An in situ study investigating dentine tubule occlusion of dentifrices following acid challenge
Objectives: To investigate the dentine occlusion and acid resistance of dentifrices developed to treat dentine hypersensitivity. Methods: This was a single centre, single blind, randomised, split mouth, four treatments, two period crossover, in situ study in healthy subjects. Subjects wore buccal in...
Published in: | Journal of Dentistry |
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Language: | English |
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2012
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Online Access: | https://kclpure.kcl.ac.uk/portal/en/publications/2c2aff86-c72d-4238-b174-d2105b93b44e https://doi.org/10.1016/j.jdent.2012.03.008 |
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ftkingscollondon:oai:kclpure.kcl.ac.uk:publications/2c2aff86-c72d-4238-b174-d2105b93b44e 2024-09-15T18:01:42+00:00 An in situ study investigating dentine tubule occlusion of dentifrices following acid challenge Olley, Ryan Pilecki, Peter Hughes, Nathan Jeffery, Peter Austin, Rupert S. Moazzez, Rebecca Bartlett, David 2012-07 https://kclpure.kcl.ac.uk/portal/en/publications/2c2aff86-c72d-4238-b174-d2105b93b44e https://doi.org/10.1016/j.jdent.2012.03.008 eng eng https://kclpure.kcl.ac.uk/portal/en/publications/2c2aff86-c72d-4238-b174-d2105b93b44e info:eu-repo/semantics/restrictedAccess Olley , R , Pilecki , P , Hughes , N , Jeffery , P , Austin , R S , Moazzez , R & Bartlett , D 2012 , ' An in situ study investigating dentine tubule occlusion of dentifrices following acid challenge ' , Journal of Dentistry , vol. 40 , no. 7 , pp. 585-593 . https://doi.org/10.1016/j.jdent.2012.03.008 Acetates Adult Arginine Beverages Calcium Carbonate Carbonated Beverages Carbonic Acid Citric Acid Citrus paradisi Citrus sinensis Cross-Over Studies Dentifrices Dentin Dentin Desensitizing Agents Female Fluorides Humans Male Microscopy Electron Scanning Phosphates Single-Blind Method Sodium Fluoride Strontium article 2012 ftkingscollondon https://doi.org/10.1016/j.jdent.2012.03.008 2024-07-22T23:49:20Z Objectives: To investigate the dentine occlusion and acid resistance of dentifrices developed to treat dentine hypersensitivity. Methods: This was a single centre, single blind, randomised, split mouth, four treatments, two period crossover, in situ study in healthy subjects. Subjects wore buccal intra-oral appliances each fitted with four dentine samples over four consecutive days with one study product applied per appliance; 8% strontium acetate in silica base, 1040 ppm sodium fluoride (Sensodyne (R) Rapid Relief), 8% arginine, calcium carbonate, 1450 ppm sodium monofluorophosphate (Colgate Sensitive Pro-Relief (R)), 1450 ppm sodium fluoride (control paste) and water. On days 3 and 4, two agitated grapefruit juice challenges (ex vivo) occurred for 1 min. At the end of each treatment day 1 dentine sample was removed from each appliance for scanning electron microscopy (SEM). The extent of tubule occlusion was measured using an examiner-based visual scoring index (three trained examiners). Results: In total, 28 subjects ((12 males and 16 females with a mean age of 34.7 years (SD 8.41 years)) completed the study. On day 2, both test dentifrices demonstrated significantly better dentine tubule occlusion than water (p < 0.0001) and control paste (8% strontium p = 0.0003 and 8% arginine p = 0.0019). After 3 and 4 days of twice daily brushing with acid challenges on days 3 and 4 the strontium-based dentifrice demonstrated significantly better dentine occlusion than all other treatments (p < 0.0001). Conclusions: Strontium acetate and arginine-based dentifrice result in statistically significant dentine tubular occlusion compared to controls, but the arginine-based dentifrice is more susceptible to acid challenge. Clinical significance: Erosive beverages are an important aetiology in DH by exposing dentine tubules. Their consumption has increased significantly over the past decade in the UK. This 4-day in situ study investigated the properties of commercially available dentifrices designed to occlude dentine ... Article in Journal/Newspaper Carbonic acid King's College, London: Research Portal Journal of Dentistry 40 7 585 593 |
institution |
Open Polar |
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King's College, London: Research Portal |
op_collection_id |
ftkingscollondon |
language |
English |
topic |
Acetates Adult Arginine Beverages Calcium Carbonate Carbonated Beverages Carbonic Acid Citric Acid Citrus paradisi Citrus sinensis Cross-Over Studies Dentifrices Dentin Dentin Desensitizing Agents Female Fluorides Humans Male Microscopy Electron Scanning Phosphates Single-Blind Method Sodium Fluoride Strontium |
spellingShingle |
Acetates Adult Arginine Beverages Calcium Carbonate Carbonated Beverages Carbonic Acid Citric Acid Citrus paradisi Citrus sinensis Cross-Over Studies Dentifrices Dentin Dentin Desensitizing Agents Female Fluorides Humans Male Microscopy Electron Scanning Phosphates Single-Blind Method Sodium Fluoride Strontium Olley, Ryan Pilecki, Peter Hughes, Nathan Jeffery, Peter Austin, Rupert S. Moazzez, Rebecca Bartlett, David An in situ study investigating dentine tubule occlusion of dentifrices following acid challenge |
topic_facet |
Acetates Adult Arginine Beverages Calcium Carbonate Carbonated Beverages Carbonic Acid Citric Acid Citrus paradisi Citrus sinensis Cross-Over Studies Dentifrices Dentin Dentin Desensitizing Agents Female Fluorides Humans Male Microscopy Electron Scanning Phosphates Single-Blind Method Sodium Fluoride Strontium |
description |
Objectives: To investigate the dentine occlusion and acid resistance of dentifrices developed to treat dentine hypersensitivity. Methods: This was a single centre, single blind, randomised, split mouth, four treatments, two period crossover, in situ study in healthy subjects. Subjects wore buccal intra-oral appliances each fitted with four dentine samples over four consecutive days with one study product applied per appliance; 8% strontium acetate in silica base, 1040 ppm sodium fluoride (Sensodyne (R) Rapid Relief), 8% arginine, calcium carbonate, 1450 ppm sodium monofluorophosphate (Colgate Sensitive Pro-Relief (R)), 1450 ppm sodium fluoride (control paste) and water. On days 3 and 4, two agitated grapefruit juice challenges (ex vivo) occurred for 1 min. At the end of each treatment day 1 dentine sample was removed from each appliance for scanning electron microscopy (SEM). The extent of tubule occlusion was measured using an examiner-based visual scoring index (three trained examiners). Results: In total, 28 subjects ((12 males and 16 females with a mean age of 34.7 years (SD 8.41 years)) completed the study. On day 2, both test dentifrices demonstrated significantly better dentine tubule occlusion than water (p < 0.0001) and control paste (8% strontium p = 0.0003 and 8% arginine p = 0.0019). After 3 and 4 days of twice daily brushing with acid challenges on days 3 and 4 the strontium-based dentifrice demonstrated significantly better dentine occlusion than all other treatments (p < 0.0001). Conclusions: Strontium acetate and arginine-based dentifrice result in statistically significant dentine tubular occlusion compared to controls, but the arginine-based dentifrice is more susceptible to acid challenge. Clinical significance: Erosive beverages are an important aetiology in DH by exposing dentine tubules. Their consumption has increased significantly over the past decade in the UK. This 4-day in situ study investigated the properties of commercially available dentifrices designed to occlude dentine ... |
format |
Article in Journal/Newspaper |
author |
Olley, Ryan Pilecki, Peter Hughes, Nathan Jeffery, Peter Austin, Rupert S. Moazzez, Rebecca Bartlett, David |
author_facet |
Olley, Ryan Pilecki, Peter Hughes, Nathan Jeffery, Peter Austin, Rupert S. Moazzez, Rebecca Bartlett, David |
author_sort |
Olley, Ryan |
title |
An in situ study investigating dentine tubule occlusion of dentifrices following acid challenge |
title_short |
An in situ study investigating dentine tubule occlusion of dentifrices following acid challenge |
title_full |
An in situ study investigating dentine tubule occlusion of dentifrices following acid challenge |
title_fullStr |
An in situ study investigating dentine tubule occlusion of dentifrices following acid challenge |
title_full_unstemmed |
An in situ study investigating dentine tubule occlusion of dentifrices following acid challenge |
title_sort |
in situ study investigating dentine tubule occlusion of dentifrices following acid challenge |
publishDate |
2012 |
url |
https://kclpure.kcl.ac.uk/portal/en/publications/2c2aff86-c72d-4238-b174-d2105b93b44e https://doi.org/10.1016/j.jdent.2012.03.008 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
Olley , R , Pilecki , P , Hughes , N , Jeffery , P , Austin , R S , Moazzez , R & Bartlett , D 2012 , ' An in situ study investigating dentine tubule occlusion of dentifrices following acid challenge ' , Journal of Dentistry , vol. 40 , no. 7 , pp. 585-593 . https://doi.org/10.1016/j.jdent.2012.03.008 |
op_relation |
https://kclpure.kcl.ac.uk/portal/en/publications/2c2aff86-c72d-4238-b174-d2105b93b44e |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.jdent.2012.03.008 |
container_title |
Journal of Dentistry |
container_volume |
40 |
container_issue |
7 |
container_start_page |
585 |
op_container_end_page |
593 |
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1810438792313569280 |