , A F , Thorleifsson , G , Holm , H , den Heijer , M , de Vries , J-P P M , Kranendonk , S E , Zeebregts , C J A M , van Sterkenburg , S M , Geelkerken , R H , van Rij , A M , Williams , M J A , Boll , A P M , Kostic , J P , Jonasdottir , A , Jonasdottir , A , Walters , G B , Masson , G , Sulem , P , Saemundsdottir , J , Mouy , M , Magnusson , K P , Tromp , G , Elmore , J R , Sakalihasan , N , Limet , R , Defraigne , J-O , Ferrell , R E , Ronkainen , A , Ruigrok , Y M , Wijmenga , C , Grobbee , D E , Shah , S H , Granger , C B , Quyyumi , A A , Vaccarino , V , Patel , R S , Zafari , A M , Levey , A I , Austin , H , Girelli , D , Pignatti , P F , Olivieri , O , Martinelli , N , Malerba , G , Trabetti , E , Becker , L C , Becker , D M , Reilly , M P , Rader , D J , Mueller , T , Dieplinger , B , Haltmayer , M , Urbonavicius , S , Lindblad , B , Gottsater , A , Gaetani , E , Pola , R , Wells , P , Rodger , M , Forgie , M , Langlois , N , Corral , J , Vicente , V , Fontcuberta , J , Espana , F , Grarup , N , Jorgensen , T , Witte , D R , Hansen , T , Pedersen , O , Aben , K K , de Graaf , J , Holewijn , S , Folkersen , L , Franco-Cereceda , A , Eriksson , P , Collier , D A , Stefansson , H , Steinthorsdottir , V , Rafnar , T , Valdimarsson , E M , Magnadottir , H B , Sveinbjornsdottir , S , Olafsson , I , Magnusson , M K , Palmason , R , Haraldsdottir , V , Andersen , K , Onundarson , P T , Thorgeirsson , G , Kiemeney , L A , Powell , J T , Carey , D J , Kuivaniemi , H , Lindholt , J S , Jones , G T , Kong , A , Blankensteijn , J D , Matthiasson , S E , Thorsteinsdottir , U & Stefansson , K 2010 , ' Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm ' , Nature Genetics , vol. 42 , no. 8 , pp. 692 - U71 . https://doi.org/10.1038/ng.622 article 2010 ftkingscollondon https://doi.org/10.1038/ng.622 2022-10-14T10:03:59Z We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival. Article in Journal/Newspaper Iceland King's College, London: Research Portal Nature Genetics 42 8 692 697 |