Antireflux surgery and risk of lung cancer by histological type in a multinational cohort study
Introduction: Airway micro-aspiration might contribute to the proposed associations between gastroesophageal reflux disease (GERD) and some lung diseases, including lung cancer. This study aimed to examine the hypothesis that antireflux surgery decreases the risk of small cell carcinoma, squamous ce...
Published in: | European Journal of Cancer |
---|---|
Main Authors: | , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2020
|
Subjects: | |
Online Access: | https://kclpure.kcl.ac.uk/portal/en/publications/9afcf50f-d234-4413-9c35-9a4297367618 https://doi.org/10.1016/j.ejca.2020.07.018 http://www.scopus.com/inward/record.url?scp=85089955558&partnerID=8YFLogxK |
id |
ftkingscollondon:oai:kclpure.kcl.ac.uk:publications/9afcf50f-d234-4413-9c35-9a4297367618 |
---|---|
record_format |
openpolar |
spelling |
ftkingscollondon:oai:kclpure.kcl.ac.uk:publications/9afcf50f-d234-4413-9c35-9a4297367618 2024-04-28T08:26:10+00:00 Antireflux surgery and risk of lung cancer by histological type in a multinational cohort study Yanes, Manar Santoni, Giola Maret-Ouda, John Ness-Jensen, Eivind Färkkilä, Martti Lynge, Elsebeth Nwaru, Bright Pukkala, Eero Romundstad, Pål Tryggvadóttir, Laufey von Euler-Chelpin, My Lagergren, Jesper 2020-10 https://kclpure.kcl.ac.uk/portal/en/publications/9afcf50f-d234-4413-9c35-9a4297367618 https://doi.org/10.1016/j.ejca.2020.07.018 http://www.scopus.com/inward/record.url?scp=85089955558&partnerID=8YFLogxK eng eng info:eu-repo/semantics/openAccess Yanes , M , Santoni , G , Maret-Ouda , J , Ness-Jensen , E , Färkkilä , M , Lynge , E , Nwaru , B , Pukkala , E , Romundstad , P , Tryggvadóttir , L , von Euler-Chelpin , M & Lagergren , J 2020 , ' Antireflux surgery and risk of lung cancer by histological type in a multinational cohort study ' , European Journal of Cancer , vol. 138 , pp. 80-88 . https://doi.org/10.1016/j.ejca.2020.07.018 Bronchus Fundoplication GERD GORD Neoplasm Nissen Pulmonary article 2020 ftkingscollondon https://doi.org/10.1016/j.ejca.2020.07.018 2024-04-03T14:44:49Z Introduction: Airway micro-aspiration might contribute to the proposed associations between gastroesophageal reflux disease (GERD) and some lung diseases, including lung cancer. This study aimed to examine the hypothesis that antireflux surgery decreases the risk of small cell carcinoma, squamous cell carcinoma and adenocarcinoma of the lung differently depending on their location in relation to micro-aspiration. Methods: Population-based cohort study including patients having undergone antireflux surgery during 1980–2014 in Denmark, Finland, Iceland, Norway or Sweden. Patients having undergone antireflux surgery were compared with two groups: 1) the corresponding background population, by calculating standardised incidence ratios (SIRs) with 95% confidence intervals (CIs) and 2) non-operated GERD-patients, by calculating hazard ratios (HRs) with 95% CIs using multivariable Cox regression with adjustment for sex, age, calendar period, country, chronic obstructive pulmonary disease and obesity diagnosis or type 2 diabetes. Results: Among all 812,617 GERD-patients, 46,996 (5.8%) had undergone antireflux surgery. The SIRs were statistically significantly decreased for small cell carcinoma (SIR = 0.57, 95% CI 0.41–0.77) and squamous cell carcinoma (SIR = 0.75, 95% CI 0.60–0.92), but not for adenocarcinoma of the lung (SIR = 0.90, 95% CI 0.76–1.06). The HRs were also below unity for small cell carcinoma (HR = 0.63, 95% CI 0.44–0.90) and squamous cell carcinoma (HR = 0.80, 95% CI 0.62–1.03), but not for adenocarcinoma of the lung (HR = 1.03, 95% CI 0.84–1.26). Analyses restricted to patients with objective GERD (reflux oesophagitis or Barrett's oesophagus) showed similar results. Conclusions: This all-Nordic study indicates that patients who undergo antireflux surgery are at decreased risk of small cell carcinoma and squamous cell carcinoma of the lung, but not of adenocarcinoma of the lung. Article in Journal/Newspaper Iceland King's College, London: Research Portal European Journal of Cancer 138 80 88 |
institution |
Open Polar |
collection |
King's College, London: Research Portal |
op_collection_id |
ftkingscollondon |
language |
English |
topic |
Bronchus Fundoplication GERD GORD Neoplasm Nissen Pulmonary |
spellingShingle |
Bronchus Fundoplication GERD GORD Neoplasm Nissen Pulmonary Yanes, Manar Santoni, Giola Maret-Ouda, John Ness-Jensen, Eivind Färkkilä, Martti Lynge, Elsebeth Nwaru, Bright Pukkala, Eero Romundstad, Pål Tryggvadóttir, Laufey von Euler-Chelpin, My Lagergren, Jesper Antireflux surgery and risk of lung cancer by histological type in a multinational cohort study |
topic_facet |
Bronchus Fundoplication GERD GORD Neoplasm Nissen Pulmonary |
description |
Introduction: Airway micro-aspiration might contribute to the proposed associations between gastroesophageal reflux disease (GERD) and some lung diseases, including lung cancer. This study aimed to examine the hypothesis that antireflux surgery decreases the risk of small cell carcinoma, squamous cell carcinoma and adenocarcinoma of the lung differently depending on their location in relation to micro-aspiration. Methods: Population-based cohort study including patients having undergone antireflux surgery during 1980–2014 in Denmark, Finland, Iceland, Norway or Sweden. Patients having undergone antireflux surgery were compared with two groups: 1) the corresponding background population, by calculating standardised incidence ratios (SIRs) with 95% confidence intervals (CIs) and 2) non-operated GERD-patients, by calculating hazard ratios (HRs) with 95% CIs using multivariable Cox regression with adjustment for sex, age, calendar period, country, chronic obstructive pulmonary disease and obesity diagnosis or type 2 diabetes. Results: Among all 812,617 GERD-patients, 46,996 (5.8%) had undergone antireflux surgery. The SIRs were statistically significantly decreased for small cell carcinoma (SIR = 0.57, 95% CI 0.41–0.77) and squamous cell carcinoma (SIR = 0.75, 95% CI 0.60–0.92), but not for adenocarcinoma of the lung (SIR = 0.90, 95% CI 0.76–1.06). The HRs were also below unity for small cell carcinoma (HR = 0.63, 95% CI 0.44–0.90) and squamous cell carcinoma (HR = 0.80, 95% CI 0.62–1.03), but not for adenocarcinoma of the lung (HR = 1.03, 95% CI 0.84–1.26). Analyses restricted to patients with objective GERD (reflux oesophagitis or Barrett's oesophagus) showed similar results. Conclusions: This all-Nordic study indicates that patients who undergo antireflux surgery are at decreased risk of small cell carcinoma and squamous cell carcinoma of the lung, but not of adenocarcinoma of the lung. |
format |
Article in Journal/Newspaper |
author |
Yanes, Manar Santoni, Giola Maret-Ouda, John Ness-Jensen, Eivind Färkkilä, Martti Lynge, Elsebeth Nwaru, Bright Pukkala, Eero Romundstad, Pål Tryggvadóttir, Laufey von Euler-Chelpin, My Lagergren, Jesper |
author_facet |
Yanes, Manar Santoni, Giola Maret-Ouda, John Ness-Jensen, Eivind Färkkilä, Martti Lynge, Elsebeth Nwaru, Bright Pukkala, Eero Romundstad, Pål Tryggvadóttir, Laufey von Euler-Chelpin, My Lagergren, Jesper |
author_sort |
Yanes, Manar |
title |
Antireflux surgery and risk of lung cancer by histological type in a multinational cohort study |
title_short |
Antireflux surgery and risk of lung cancer by histological type in a multinational cohort study |
title_full |
Antireflux surgery and risk of lung cancer by histological type in a multinational cohort study |
title_fullStr |
Antireflux surgery and risk of lung cancer by histological type in a multinational cohort study |
title_full_unstemmed |
Antireflux surgery and risk of lung cancer by histological type in a multinational cohort study |
title_sort |
antireflux surgery and risk of lung cancer by histological type in a multinational cohort study |
publishDate |
2020 |
url |
https://kclpure.kcl.ac.uk/portal/en/publications/9afcf50f-d234-4413-9c35-9a4297367618 https://doi.org/10.1016/j.ejca.2020.07.018 http://www.scopus.com/inward/record.url?scp=85089955558&partnerID=8YFLogxK |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Yanes , M , Santoni , G , Maret-Ouda , J , Ness-Jensen , E , Färkkilä , M , Lynge , E , Nwaru , B , Pukkala , E , Romundstad , P , Tryggvadóttir , L , von Euler-Chelpin , M & Lagergren , J 2020 , ' Antireflux surgery and risk of lung cancer by histological type in a multinational cohort study ' , European Journal of Cancer , vol. 138 , pp. 80-88 . https://doi.org/10.1016/j.ejca.2020.07.018 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.ejca.2020.07.018 |
container_title |
European Journal of Cancer |
container_volume |
138 |
container_start_page |
80 |
op_container_end_page |
88 |
_version_ |
1797585661497180160 |