Human physiological and metabolic responses to an attempted winter crossing of Antarctica:the effects of prolonged hypobaric hypoxia
An insufficient supply of oxygen to the tissues (hypoxia), as is experienced upon high-altitude exposure, elicits physiological acclimatization mechanisms alongside metabolic remodeling. Details of the integrative adaptive processes in response to chronic hypobaric hypoxic exposure remain to be suff...
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Online Access: | https://kclpure.kcl.ac.uk/portal/en/publications/dda28a72-d4ab-4efd-9b97-4b8032acaf88 https://doi.org/10.14814/phy2.13613 https://kclpure.kcl.ac.uk/ws/files/88835931/Human_physiological_and_metabolic_O_BRIEN_Published9March2018_GOLD_VoR_CC_BY_.pdf |
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ftkingscollondon:oai:kclpure.kcl.ac.uk:publications/dda28a72-d4ab-4efd-9b97-4b8032acaf88 2024-05-12T07:54:36+00:00 Human physiological and metabolic responses to an attempted winter crossing of Antarctica:the effects of prolonged hypobaric hypoxia O'Brien, Katie A Pollock, Ross D Stroud, Mike Lambert, Rob J Kumar, Alex Atkinson, Robert A Green, David A Anton-Solanas, Ana Edwards, Lindsay M Harridge, Steve D R 2018-03-09 application/pdf https://kclpure.kcl.ac.uk/portal/en/publications/dda28a72-d4ab-4efd-9b97-4b8032acaf88 https://doi.org/10.14814/phy2.13613 https://kclpure.kcl.ac.uk/ws/files/88835931/Human_physiological_and_metabolic_O_BRIEN_Published9March2018_GOLD_VoR_CC_BY_.pdf eng eng info:eu-repo/semantics/openAccess O'Brien , K A , Pollock , R D , Stroud , M , Lambert , R J , Kumar , A , Atkinson , R A , Green , D A , Anton-Solanas , A , Edwards , L M & Harridge , S D R 2018 , ' Human physiological and metabolic responses to an attempted winter crossing of Antarctica : the effects of prolonged hypobaric hypoxia ' , Physiology Reports , vol. 6 , no. 5 . https://doi.org/10.14814/phy2.13613 article 2018 ftkingscollondon https://doi.org/10.14814/phy2.13613 2024-04-17T14:48:15Z An insufficient supply of oxygen to the tissues (hypoxia), as is experienced upon high-altitude exposure, elicits physiological acclimatization mechanisms alongside metabolic remodeling. Details of the integrative adaptive processes in response to chronic hypobaric hypoxic exposure remain to be sufficiently investigated. In this small applied field study, subjects (n = 5, male, age 28-54 years) undertook a 40 week Antarctica expedition in the winter months, which included 24 weeks residing above 2500 m. Measurements taken pre- and postexpedition revealed alterations to glucose and fatty acid resonances within the serum metabolic profile, a 7.8 (±3.6)% increase in respiratory exchange ratio measured during incremental exercise (area under curve, P > 0.01, mean ± SD) and a 2.1(±0.8) % decrease in fat tissue (P < 0.05) postexpedition. This was accompanied by an 11.6 (±1.9) % increase (P > 0.001) in VO2max corrected to % lean mass postexpedition. In addition, spine bone mineral density and lung function measures were identified as novel parameters of interest. This study provides, an in-depth characterization of the responses to chronic hypobaric hypoxic exposure in one of the most hostile environments on Earth. Article in Journal/Newspaper Antarc* Antarctica King's College, London: Research Portal Physiological Reports 6 5 e13613 |
institution |
Open Polar |
collection |
King's College, London: Research Portal |
op_collection_id |
ftkingscollondon |
language |
English |
description |
An insufficient supply of oxygen to the tissues (hypoxia), as is experienced upon high-altitude exposure, elicits physiological acclimatization mechanisms alongside metabolic remodeling. Details of the integrative adaptive processes in response to chronic hypobaric hypoxic exposure remain to be sufficiently investigated. In this small applied field study, subjects (n = 5, male, age 28-54 years) undertook a 40 week Antarctica expedition in the winter months, which included 24 weeks residing above 2500 m. Measurements taken pre- and postexpedition revealed alterations to glucose and fatty acid resonances within the serum metabolic profile, a 7.8 (±3.6)% increase in respiratory exchange ratio measured during incremental exercise (area under curve, P > 0.01, mean ± SD) and a 2.1(±0.8) % decrease in fat tissue (P < 0.05) postexpedition. This was accompanied by an 11.6 (±1.9) % increase (P > 0.001) in VO2max corrected to % lean mass postexpedition. In addition, spine bone mineral density and lung function measures were identified as novel parameters of interest. This study provides, an in-depth characterization of the responses to chronic hypobaric hypoxic exposure in one of the most hostile environments on Earth. |
format |
Article in Journal/Newspaper |
author |
O'Brien, Katie A Pollock, Ross D Stroud, Mike Lambert, Rob J Kumar, Alex Atkinson, Robert A Green, David A Anton-Solanas, Ana Edwards, Lindsay M Harridge, Steve D R |
spellingShingle |
O'Brien, Katie A Pollock, Ross D Stroud, Mike Lambert, Rob J Kumar, Alex Atkinson, Robert A Green, David A Anton-Solanas, Ana Edwards, Lindsay M Harridge, Steve D R Human physiological and metabolic responses to an attempted winter crossing of Antarctica:the effects of prolonged hypobaric hypoxia |
author_facet |
O'Brien, Katie A Pollock, Ross D Stroud, Mike Lambert, Rob J Kumar, Alex Atkinson, Robert A Green, David A Anton-Solanas, Ana Edwards, Lindsay M Harridge, Steve D R |
author_sort |
O'Brien, Katie A |
title |
Human physiological and metabolic responses to an attempted winter crossing of Antarctica:the effects of prolonged hypobaric hypoxia |
title_short |
Human physiological and metabolic responses to an attempted winter crossing of Antarctica:the effects of prolonged hypobaric hypoxia |
title_full |
Human physiological and metabolic responses to an attempted winter crossing of Antarctica:the effects of prolonged hypobaric hypoxia |
title_fullStr |
Human physiological and metabolic responses to an attempted winter crossing of Antarctica:the effects of prolonged hypobaric hypoxia |
title_full_unstemmed |
Human physiological and metabolic responses to an attempted winter crossing of Antarctica:the effects of prolonged hypobaric hypoxia |
title_sort |
human physiological and metabolic responses to an attempted winter crossing of antarctica:the effects of prolonged hypobaric hypoxia |
publishDate |
2018 |
url |
https://kclpure.kcl.ac.uk/portal/en/publications/dda28a72-d4ab-4efd-9b97-4b8032acaf88 https://doi.org/10.14814/phy2.13613 https://kclpure.kcl.ac.uk/ws/files/88835931/Human_physiological_and_metabolic_O_BRIEN_Published9March2018_GOLD_VoR_CC_BY_.pdf |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
O'Brien , K A , Pollock , R D , Stroud , M , Lambert , R J , Kumar , A , Atkinson , R A , Green , D A , Anton-Solanas , A , Edwards , L M & Harridge , S D R 2018 , ' Human physiological and metabolic responses to an attempted winter crossing of Antarctica : the effects of prolonged hypobaric hypoxia ' , Physiology Reports , vol. 6 , no. 5 . https://doi.org/10.14814/phy2.13613 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.14814/phy2.13613 |
container_title |
Physiological Reports |
container_volume |
6 |
container_issue |
5 |
container_start_page |
e13613 |
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1798850755110633472 |